Repositorio
Institucional

Dias, Fernando Jose

Belen Alarcon, Josefa

Belen Chuhuaicura, Priscila

Anne Sluka, Kathleen

Vance, Carol G. T.

Sasoli Fazan, Valeria Paula

Alejandra Godoy, Karina

Eduardo Fuentes, Ramon

Transcutaneous Electrical Nerve Stimulation in Nerve Regeneration: A Systematic Review of In Vivo Animal Model Studies

ELSEVIER

NEUROMODULATION

en

Objective: Transcutaneous electrical nerve stimulation (TENS) is a noninvasive electrical stimulation therapy indicated for pain control that has been applied for the regeneration of nerves. This systematic review aimed to analyze the evidence on TENS effectiveness on nerve regeneration. Materials and Methods: A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria: PubMed/MEDLINE, Web of Science, ScienceDirect, and SciELO data bases. Primary research that evaluated TENS on nerve regeneration was considered. Results: Several studies have investigated the use of TENS for pain treatment. A total of six animal studies analyzed TENS for nerve regeneration. The selected articles showed high quality (Animal Research: Reporting of In Vivo Experiments guidelines), with many unclear points related to bias opportunities (Systematic Review Center for Laboratory Animal Experimentation Risk of Bias tool). In general, TENS accelerated functional and motor recovery and increased axon quantity and diameter. More specifically, the application of low-frequency TENS resulted in a continuous basal lamina, a higher density of fibers with normal diameters, indicating normal myelination, showed signs of deterioration and delayed nerve regeneration. In contrast, the high-frequency TENS application stimulated motor regeneration and increased the diameter of the regenerated axons but revealed a small number of axons, demyelination, dark axoplasm, and an increase in the predisposition of neuropathic pain. Conclusions: Although there is some heterogeneous evidence in animal research, TENS seems to be a promising treatment for nerve injury that should be better explored. It is still necessary to improve the analysis of its application parameters, which can lead to the most satisfactory regeneration results and improve the understanding of its mechanisms on peripheral nerve

2022

artículo de revisión

10.1016/j.neurom.2021.12.009

PDF

Electrical stimulation

nerve regeneration

physical therapy

rehabilitation

TENS

Investigación y Medicina Experimental

Neurociencias y Neurología

Estimulación eléctrica

regeneración nerviosa

terapia física

rehabilitación

TENS

1248.0

1258

artículo de revisión

versión publicada

metadata

metadata

WOS:000904207800020

1094-7159

Investigación y Medicina Experimental

Neurociencias y Neurología

ANID FONDECYT 11190300

UFRO 19-0065