The family of kallikrein-related peptidases and kinin peptides as modulators of epidermal homeostasis

Primer Autor
Figueroa, Carlos D.
Co-autores
Matus, Carola E.
Ehrenfeld, Pamela
Título
The family of kallikrein-related peptidases and kinin peptides as modulators of epidermal homeostasis
Editorial
AMER PHYSIOLOGICAL SOC
Revista
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
Lenguaje
en
Resumen
The epidermis is the outermost skin layer and is part of one of the largest organs in the body, it is supported by the dermis, a network of fibrils, blood vessels, pilosebaceous units, sweat glands, nerves, and cells. The skin as a whole is a protective shield against numerous noxious agents, including microorganisms and chemical and physical factors. These functions rely on the ac-tivity of multiple growth factors, peptide hormones, proteases, and specific signaling pathways that are triggered by the activa-tion of distinct types of receptors sited in the cell membranes of the various cell types present in the skin. The human kallikrein family comprises a large group of 15 serine proteases synthesized and secreted by different types of epithelial cells throughout the body, including the skin. At this site, they initiate a proteolytic cascade that generates the active forms of the proteases, some of which regulate skin desquamation, activation of cytokines, and antimicrobial peptides. Kinin peptides are formed by the action of plasma and tissue kallikreins on kininogens, two plasma proteins produced in the liver and other organs. Although kinins are well known for their proinflammatory abilities, in the skin they are also considered important modulators of keratino-cyte differentiation. In this review, we summarize the contributions of the kallikreins and kallikrein-related peptidases family and those of kinins and their receptors in skin homeostasis, with special emphasis on their pathophysiological role.
Tipo de Recurso
artículo de revisión
Description
This work was supported by grants No DI22-0061 (to C.E.M.)from Universidad de La Frontera, Temuco, Chile and Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) 1201635 (to P.E.) from the National Agency for Research and Development (ANID, Chile).
doi
10.1152/ajpcell.00012.2022
Formato Recurso
PDF
Palabras Claves
bradykinin
kallikrein-related peptidases
keratinocyte
kinin B1 receptor
kinin B2 receptor
CORNEUM CHYMOTRYPTIC ENZYME
SERINE-PROTEASE INHIBITOR
TISSUE-SPECIFIC EXPRESSION
HUMAN SWEAT GLANDS
STRATUM-CORNEUM
HUMAN SKIN
ANTIMICROBIAL PEPTIDES
HUMAN KERATINOCYTES
ATOPIC-DERMATITIS
NETHERTON-SYNDROME
Ubicación del archivo
http://dx.doi.org/10.1152/ajpcell.00012.2022
Categoría OCDE
Biología Celular
Fisiología
Materias
bradicinina
peptidasas relacionadas con calicreína
queratinocitos
receptor de cinina B1
receptor de cinina B2
ENZIMA QUIMOTRÍPTICA DEL CÓRNEO
INHIBIDOR DE LA PROTEASEA DE SERINA
EXPRESIÓN ESPECÍFICA DEL TEJIDO
GLÁNDULAS SUDORÍFICAS HUMANAS
ESTRATO CORNEO
PIEL HUMANA
PEPTIDOS ANTIMICROBIANOS
QUERATINOCITOS HUMANOS
ATOPIC- DERMATITIS
SÍNDROME DE NETHERTON
Disciplinas de la OCDE
Bioquímica
Biología Celular
Dermatología y Enfermedades Venéreas
Título de la cita (Recomendado-único)
The family of kallikrein-related peptidases and kinin peptides as modulators of epidermal homeostasis
Página de inicio (Recomendado-único)
C1070
Página final (Recomendado-único)
C1087
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
version publicada
Condición de la licencia (Recomendado-repetible)
0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Identificador relacionado
PubMed35993513
Referencia del Financiador (Mandatado si es aplicable-repetible)
UFRO DI22-0061
ANID-FONDECYT 1201635
ANID FONDECYT 1201635
Id de Web of Science
WOS:000871073500007
Colecciones
Colección Publicaciones Científicas
Colección ANID
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