Arsenic concentration in topsoil of central Chile is associated with aberrant methylation of P53 gene in human blood cells: a cross-sectional study
| Primer Autor |
Madrid, Eva
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| Co-autores |
Gonzalez-Miranda, Isabel
Munoz, Sergio
Rejas, Carolina
Cardemil, Felipe
Martinez, Felipe
Pablo Cortes, Juan
Berasaluce, Maite
Parraga, Mario
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| Título |
Arsenic concentration in topsoil of central Chile is associated with aberrant methylation of P53 gene in human blood cells: a cross-sectional study
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| Editorial |
SPRINGER HEIDELBERG
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| Revista |
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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| Lenguaje |
en
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| Resumen |
Gene expression can be modified in people who are chronically exposed to high concentrations of heavy metals. The soil surrounding the Ventanas Industrial Complex, located on the coastal zone of Puchuncavi and Quintero townships (Chile), contain heavy metal concentrations (As, Cu, Pb, Zn, among others) that far exceed international standards. The aim of this study was to determine the potential association of the heavy metals in soils, especially arsenic, with the status of methylation of four tumor suppressor genes in permanent residents in those townships. To study the methylation status in genes p53, p16, APC, and RASSF1A, we took blood samples from adults living in areas near the industrial complex for at least 5 years and compared it to blood samples from adults living in areas with normal heavy metal concentrations of soils. Results indicated that inhabitants of an area with high levels of heavy metals in soil have a significantly higher proportion of methylation in the promoter region of the p53 tumor suppressor gene compared with control areas (p-value: 0.0035). This is the first study to consider associations between heavy metal exposure in humans and aberrant DNA methylation in Chile. Our results suggest more research to support consistent decision-making on processes of environmental remediation or prevention of exposure.
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| Tipo de Recurso |
artículo original
|
| doi |
10.1007/s11356-022-19085-2
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| Formato Recurso |
PDF
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| Palabras Claves |
DNA methylation
Epigenetics
Heavy metal
Soil pollution
RASSF1A TUMOR-SUPPRESSOR
COPPER SMELTER
TRACE-ELEMENTS
ENVIRONMENTAL EPIGENETICS
ATMOSPHERIC DEPOSITION
PUCHUNCAVI VALLEY
SPATIAL VARIATION
DNA METHYLATION
HEAVY-METALS
SOILS
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| Ubicación del archivo | |
| Categoría OCDE |
Ciencias Ambientales
|
| Materias |
Metilación del ADN
Epigenética
Metales pesados
Contaminación del suelo
SUPRENSOR DE TUMORES RASSF1A
FUSIÓN DE COBRE
OLIGOELEMENTOS
EPIGENÉTICA AMBIENTAL
DEPOSICIÓN ATMOSFÉRICA
VALLE DE PUCHUNCAVI
VARIACIÓN ESPACIAL
METILACIÓN DEL ADN
METALES PESADOS
SUELOS
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| Título de la cita (Recomendado-único) |
Arsenic concentration in topsoil of central Chile is associated with aberrant methylation of P53 gene in human blood cells: a cross-sectional study
|
| Página de inicio (Recomendado-único) |
48250
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| Página final (Recomendado-único) |
48259
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| Identificador del recurso (Mandatado-único) |
artículo original
|
| Versión del recurso (Recomendado-único) |
version publicada
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| Condición de la licencia (Recomendado-repetible) |
0
|
| Derechos de acceso |
restringido
|
| Access Rights |
restringido
|
| Id de Web of Science |
WOS:000758996700018
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