Repositorio
Institucional

Dias, Fernando Jose

Lezcano, Maria Florencia

Alvarez, Giannina

Chuhuaicura, Priscila

Godoy, Karina

Alarcon, Josefa

Acevedo, Francisca

Gareis, Ivan

Polyhydroxybutyrate (PHB) Scaffolds for Peripheral Nerve Regeneration: A Systematic Review of Animal Models

MDPI

BIOLOGY-BASEL

en

"Simple Summary Currently, polymeric biomaterials are the choice for the design of scaffolds for the regeneration of peripheral nerves. Polyhydroxybutyrate (PHB) is a polymer belonging to the class of polyesters that are produced naturally in nature by microorganisms. To gain a better understanding of the efficacy of therapeutic approaches involving PHB scaffolds for peripheral nerve regeneration, we conducted a systematic review of the literature with the aim of discussing the current knowledge of PHB scaffolds applied to nerve regeneration. The use of PHB as a biomaterial to prepare tubular scaffolds for nerve regeneration was shown to be promising. The incorporation of additives appears to be a trend that improves nerve regeneration. In the last two decades, artificial scaffolds for nerve regeneration have been produced using a variety of polymers. Polyhydroxybutyrate (PHB) is a natural polyester that can be easily processed and offer several advantages, hence, the purpose of this review is to provide a better understanding of the efficacy of therapeutic approaches involving PHB scaffolds in promoting peripheral nerve regeneration following nerve dissection in animal models. A systematic literature review was performed following the ""Preferred Reporting Items for Systematic Reviews and Meta-Analyses"" (PRISMA) criteria. The revised databases were: Pub-Med/MEDLINE, Web of Science, Science Direct, EMBASE, and SCOPUS. Sixteen studies were included in this review. Different animal models and nerves were studied. Extension of nerve gaps reconnected by PHB scaffolds and the time periods of analysis were varied. The additives included in the scaffolds, if any, were growth factors, neurotrophins, other biopolymers, and neural progenitor cells. The analysis of the quality of the studies revealed good quality in general, with some aspects that could be improved. The analysis of the risk of bias revealed several weaknesses in all studies. The use of PHB as a biomaterial to prepare tubular scaffolds for nerve regeneration was shown to be promising. The incorporation of additives appears to be a trend that improves nerve regeneration. One of the main weaknesses of the reviewed articles was the lack of standardized experimentation on animals. It is recommended to follow the currently available guidelines to improve the design, avoid the risk of bias, maximize the quality of studies, and enhance translationality."

artículo de revisión

ANID Agencia Nacional de Investigacion y Desarrollo de Chile/Fondo Nacional de Desarrollo Cientifico y Tecnologico-Grant Number: FONDECYT 11190300.

10.3390/biology11050706

PDF

neural repair

biomaterial

PHA-polyhydroxyalkanoate

peripheral nervous system-PNS

GAP REPAIR

CONDUIT

CELLS

FABRICATION

GROWTH

Biología

reparación neuronal

biomaterial

PHA-polihidroxialcanoato

sistema nervioso periférico-SNP

REPARACIÓN DE GAP

CONDUCTO

CÉLULAS

FABRICACIÓN

CRECIMIENTO

Biomateriales (Relacionados con implantes médicos, dispositivos y Sensores)

Ingeniería Médica

Neurociencias

Polyhydroxybutyrate (PHB) Scaffolds for Peripheral Nerve Regeneration: A Systematic Review of Animal Models

artículo de revisión

version publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

ANID-FONDECYT 11190300

ANID FONDECYT 11190300

WOS:000801501900001