Recent advances in the therapeutic potential of emodin for human health

Primer Autor
Martorell, Miquel
Co-autores
Sharifi-Rad, Javad
Herrera-Bravo, Jesus
Kamiloglu, Senem
Petroni, Katia
Mishra, Abhay Prakash
Monserrat-Mesquida, Margalida
Sureda, Antoni
Aidarbekovna, Dossymbetova Symbat
Yessimsiitova, Zura
Ydyrys, Alibek
Hano, Christophe
Calina, Daniela
Cho, William C.
Título
Recent advances in the therapeutic potential of emodin for human health
Editorial
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Revista
BIOMEDICINE & PHARMACOTHERAPY
Lenguaje
en
Resumen
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a bioactive compound, a natural anthraquinone aglycone, present mainly in herbaceous species of the families Fabaceae, Polygonaceae and Rhamnaceae, with a physio-logical role in protection against abiotic stress in vegetative tissues. Emodin is mainly used in traditional Chinese medicine to treat sore throats, carbuncles, sores, blood stasis, and damp-heat jaundice. Pharmacological research in the last decade has revealed other potential therapeutic applications such as anticancer, neuroprotective, antidiabetic, antioxidant and anti-inflammatory.The present study aimed to summarize recent studies on bioavailability, preclinical pharmacological effects with evidence of molecular mechanisms, clinical trials and clinical pitfalls, respectively the therapeutic limita-tions of emodin. For this purpose, extensive searches were performed using the PubMed/Medline, Scopus, Google scholar, TRIP database, Springer link, Wiley and SciFinder databases as a search engines. The in vitro and in vivo studies included in this updated review highlighted the signaling pathways and molecular mechanisms of emodin. Because its bioavailability is low, there are limitations in clinical therapeutic use. In conclusion, for an increase in pharmacotherapeutic efficacy, future studies with carrier molecules to the target, thus opening up new therapeutic perspectives.
Tipo de Recurso
artículo original
doi
10.1016/j.biopha.2022.113555
Formato Recurso
PDF
Palabras Claves
Emodin
Pharmacological properties
Molecular mechanisms
Signaling pathways
Clinical trials
POLYGONI MULTIFLORI RADIX
SEVERE ACUTE-PANCREATITIS
OXIDATIVE STRESS
ALOE-EMODIN
IN-VITRO
UDP-GLUCURONOSYLTRANSFERASES
ANTHRAQUINONES EMODIN
TISSUE DISTRIBUTION
DOWN-REGULATION
CANCER CELLS
Ubicación del archivo
http://dx.doi.org/10.1016/j.biopha.2022.113555
Categoría OCDE
Medicina
Investigación y Experimental
Farmacología y farmacia
Materias
Emodina
Propiedades farmacológicas
Mecanismos moleculares
Vías de señalización
Ensayos clínicos
POLYGONI MULTIFLORI RADIX
PANCREATITIS AGUDA SEVERA
ESTRÉS OXIDATIVO
ALOE-EMODIN
IN VITRO
UDP-GLUCURONOSILTRANSFERAS
ANTRAQUINONAS EMODIN
DISTRIBUCIÓN DE TEJIDO
REGULACIÓN DESCENDENTE
CÉLULAS CÁNCER
Disciplinas de la OCDE
Farmacología y Farmacia
Química Orgánica
Otros Temas de Medicina Básica
Título de la cita (Recomendado-único)
Recent advances in the therapeutic potential of emodin for human health
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
version publicada
License
CC BY-NC-ND 4.0
Condición de la licencia (Recomendado-repetible)
CC BY-NC-ND 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000861060200012
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