Repositorio UFRO · Omeka S

Recent advances in the therapeutic potential of emodin for human health

Primer Autor	Martorell, Miquel
Co-autores	Sharifi-Rad, Javad Herrera-Bravo, Jesus Kamiloglu, Senem Petroni, Katia Mishra, Abhay Prakash Monserrat-Mesquida, Margalida Sureda, Antoni Aidarbekovna, Dossymbetova Symbat Yessimsiitova, Zura Ydyrys, Alibek Hano, Christophe Calina, Daniela Cho, William C.
Título	Recent advances in the therapeutic potential of emodin for human health
Editorial	ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Revista	BIOMEDICINE & PHARMACOTHERAPY
Lenguaje	en
Resumen	Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a bioactive compound, a natural anthraquinone aglycone, present mainly in herbaceous species of the families Fabaceae, Polygonaceae and Rhamnaceae, with a physio-logical role in protection against abiotic stress in vegetative tissues. Emodin is mainly used in traditional Chinese medicine to treat sore throats, carbuncles, sores, blood stasis, and damp-heat jaundice. Pharmacological research in the last decade has revealed other potential therapeutic applications such as anticancer, neuroprotective, antidiabetic, antioxidant and anti-inflammatory.The present study aimed to summarize recent studies on bioavailability, preclinical pharmacological effects with evidence of molecular mechanisms, clinical trials and clinical pitfalls, respectively the therapeutic limita-tions of emodin. For this purpose, extensive searches were performed using the PubMed/Medline, Scopus, Google scholar, TRIP database, Springer link, Wiley and SciFinder databases as a search engines. The in vitro and in vivo studies included in this updated review highlighted the signaling pathways and molecular mechanisms of emodin. Because its bioavailability is low, there are limitations in clinical therapeutic use. In conclusion, for an increase in pharmacotherapeutic efficacy, future studies with carrier molecules to the target, thus opening up new therapeutic perspectives.
Tipo de Recurso	artículo original
doi	10.1016/j.biopha.2022.113555
Formato Recurso	PDF
Palabras Claves	Emodin Pharmacological properties Molecular mechanisms Signaling pathways Clinical trials POLYGONI MULTIFLORI RADIX SEVERE ACUTE-PANCREATITIS OXIDATIVE STRESS ALOE-EMODIN IN-VITRO UDP-GLUCURONOSYLTRANSFERASES ANTHRAQUINONES EMODIN TISSUE DISTRIBUTION DOWN-REGULATION CANCER CELLS
Ubicación del archivo	http://dx.doi.org/10.1016/j.biopha.2022.113555
Categoría OCDE	Medicina Investigación y Experimental Farmacología y farmacia
Materias	Emodina Propiedades farmacológicas Mecanismos moleculares Vías de señalización Ensayos clínicos POLYGONI MULTIFLORI RADIX PANCREATITIS AGUDA SEVERA ESTRÉS OXIDATIVO ALOE-EMODIN IN VITRO UDP-GLUCURONOSILTRANSFERAS ANTRAQUINONAS EMODIN DISTRIBUCIÓN DE TEJIDO REGULACIÓN DESCENDENTE CÉLULAS CÁNCER
Disciplinas de la OCDE	Farmacología y Farmacia Química Orgánica Otros Temas de Medicina Básica
Versión del recurso (Recomendado-único)	version publicada
Tipo de ruta	dorada verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Id de Web of Science	WOS:000861060200012
Título de la cita (Recomendado-único)	Recent advances in the therapeutic potential of emodin for human health
Identificador del recurso (Mandatado-único)	artículo original
License	CC BY-NC-ND 4.0
Condición de la licencia (Recomendado-repetible)	CC BY-NC-ND 4.0