Which physical therapy intervention is most effective in reducing secondary lymphoedema associated with breast cancer? Protocol for a systematic review and network meta-analysis

Primer Autor
Zaror, Carlos
Co-autores
Alberto Aguilera-Eguia, Raul
Seron, Pamela
Gutierrez-Arias, Ruvistay
Título
Which physical therapy intervention is most effective in reducing secondary lymphoedema associated with breast cancer? Protocol for a systematic review and network meta-analysis
Editorial
BMJ PUBLISHING GROUP
Revista
BMJ OPEN
Lenguaje
en
Resumen
Introduction Lymphoedema associated with breast cancer is caused by an interruption of the lymphatic system, together with factors such as total mastectomy, axillary dissection, positive lymph nodes, radiotherapy, use of taxanes and obesity. Physiotherapy treatment consists of complex decongestive therapy, manual lymphatic drainage and exercises, among other interventions. Currently, there are several systematic review and randomised controlled trials that evaluate the efficacy of these interventions. However, at present, there are no studies that compare the effectiveness of all these physical therapy interventions. The purpose of this study is to determine which physical therapy treatment is most effective in reducing breast cancer-related lymphoedema, improving quality of life and reducing pain. Methods and analysis MEDLINE, PEDro, CINAHL, EMBASE, LILACS and Cochrane Central Register of Controlled Trials will be searched for reports of randomised controlled trials published from database inception to June 2022. We will only include studies that are written in English, Spanish and Portuguese. We will also search grey literature, preprint servers and clinical trial registries. The primary outcomes are reduction of secondary lymphoedema associated with breast cancer, improvements in quality of life and pain reduction. The risk of bias of individual studies will be evaluated using the Cochrane Risk of Bias 2.0 Tool. A network meta-analysis will be performed using a random-effects model. First, pairs will be directly meta-analysed and indirect comparisons will be made between the different physical therapy treatments. The GRADE system will be used to assess the overall quality of the body of evidence associated with the main results. Ethics and dissemination This protocol does not require approval from an ethics committee. The results will be disseminated via peer-reviewed publications. PROSPERO registration number CDR42022323541.
Tipo de Recurso
artículo de revisión
doi
10.1136/bmjopen-2022-065045
Formato Recurso
PDF
Palabras Claves
Breast tumours
REHABILITATION MEDICINE
PUBLIC HEALTH
ONCOLOGY
LEVEL LASER THERAPY
RESISTANCE EXERCISE
CONSISTENCY
MANAGEMENT
STATEMENT
WOMEN
PAIN
Ubicación del archivo
http://dx.doi.org/10.1136/bmjopen-2022-065045
Categoría OCDE
Medicina general e interna
Materias
Tumores de mama
MEDICINA DE REHABILITACIÓN
SALUD PÚBLICA
ONCOLOGÍA
TERAPIA LÁSER DE NIVEL
EJERCICIO DE RESISTENCIA
CONSISTENCIA
MANEJO
DECLARACIÓN
MUJERES
DOLOR
Disciplinas de la OCDE
Oncología
Fisiología
Otros Temas de Medicina Clínica
Título de la cita (Recomendado-único)
Which physical therapy intervention is most effective in reducing secondary lymphoedema associated with breast cancer? Protocol for a systematic review and network meta-analysis
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY-NC 4.0
Condición de la licencia (Recomendado-repetible)
CC BY-NC 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000863032400035
Colecciones
Colección Publicaciones Científicas
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