A Comprehensive Quality Meta-Review of Genetic and Pharmacogenomic Aspects of Medication-Related Osteonecrosis of The Jaw (MRONJ)

Primer Autor
Sacco, Roberto
Co-autores
Olate, Sergio
Calasans-Maia, Monica Diuana
Sacco, Nicola
Acocella, Alessandro
Mourao, Carlos Fernando De Almeida Barros
Moraschini, Vittorio
Akintola, Oladapo
Guerra, Raphael Capelli
Yates, Julian
Título
A Comprehensive Quality Meta-Review of Genetic and Pharmacogenomic Aspects of Medication-Related Osteonecrosis of The Jaw (MRONJ)
Editorial
MDPI
Revista
APPLIED SCIENCES-BASEL
Lenguaje
en
Resumen
Background: Antiresorptive and antiangiogenic medications can cause a serious adverse effect known as medication-related osteonecrosis of the jaw (MRONJ). In recent years, a new trend of research has emerged emphasizing the potential relation of MRONJ and genetic predisposition. Current evidence-based science of this adverse reaction is associated with poorly performed studies. Additionally, MRONJ research has recently observed a new trend of studies orientated towards the misuse of reviews. This quality meta-review intends to summarize the results of all systematic reviews and meta-analyses that have been published on MRONJ in relation to genetic and pharmacogenomics risk factors. Methods: The research study protocol was registered into the database of the International Network for the Registration of Systematic Reviews and Meta-Analyses (INPLASY) INPLASY202230002. A comprehensive search across several databases (PubMed, EMBASE, MEDLINE, and CINAHL) was conducted to locate multi-language papers published between January 2003 and November 2022. Data were collected from relevant research studies and appraised in accordance with the precise outcomes described in this evaluation. Results: Only five systematic reviews and meta-analyses were analysed in this meta-review. All the reviews included in this research presented qualities mistakes and shortcomings. Two quality assessment tools (Confidence in Evidence from Reviews of Qualitative research (CERQual) and Assessment of Multiple Systematic Reviews 2 (AMSTAR-2)) were used to evaluate each study included in this research. Conclusions: The data evaluated by this meta-review confirmed the poor-quality secondary research underpinning the genetic/pharmacogenomics aspect of MRONJ. Moreover, this study highlighted the many flaws of the current published systematic and meta-analysis studies published so far.
Tipo de Recurso
artículo de revisión
doi
10.3390/app122312289
Formato Recurso
PDF
Palabras Claves
MRONJ
genetic
osteonecrosis
pharmacogenomics
evidence-based medicine
meta-review
BISPHOSPHONATE-RELATED OSTEONECROSIS
SURGEONS POSITION PAPER
MULTIPLE-MYELOMA
AMERICAN ASSOCIATION
CANCER-PATIENTS
RISK-FACTORS
POLYMORPHISM
RECOMMENDATIONS
PREVENTION
MANAGEMENT
Ubicación del archivo
http://dx.doi.org/10.3390/app122312289
Categoría OCDE
Química Multidisciplinaria
Ingeniería Multidisciplinaria
Ciencia de Materiales
Multidisciplinaria
Física Aplicada
Materias
MRONJ
genética
osteonecrosis
farmacogenómica
medicina basada en evidencia
meta-revisión
OSTEONECROSIS RELACIONADA CON BISFOSFONATO
DOCUMENTO DE POSICIÓN DE LOS CIRUJANOS
MIELOMA MÚLTIPLE
ASOCIACIÓN AMERICANA
PACIENTES CON CÁNCER
FACTORES DE RIESGO
POLIMORFISMO
RECOMENDACIONES
PREVENCIÓN
MANEJO
Título de la cita (Recomendado-único)
A Comprehensive Quality Meta-Review of Genetic and Pharmacogenomic Aspects of Medication-Related Osteonecrosis of The Jaw (MRONJ)
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000895343200001
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Colección Publicaciones Científicas
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