Repositorio
Institucional

Sacco, Roberto

Olate, Sergio

Calasans-Maia, Monica Diuana

Sacco, Nicola

Acocella, Alessandro

Mourao, Carlos Fernando De Almeida Barros

Moraschini, Vittorio

Akintola, Oladapo

Guerra, Raphael Capelli

Yates, Julian

A Comprehensive Quality Meta-Review of Genetic and Pharmacogenomic Aspects of Medication-Related Osteonecrosis of The Jaw (MRONJ)

MDPI

APPLIED SCIENCES-BASEL

en

Background: Antiresorptive and antiangiogenic medications can cause a serious adverse effect known as medication-related osteonecrosis of the jaw (MRONJ). In recent years, a new trend of research has emerged emphasizing the potential relation of MRONJ and genetic predisposition. Current evidence-based science of this adverse reaction is associated with poorly performed studies. Additionally, MRONJ research has recently observed a new trend of studies orientated towards the misuse of reviews. This quality meta-review intends to summarize the results of all systematic reviews and meta-analyses that have been published on MRONJ in relation to genetic and pharmacogenomics risk factors. Methods: The research study protocol was registered into the database of the International Network for the Registration of Systematic Reviews and Meta-Analyses (INPLASY) INPLASY202230002. A comprehensive search across several databases (PubMed, EMBASE, MEDLINE, and CINAHL) was conducted to locate multi-language papers published between January 2003 and November 2022. Data were collected from relevant research studies and appraised in accordance with the precise outcomes described in this evaluation. Results: Only five systematic reviews and meta-analyses were analysed in this meta-review. All the reviews included in this research presented qualities mistakes and shortcomings. Two quality assessment tools (Confidence in Evidence from Reviews of Qualitative research (CERQual) and Assessment of Multiple Systematic Reviews 2 (AMSTAR-2)) were used to evaluate each study included in this research. Conclusions: The data evaluated by this meta-review confirmed the poor-quality secondary research underpinning the genetic/pharmacogenomics aspect of MRONJ. Moreover, this study highlighted the many flaws of the current published systematic and meta-analysis studies published so far.

artículo de revisión

10.3390/app122312289

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MRONJ

genetic

osteonecrosis

pharmacogenomics

evidence-based medicine

meta-review

BISPHOSPHONATE-RELATED OSTEONECROSIS

SURGEONS POSITION PAPER

MULTIPLE-MYELOMA

AMERICAN ASSOCIATION

CANCER-PATIENTS

RISK-FACTORS

POLYMORPHISM

RECOMMENDATIONS

PREVENTION

MANAGEMENT

Química Multidisciplinaria

Ingeniería Multidisciplinaria

Ciencia de Materiales

Multidisciplinaria

Física Aplicada

MRONJ

genética

osteonecrosis

farmacogenómica

medicina basada en evidencia

meta-revisión

OSTEONECROSIS RELACIONADA CON BISFOSFONATO

DOCUMENTO DE POSICIÓN DE LOS CIRUJANOS

MIELOMA MÚLTIPLE

ASOCIACIÓN AMERICANA

PACIENTES CON CÁNCER

FACTORES DE RIESGO

POLIMORFISMO

RECOMENDACIONES

PREVENCIÓN

MANEJO

Odontología, Cirugía y Medicina Oral

Genética y Herencia

Farmacología y Farmacia

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WOS:000895343200001

A Comprehensive Quality Meta-Review of Genetic and Pharmacogenomic Aspects of Medication-Related Osteonecrosis of The Jaw (MRONJ)

artículo de revisión

CC BY 4.0

CC BY 4.0