Cisplatin Resistance: Genetic and Epigenetic Factors Involved
Primer Autor |
Salazar, Luis A.
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Co-autores |
Lugones, Yuliannis
Loren, Pia
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Título |
Cisplatin Resistance: Genetic and Epigenetic Factors Involved
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Editorial |
MDPI
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Revista |
BIOMOLECULES
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Lenguaje |
en
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Resumen |
Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, alternative splicing, epigenetic-driven expression changes, and even post-translational modifications of proteins. However, the molecular mechanisms by which CDDP resistance develops are not clear but are believed to be multi-factorial. This article highlights a description of cisplatin, which includes action mechanism, resistance, and epigenetic factors involved in cisplatin resistance.
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Tipo de Recurso |
artículo de revisión
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Description |
This research was funded by ANID-FAPESP (Grant No. 19/13250-1), FONDECYT Postdoctoral (Grant No. 3220404) awarded to P.L., and the ANID Scholarship to Y.L. (No. 21210202).
Esta investigación fue financiada por ANID-FAPESP (Beca N° 19/13250-1), FONDECYT Postdoctoral (Beca N° 3220404) otorgada a P.L., y la Beca ANID a Y.L. (Nº 21210202).
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doi |
10.3390/biom12101365
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Formato Recurso |
PDF
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Palabras Claves |
cancer
cisplatin
drug resistance
epigenetics
SQUAMOUS-CELL CARCINOMA
NONCODING RNA HOTTIP
BLADDER-CANCER CELLS
NF-KAPPA-B
MOLECULAR-MECHANISMS
INDUCED APOPTOSIS
INCREASES CHEMORESISTANCE
PLATINUM RESISTANCE
DNA METHYLATION
OVARIAN-CANCER
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Ubicación del archivo | |
Categoría OCDE |
Bioquímica y biología molecular
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Materias |
cáncer
cisplatino
resistencia a los medicamentos
epigenética
CARCINOMA DE CÉLULAS ESCAMOSAS
ARN NO CODIFICADOR HOTTIP
CÉLULAS CÁNCER DE VEJIGA
NF-KAPPA-B
MECANISMOS-MOLECULARES
APOPTOSIS INDUCIDA
AUMENTA LA QUIMORESISTENCIA
RESISTENCIA AL PLATINO
METILACIÓN DEL ADN
CÁNCER DE OVARIO
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Título de la cita (Recomendado-único) |
Cisplatin Resistance: Genetic and Epigenetic Factors Involved
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Identificador del recurso (Mandatado-único) |
artículo de revisión
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Versión del recurso (Recomendado-único) |
version publicada
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License |
CC BY 4.0
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Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
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Derechos de acceso |
acceso abierto
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Access Rights |
acceso abierto
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Referencia del Financiador (Mandatado si es aplicable-repetible) |
FAPESP 19/13250-1
ANID-FONDECYT 3220404
ANID 21210202
ANID FONDECYT 3220404
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Id de Web of Science |
WOS:000872319800001
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