Repositorio UFRO · Omeka S

MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin-Induced Nephrotoxicity: Potential Use of Natural Products against DDP-Induced Apoptosis

Primer Autor	Salazar, Luis A.
Co-autores	Loren, Pia Lugones, Yuliannis Saavedra, Nicolas Saavedra, Kathleen Paez, Isis Rodriguez, Nelia Moriel, Patricia
Título	MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin-Induced Nephrotoxicity: Potential Use of Natural Products against DDP-Induced Apoptosis
Editorial	MDPI
Revista	BIOMOLECULES
Lenguaje	en
Resumen	Cisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in DDP-induced nephrotoxicity. Noncoding RNAs (ncRNAs), a class of epigenetic processes, are molecules that regulate gene expression under physiological and pathological conditions. MicroRNAs (miRNAs) are the most characterized class of ncRNAs and are engaged in many cellular processes. In this review, we describe how different miRNAs regulate some pathways leading to cell death by apoptosis, specifically the intrinsic apoptosis pathway. Accordingly, many classes of natural products have been tested for their ability to prevent DDP-induced apoptosis. The study of epigenetic regulation for underlying cell death is still being studied, which will allow new strategies for the diagnosis and therapy of this unwanted disease, which is presented as a side effect of antineoplastic treatment.
Tipo de Recurso	artículo de revisión
Description	This research was funded by ANID-FAPESP (grant no. 19/13250-1), FONDECYT (grant no. 1171765) and FONDECYT postdoctoral grant no. 3220404 awarded to P.L. Esta investigación fue financiada por ANID-FAPESP (beca no. 19/13250-1), FONDECYT (beca no. 1171765) y beca postdoctoral FONDECYT no. 3220404 otorgada a P.L.
doi	10.3390/biom12091206
Formato Recurso	PDF
Palabras Claves	apoptosis miRNAs noncoding RNAs AKI cell death ACUTE KIDNEY INJURY ACUTE RENAL INJURY OXIDATIVE STRESS OXIDATIVE/NITROSATIVE STRESS CANCER STATISTICS CELL APOPTOSIS ENDONUCLEASE-G CYTOCHROME-C DNA-DAMAGE INFLAMMATION
Ubicación del archivo	http://dx.doi.org/10.3390/biom12091206
Categoría OCDE	Bioquímica y biología molecular
Materias	apoptosis miARN ARN no codificantes AKI muerte celular LESIÓN RENAL AGUDA ESTRÉS OXIDATIVO ESTRÉS OXIDATIVO/NITROSATIVO ESTADÍSTICAS DEL CÁNCER APOPTOSIS CELULAR ENDONUCLEASE-G CITOCROMO-C DAÑO AL ADN INFLAMACIÓN
Disciplinas de la OCDE	Farmacología y Farmacia Toxicología Oncología
Título de la cita (Recomendado-único)	MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin-Induced Nephrotoxicity: Potential Use of Natural Products against DDP-Induced Apoptosis
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	version publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)	FAPESP 19/13250-1 ANID-FONDECYT 3220404 ANID-FONDECYT 1171765 ANID FONDECYT 3220404 ANID FONDECYT 1171765
Id de Web of Science	WOS:000856294700001