Repositorio UFRO · Omeka S

Pharmacogenomics of mycophenolic acid in kidney transplantation: Contribution of immune response-related genes

Primer Autor	Hirata, Rosario Dominguez Crespo
Co-autores	Genvigir, Fabiana Dalla Vecchia Hirata, Thiago Dominguez Crespo Cerda, Alvaro Hirata, Mario Hiroyuki
Título	Pharmacogenomics of mycophenolic acid in kidney transplantation: Contribution of immune response-related genes
Editorial	UNIV SAO PAULO, CONJUNTO QUIMICAS
Revista	BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Lenguaje	en
Resumen	Mycophenolic acid (MPA) inhibits IMPDH, involved in the guanosine nucleotides synthesis, and prevents DNA replication in immune cells. The repression of cell and humoral immunity by MPA induces allograft tolerance preventing acute rejection in solid organ transplantation. MPA is an effective and safe drug, but genetic and non-genetic factors have been implicated in the interindividual variability of drug response. Several studies have shown the impact of variants of pharmacokinetics or pharmacodynamics-related genes on MPA response in kidney transplantation. This review explored further the influence of genes involved in the immune response on clinical outcomes of kidney recipients on short-or long-term MPA treatment. Variants in genes related to T cell activation (CD28, CTL4, ICOS, PDPC1), pro-inflammatory cytokines (IL2, IL6, IL12A, IL12B, TNF, IFNG), immunomodulatory cytokines (IL4, IL10, TGFB1), and innate immune response (CD14, TLR2, TLR4) were shown to be associated with increased risk of acute rejection, graft function or survival, chronic graft nephropathy, viral infections or MPA-induced myelotoxicity. Some of the significant pharmacogenetic associations were confirmed by meta-analyses of kidney transplantation. These findings are suggestive that variants in immune response-related genes contribute to the variability of MPA response, and have potential application as biomarkers of acute rejection in kidney transplantation.
Fecha Publicación	2022
Tipo de Recurso	artículo original
doi	10.1590/s2175-97902022e201188
Formato Recurso	PDF
Palabras Claves	Immunosuppressive therapy Mycophenolic acid Kidney transplantation Pharmacogenomics Immune response
Ubicación del archivo	http://dx.doi.org/10.1590/s2175-97902022e201188
Categoría OCDE	Farmacología y farmacia
Materias	Terapia inmunosupresora Ácido micofenólico Trasplante de riñón Farmacogenómica Respuesta inmune
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000919890100001
ISSN	1984-8250
Tipo de ruta	Verde# dorado
Categoría WOS	Farmacología y farmacia