Repositorio
Institucional

Rivera-Meza, Mario

Galvez, Gabriel

Gonzalez-Gutierrez, Juan Pablo

Hodar-Salazar, Martin

Sotomayor-Zarate, Ramon

Quintanilla, Maria Elena

Quilaqueo, Maria Elena

Iturriaga-Vasquez, Patricio

UFR2709, an Antagonist of Nicotinic Acetylcholine Receptors, Delays the Acquisition and Reduces Long-Term Ethanol Intake in Alcohol-Preferring UChB Bibulous Rats

MDPI

BIOMEDICINES

en

Alcoholism is a worldwide public health problem with high economic cost and which affects health and social behavior. It is estimated that alcoholism kills 3 million people globally, while in Chile it is responsible for around 9 thousand deaths per year. Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels expressed in the central nervous system, and they were suggested to modulate the ethanol mechanism involved in abuse and dependence. Previous work demonstrated a short-term treatment with UFR2709, a nAChRs antagonist, which reduced ethanol intake using a two-bottle free-choice paradigm in University of Chile bibulous (UChB) rats. Here, we present evidence of the UFR2709 efficacy in reducing the acquisition and long-term ethanol consumption. Our results show that UFR2709 (2.5 mg/kg i.p.) reduces the seek behavior and ethanol intake, even when the drug administration was stopped, and induced a reduction in the overall ethanol intake by around 55%. Using naive UChB bibulous rats, we demonstrate that UFR2709 could delay and reduce the genetically adaptive impulse to seek and drink ethanol and prevent its excessive intake.

artículo original

This work was supported by the National Agency of Research and Development (ANIDChile) through FONDECYT Grants N ffi116-0398 and 120-0474 to R.S.-Z., 120-1577 to M.R.-M., 115-0615 to P.I.-V. and 322-0275 to J.P.G.-G. Partial support was received from DIUV-CI Grant Nffi 01/2006 (to R.S.-Z.). ANID [ACT210012] M.R.-M. M.H.-S. is a fellow of the CONICYT National Ph.D. Scholar Fellowship.

Este trabajo contó con el apoyo de la Agencia Nacional de Investigación y Desarrollo (ANIDChile) a través de los Becas FONDECYT N° ffi116-0398 y 120-0474 a R.S.-Z., 120-1577 a M.R.-M., 115-0615 a P.I.-V. y 322-0275 a J.P.G.-G. Se recibió apoyo parcial de la subvención DIUV-CI Nffi 01/2006 (a R.S.-Z.). ANID [ACT210012] M.R.-M. M.H.-S. Es becario del Doctorado Nacional de CONICYT. Beca académica.

10.3390/biomedicines10071482

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UFR2709

voluntary ethanol intake

UChB rats

nicotinic antagonist

PARTIAL AGONIST VARENICLINE

ACCUMBAL DOPAMINE OVERFLOW

VENTRAL TEGMENTAL AREA

CONSUMPTION

HIPPOCAMPAL

SENSITIVITY

DEPENDENCE

CYTISINE

SMOKING

DRUGS

Bioquímica y Biología Molecular

Medicina

Investigación y Experimental

Farmacología y farmacia

UFR2709

ingesta voluntaria de etanol

ratas UChB

antagonista nicotínico

AGONISTA PARCIAL VARENICLINA

DESBORDAMIENTO DE DOPAMINA ACUMBARAL

ÁREA TEGMENTAL VENTRAL

CONSUMO

HIPOCAMPAL

SENSIBILIDAD

DEPENDENCIA

CITISINA

FUMAR

DROGAS

UFR2709, an Antagonist of Nicotinic Acetylcholine Receptors, Delays the Acquisition and Reduces Long-Term Ethanol Intake in Alcohol-Preferring UChB Bibulous Rats

artículo original

version publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

ANID-FONDECYT 116-0398

ANID-FONDECYT 120-0474

ANID-FONDECYT 120-1577

ANID-FONDECYT 115-0615

ANID-FONDECYT 322-0275

UV DIUV-CI 01/2006

ANID ACT210012

ANID FONDECYT 116-0398

ANID FONDECYT 120-0474

ANID FONDECYT 120-1577

ANID FONDECYT 115-0615

ANID FONDECYT 322-0275

WOS:000833892500001