Myricetin: targeting signaling networks in cancer and its implication in chemotherapy

Primer Autor
Iqbal, Muhammad Javed
Co-autores
Javed, Zeeshan
Khan, Khushbukhat
Herrera-Bravo, Jesus
Naeem, Sajid
Raza, Qamar
Sadia, Haleema
Raza, Shahid
Bhinder, Munir
Calina, Daniela
Sharifi-Rad, Javad
Cho, William C.
Título
Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
Editorial
BMC
Revista
CANCER CELL INTERNATIONAL
Lenguaje
en
Resumen
The gaps between the complex nature of cancer and therapeutics have been narrowed down due to extensive research in molecular oncology. Despite gathering massive insight into the mysteries of tumor heterogeneity and the molecular framework of tumor cells, therapy resistance and adverse side effects of current therapeutic remain the major challenge. This has shifted the attention towards therapeutics with less toxicity and high efficacy. Myricetin a natural flavonoid has been under the spotlight for its anti-cancer, anti-oxidant, and anti-inflammatory properties. The cutting-edge molecular techniques have shed light on the interplay between myricetin and dysregulated signaling cascades in cancer progression, invasion, and metastasis. However, there are limited data available regarding the nano-delivery platforms composed of myricetin in cancer. In this review, we have provided a comprehensive detail of myricetin-mediated regulation of different cellular pathways, its implications in cancer prevention, preclinical and clinical trials, and its current available nano-formulations for the treatment of various cancers.
Tipo de Recurso
artículo de revisión
doi
10.1186/s12935-022-02663-2
Formato Recurso
PDF
Palabras Claves
Myricetin
Cancer
Signaling networks
Apoptosis
Cell cycle
Nano-delivery
DIETARY FLAVONOID INTAKE
IN-VITRO
CELL-DEATH
INHIBITS PROLIFERATION
PROSTATE-CANCER
LUNG-CANCER
HEPG2 CELLS
APOPTOSIS
EXPRESSION
PATHWAY
Ubicación del archivo
http://dx.doi.org/10.1186/s12935-022-02663-2
Categoría OCDE
Oncología
Materias
Miricetina
Cáncer
Redes de señalización
Apoptosis
Ciclo celular
Nanoentrega
INGESTA DE FLAVONOIDES DIETÉTICOS
IN VITRO
MUERTE CELULAR
INHIBE LA PROLIFERACIÓN
CÁNCER DE PRÓSTATA
CÁNCER DE PULMÓN
CÉLULAS HEPG2
APOPTOSIS
EXPRESIÓN
CAMINO
Disciplinas de la OCDE
Oncología
Biología Molecular
Farmacología y Farmacia
Título de la cita (Recomendado-único)
Myricetin: targeting signaling networks in cancer and its implication in chemotherapy
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000832677200002
Colecciones
Colección Publicaciones Científicas
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