Endocrine disruptor chemicals. A review of their effects on male reproduction and antioxidants as a strategy to counter it

Primer Autor
Villegas, Juana V.
Co-autores
Quilaqueo, Nelson
Título
Endocrine disruptor chemicals. A review of their effects on male reproduction and antioxidants as a strategy to counter it
Editorial
WILEY
Revista
ANDROLOGIA
Lenguaje
en
Resumen
Endocrine disruptor chemicals are exogenous molecules that generate adverse effects on human health by destabilizing the homeostasis of endocrine system and affecting directly human reproductive system by inhibiting or activating oestrogenic or androgenic receptors. Endocrine disruptor chemicals generate transgenerational epigenetic problems, besides being associated with male infertility. Epidemiological data indicate that the increase in reproductive problems in males in the last 50 years is correlated with the increase of endocrine disrupting chemicals in the environment, being associated with a decrease in semen quality and direct effects on spermatozoa, such as alterations in motility, viability and acrosomal reaction, due to the generation of oxidative stress, and have also been postulated as a possible cause of testicular dysgenesis syndrome. Diverse antioxidants, such as C and E vitamins, N-acetylcysteine, selenium and natural vegetable extracts, are among the alternatives under study to counter the effects of endocrine disruptor chemicals. In some cases, the usage of them has given positive results and the opposite in others. In this review, we summarize the recent information about the effects of endocrine disruptor chemicals on male reproduction, on sperm cells, and the results of studies that have tested antioxidants as a strategy to diminish their harmful effects.
Tipo de Recurso
artículo de revisión
doi
10.1111/and.14302
Formato Recurso
PDF
Palabras Claves
male infertility
oxidative stress
OXYGEN SPECIES GENERATION
BISPHENOL-A
OXIDATIVE STRESS
NATURAL ANTIOXIDANTS
HUMAN SPERMATOZOA
METHYL PARATHION
MALE-INFERTILITY
SPERM FUNCTION
TOXICITY
APOPTOSIS
Ubicación del archivo
http://dx.doi.org/10.1111/and.14302
Categoría OCDE
Andrología
Materias
infertilidad masculina
estrés oxidativo
GENERACIÓN DE ESPECIES DE OXÍGENO
BISFENOL-A
ESTRÉS OXIDATIVO
ANTIOXIDANTES NATURALES
ESPERMATOZOOS HUMANOS
PARATION METIL
INFERTILIDAD MASCULINA
FUNCIÓN DEL ESPERMA
TOXICIDAD
APOPTOSIS
Disciplinas de la OCDE
Biología Reproductiva
Toxicología
Andrología
Título de la cita (Recomendado-único)
Endocrine disruptor chemicals. A review of their effects on male reproduction and antioxidants as a strategy to counter it
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
Derechos de acceso
restringido
Access Rights
restringido
Id de Web of Science
WOS:000716948800001
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