Varicocele at High Altitude, Venous Outflow Restriction by Hypobaric Hypoxia

Primer Autor
Behn, Claus
Co-autores
Alcantara-Zapata, Diana
Nazzal, Carolina
Munoz, Sergio
De Gregorio, Nicole
Marchetti, Nella
Título
Varicocele at High Altitude, Venous Outflow Restriction by Hypobaric Hypoxia
Editorial
BENTHAM SCIENCE PUBL LTD
Revista
CURRENT VASCULAR PHARMACOLOGY
Lenguaje
en
Resumen
"Background: Testicular aches have been reported to occur on exposure to high altitude (HA). As a painful expression of venous congestion at the pampiniform plexus, varicocele (VC) might be a consequence of cardiovascular adjustments at HA. Chile's National Social Security Regulatory Body (SUSESO) emphasized evaluating this condition in the running follow-up study ""Health effects of exposure to chronic intermittent hypoxia in Chilean mining workers."" Objectives: This study aimed at investigating the prevalence of VC in a population usually shifting between sea level and HA, thereby intermittently being exposed to hypobaric hypoxia. Methodology: Miners (n=492) agreed to be examined at their working place by a physician, in the context of a general health survey, for the presence of palpable VC, either visible or not. Among them was a group exposed to low altitude (LA) <2,400 m, n=123, another one exposed to moderate high altitude (MHA) working 3,050 m, n=70, and a third one exposed to very high altitude (VHA) >3,900 m, n=165. The Chi(2) test and Kruskal-Wallis test were used for the descriptive analyses, and logistic regression was applied to evaluate the association of VC with exposure to HA. The Ethics Committee for Research in Human Beings, Faculty of Medicine, University of Chile, approved this project. Results: VC prevalence (grades 2 and 3) was found to be 10% at LA, 4.1% at MHA, and 16.7% at VHA (p <= 0.05). Hemoglobin oxygen saturation (SaO(2)) was lower, and hemoglobin concentrations were higher in workers with high-grade VC at VHA compared to LA and MHA (Wilcoxon tests, p<0.001). Odds ratios (OR) for the association of VC with HA were 3.7 (95%CI: 1.26 to 12.3) and 4.06 (95%CI: 1.73 to 11.2) for MHA and VHA, respectively Conclusion: Association of VC with HA, a clinically relevant finding, may be related to blood volume centralization mediated by hypobaric hypoxia."
Tipo de Recurso
artículo original
doi
10.2174/1570161120666220510120831
Formato Recurso
PDF
Palabras Claves
Varicocele
high altitude
hypobaric
hypoxia
venous
outflow
varicocele
CEREBRAL-BLOOD-FLOW
ACUTE MOUNTAIN-SICKNESS
SYMPATHETIC ACTIVATION
TIGHT NECKTIE
HEAD-INJURY
EXPOSURE
EXERCISE
HYPERVENTILATION
ENDOTHELIN-1
PRESSURE
Ubicación del archivo
http://dx.doi.org/10.2174/1570161120666220510120831
Categoría OCDE
Farmacología y Farmacia
Enfermedad vascular periférica
Materias
Varicocele
gran altitud
hipobárico
hipoxia
venoso
flujo de salida
varicocele
FLUJO DE SANGRE CEREBRAL
MAL DE MONTAÑA AGUDO
ACTIVACIÓN SIMPÁTICA
COBATA APRETADA
LESIÓN EN LA CABEZA
EXPOSICIÓN
EJERCICIO
HIPERVENTILACIÓN
ENDOTELINA-1
PRESIÓN
Disciplinas de la OCDE
Andrología
Fisiología
Urología y Nefrología
Título de la cita (Recomendado-único)
Varicocele at High Altitude, Venous Outflow Restriction by Hypobaric Hypoxia
Página de inicio (Recomendado-único)
303
Página final (Recomendado-único)
309
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
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Id de Web of Science
WOS:000864633000009
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