Design of a separation process for natural 2-phenylethanol with solvent selection based on safety criteria
| Primer Autor |
Lopez-Molina, Antioco
|
| Co-autores |
Chacon-Izquierdo, Alejandro
Magdaleno-Cruz, Ana E.
Conde-Baez, Laura
Mas-Hernandez, Elizabeth
Conde-Mejia, Carolina
|
| Título |
Design of a separation process for natural 2-phenylethanol with solvent selection based on safety criteria
|
| Editorial |
WILEY
|
| Revista |
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
|
| Lenguaje |
en
|
| Resumen |
BACKGROUND: In the past, process safety has improved safety issues in chemical plants, today, it is essential to consider safety aspects in any process plant. Furthermore, the production of value-added products through biotechnological methods has increased, and safety is usually not considered in this kind of process design. The biotechnological production of 2-phenylethanol (2-PE) has been studied at a laboratory scale. However, before considering industrial-scale production, it is necessary to design an efficient and safe purification process to maintain the quality characteristics of 2-PE. This work proposes a separation process for natural 2-PE (which was obtained from whey fermentation) and evaluates its safety and economic aspects. RESULTS: This process is based on liquid-liquid extraction. The feed stream consists of an aqueous mixture with 0.095 wt% of 2-PE and 1.54 wt% of ethanol. The conceptual design was implemented in the simulator Aspen Plus V.10. The bioprocess safety index (BPSI) was used to find the hazardous process streams for the safety evaluation. CONCLUSION: The 2-PE separation showed an overall recovery of 99.54% and a purity of 99.67 wt% in the product stream. The process streams identified as hazardous are the extract and solvent recycling streams. The utility and operating cost per separated kilogram of 2-PE are USD 0.658 kg(-1) and USD 14.48 kg(-1), respectively. The industrial-scale implementation of 2-PE bioproduction shows positive potential. (c) 2022 Society of Chemical Industry (SCI).
|
| Fecha Publicación |
2022
|
| Tipo de Recurso |
artículo original
|
| Derecho de Acceso |
registro bibliográfico
|
| doi |
10.1002/jctb.7081
|
| Formato Recurso |
PDF
|
| Palabras Claves |
liquid-liquid extraction
process design
residues
simulation
|
| Ubicación del archivo | |
| Categoría OCDE |
Biotecnología y Microbiología Aplicada
Química
Ingeniería
Biotecnología Relacionada con la Salud
Química Analítica
Tecnología de Modificación Genética
|
| Materias |
extracción líquido-líquido
diseño de procesos
residuos
simulación
|
| Página de inicio (Recomendado-único) |
2103.0
|
| Página final (Recomendado-único) |
2108
|
| Identificador del recurso (Mandatado-único) |
artículo original
|
| Versión del recurso (Recomendado-único) |
versión publicada
|
| Derechos de acceso |
metadata
|
| Access Rights |
metadata
|
| Id de Web of Science |
WOS:000782584300001
|
| ISSN |
0268-2575
|
| Categoría WOS |
Biotecnología y Microbiología Aplicada
Química
Ingeniería
Ciencias de la Información y Bioinformática
|
| Referencia del Financiador (Mandatado si es aplicable-repetible) |
PRODEP UJAT-PTC-293
ANID FONDECYT 3200839
|
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