Repositorio UFRO · Omeka S

How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review

Primer Autor	Lezcano, Maria Florencia
Co-autores	Marquez, Alex Lopez Emilio Gareis, Ivan Jose Dias, Fernando Gerhard, Christoph
Título	How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review
Editorial	MDPI
Revista	POLYMERS
Lenguaje	en
Resumen	Electrospun scaffolds have a 3D fibrous structure that attempts to imitate the extracellular matrix in order to be able to host cells. It has been reported in the literature that controlling fiber surface topography produces varying results regarding cell-scaffold interactions. This review analyzes the relevant literature concerning in vitro studies to provide a better understanding of the effect that controlling fiber surface topography has on cell-scaffold interactions. A systematic approach following PRISMA, GRADE, PICO, and other standard methodological frameworks for systematic reviews was used. Different topographic interventions and their effects on cell-scaffold interactions were analyzed. Results indicate that nanopores and roughness on fiber surfaces seem to improve proliferation and adhesion of cells. The quality of the evidence is different for each studied cell-scaffold interaction, and for each studied morphological attribute. The evidence points to improvements in cell-scaffold interactions on most morphologically complex fiber surfaces. The discussion includes an in-depth evaluation of the indirectness of the evidence, as well as the potentially involved publication bias. Insights and suggestions about dose-dependency relationship, as well as the effect on particular cell and polymer types, are presented. It is concluded that topographical alterations to the fiber surface should be further studied, since results so far are promising.
Fecha Publicación	2022
Tipo de Recurso	artículo de revisión
Derecho de Acceso	Acceso abierto
doi	10.3390/polym14010209
Formato Recurso	PDF
Palabras Claves	electrospun scaffold topography fiber surface cell proliferation cell adhesion cell differentiation nanoporosity nanotopography surface morphology
Ubicación del archivo	http://dx.doi.org/10.3390/polym14010209
Categoría OCDE	Ciencia de los polímeros
Materias	andamio electrohilado topografía superficie de la fibra proliferación celular Adhesión celular celúla diferenciación nanoporosidad nanotopografía morfología de la superficie
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000916185600001
Tipo de ruta	verde# dorado
Categoría WOS	Ciencia de los polímeros