Pluripotent Core in Bovine Embryos: A Review

Primer Autor
Aguila, Luis
Co-autores
Osycka-Salut, Claudia
Treulen, Favian
Felmer, Ricardo
Título
Pluripotent Core in Bovine Embryos: A Review
Editorial
MDPI
Revista
ANIMALS
Lenguaje
en
Resumen
Simple Summary The fusion between sperm and oocyte results in a zygote, which is a single totipotent cell with the ability to develop into a functional organism. Totipotent cells can give rise to different specialized cell types of all lineages. Understanding the interactions between cell signaling pathways, which drive the early embryo to maintain pluripotency, is essential to establishing the optimal embryonic or stem cell culture conditions for biotechnological applications in cattle. Thus, this review summarizes the core of pluripotency genes, strategies for controlling pluripotency, and the potential applications of pluripotency in in vitro production of cattle embryos. Early development in mammals is characterized by the ability of each cell to produce a complete organism plus the extraembryonic, or placental, cells, defined as pluripotency. During subsequent development, pluripotency is lost, and cells begin to differentiate to a particular cell fate. This review summarizes the current knowledge of pluripotency features of bovine embryos cultured in vitro, focusing on the core of pluripotency genes (OCT4, NANOG, SOX2, and CDX2), and main chemical strategies for controlling pluripotent networks during early development. Finally, we discuss the applicability of manipulating pluripotency during the morula to blastocyst transition in cattle species.
Tipo de Recurso
artículo de revisión
doi
10.3390/ani12081010
Formato Recurso
PDF
Palabras Claves
cattle
in vitro technologies
stem cells
IVF
LEUKEMIA INHIBITORY FACTOR
EARLY LINEAGE SEGREGATION
INNER CELL MASS
IN-VITRO
PREIMPLANTATION DEVELOPMENT
GENE-EXPRESSION
TROPHECTODERM LINEAGE
PRIMITIVE ENDODERM
NUCLEAR TRANSFER
STEM-CELLS
Ubicación del archivo
http://dx.doi.org/10.3390/ani12081010
Categoría OCDE
Agricultura
Lácteos y Ciencia Animal
Ciencias Veterinarias
Zoología
Materias
ganado
tecnologías in vitro
células madre
FIV
FACTOR INHIBIDOR DE LA LEUCEMIA
SEGREGACIÓN DEL LINAJE TEMPRANO
MASA CELULAR INTERNA
IN VITRO
DESARROLLO PREIMPLANTACIÓN
EXPRESIÓN GENÉTICA
LINAJE DEL TROFECTODERMO
ENDODERMO PRIMITIVO
TRANSFERENCIA NUCLEAR
CÉLULAS MADRE
Disciplinas de la OCDE
Biología Molecular
Biología del Desarrollo
Ciencias Veterinarias
Título de la cita (Recomendado-único)
Pluripotent Core in Bovine Embryos: A Review
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000785463500001
Colecciones
Colección Publicaciones Científicas
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