A bioinformatics analysis of the CatSper channel in the class Actinopterygii

Primer Autor
Farias, Jorge G.
Co-autores
Beltran, Jorge F.
Parraguez Contreras, Fernanda
Norambuena, Juan-Alejandro
Herrera Belen, Lisandra
Risopatron, Jennie
Valdebenito, Ivan
Figueroa, Elias
Título
A bioinformatics analysis of the CatSper channel in the class Actinopterygii
Editorial
ELSEVIER SCIENCE INC
Revista
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
Lenguaje
en
Resumen
The regulation of sperm motility is controlled by several variables, including mainly ion concentrations. In fish, Ca2+ concentrations play an important role in the regulation of sperm motility, and several reports highlight the importance of certain Ca2+ channels in the regulation of this cell function. CatSper is a calcium channel scarcely studied in fish. In the species Salmo salar, it has been shown that it is key in the regulation of sperm motility. Taking into account the relevance of this channel in sperm activation in fish, in this study we evaluated the presence and probable functionality of this channel in the class Actinopterygii. For this purpose, a rational bioinformatic analysis was carried out, which had been previously validated using in vitro techniques by our group. The bioinformatic analysis of the present work revealed that the functionality of CatSper of the species of the class Actinopterygii could be exclusive to freshwater and anadromous fish species. The results of this study showed that only some anadromous and freshwater fish species contain 11 subunits of the CatSper channel, which are enough to trigger sperm motility. Consequently, this study provides new data for a better under-standing of the sperm activation mechanism in fish.
Tipo de Recurso
artículo original
Description
This work was supported by the projects FONDECYT No. 1180387, UFRO DI21-0111, and UFRO GAP DI5/2021.
Este trabajo contó con el apoyo de los proyectos FONDECYT N° 1180387, UFRO DI21-0111 y UFRO GAP DI5/2021.
doi
10.1016/j.cbpa.2022.111181
Formato Recurso
PDF
Palabras Claves
Fish
CatSper
Bioinformatics
Sperm
Actinopterygii
Ubicación del archivo
http://dx.doi.org/10.1016/j.cbpa.2022.111181
Categoría OCDE
Bioquímica y Biología Molecular
Fisiología
Zoología
Materias
Pescado
CatSper
Bioinformática
Esperma
Actinopterygii
Disciplinas de la OCDE
Biología Molecular
Biología Reproductiva
Zoología, Ornitología, Entomología y Comportamiento Biológico
Título de la cita (Recomendado-único)
A bioinformatics analysis of the CatSper channel in the class Actinopterygii
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
Derechos de acceso
metadata
Access Rights
metadata
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID-FONDECYT 1180387
UFRO DI21-0111
UFRO GAP DI5/2021.
ANID FONDECYT 1180387
Id de Web of Science
WOS:000793732700009
Colecciones
Colección Publicaciones Científicas
Colección ANID
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