MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin-Induced Nephrotoxicity: Potential Use of Natural Products against DDP-Induced Apoptosis

Primer Autor
Salazar, Luis A.
Co-autores
Loren, Pia
Lugones, Yuliannis
Saavedra, Nicolas
Saavedra, Kathleen
Paez, Isis
Rodriguez, Nelia
Moriel, Patricia
Título
MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin-Induced Nephrotoxicity: Potential Use of Natural Products against DDP-Induced Apoptosis
Editorial
MDPI
Revista
BIOMOLECULES
Lenguaje
en
Resumen
Cisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in DDP-induced nephrotoxicity. Noncoding RNAs (ncRNAs), a class of epigenetic processes, are molecules that regulate gene expression under physiological and pathological conditions. MicroRNAs (miRNAs) are the most characterized class of ncRNAs and are engaged in many cellular processes. In this review, we describe how different miRNAs regulate some pathways leading to cell death by apoptosis, specifically the intrinsic apoptosis pathway. Accordingly, many classes of natural products have been tested for their ability to prevent DDP-induced apoptosis. The study of epigenetic regulation for underlying cell death is still being studied, which will allow new strategies for the diagnosis and therapy of this unwanted disease, which is presented as a side effect of antineoplastic treatment.
Tipo de Recurso
artículo de revisión
Description
This research was funded by ANID-FAPESP (grant no. 19/13250-1), FONDECYT (grant no. 1171765) and FONDECYT postdoctoral grant no. 3220404 awarded to P.L.
Esta investigación fue financiada por ANID-FAPESP (beca no. 19/13250-1), FONDECYT (beca no. 1171765) y beca postdoctoral FONDECYT no. 3220404 otorgada a P.L.
doi
10.3390/biom12091206
Formato Recurso
PDF
Palabras Claves
apoptosis
miRNAs
noncoding RNAs
AKI
cell death
ACUTE KIDNEY INJURY
ACUTE RENAL INJURY
OXIDATIVE STRESS
OXIDATIVE/NITROSATIVE STRESS
CANCER STATISTICS
CELL APOPTOSIS
ENDONUCLEASE-G
CYTOCHROME-C
DNA-DAMAGE
INFLAMMATION
Ubicación del archivo
http://dx.doi.org/10.3390/biom12091206
Categoría OCDE
Bioquímica y biología molecular
Materias
apoptosis
miARN
ARN no codificantes
AKI
muerte celular
LESIÓN RENAL AGUDA
ESTRÉS OXIDATIVO
ESTRÉS OXIDATIVO/NITROSATIVO
ESTADÍSTICAS DEL CÁNCER
APOPTOSIS CELULAR
ENDONUCLEASE-G
CITOCROMO-C
DAÑO AL ADN
INFLAMACIÓN
Título de la cita (Recomendado-único)
MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin-Induced Nephrotoxicity: Potential Use of Natural Products against DDP-Induced Apoptosis
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Referencia del Financiador (Mandatado si es aplicable-repetible)
FAPESP 19/13250-1
ANID-FONDECYT 3220404
ANID-FONDECYT 1171765
ANID FONDECYT 3220404
ANID FONDECYT 1171765
Id de Web of Science
WOS:000856294700001
Colecciones
Colección Publicaciones Científicas
Colección ANID
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