Transcutaneous Electrical Nerve Stimulation in Nerve Regeneration: A Systematic Review of In Vivo Animal Model Studies
| Primer Autor |
Dias, Fernando Jose
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| Co-autores |
Belen Alarcon, Josefa
Belen Chuhuaicura, Priscila
Anne Sluka, Kathleen
Vance, Carol G. T.
Sasoli Fazan, Valeria Paula
Alejandra Godoy, Karina
Eduardo Fuentes, Ramon
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| Título |
Transcutaneous Electrical Nerve Stimulation in Nerve Regeneration: A Systematic Review of In Vivo Animal Model Studies
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| Editorial |
ELSEVIER
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| Revista |
NEUROMODULATION
|
| Lenguaje |
en
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| Resumen |
Objective: Transcutaneous electrical nerve stimulation (TENS) is a noninvasive electrical stimulation therapy indicated for pain control that has been applied for the regeneration of nerves. This systematic review aimed to analyze the evidence on TENS effectiveness on nerve regeneration. Materials and Methods: A systematic review was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria: PubMed/MEDLINE, Web of Science, ScienceDirect, and SciELO data bases. Primary research that evaluated TENS on nerve regeneration was considered. Results: Several studies have investigated the use of TENS for pain treatment. A total of six animal studies analyzed TENS for nerve regeneration. The selected articles showed high quality (Animal Research: Reporting of In Vivo Experiments guidelines), with many unclear points related to bias opportunities (Systematic Review Center for Laboratory Animal Experimentation Risk of Bias tool). In general, TENS accelerated functional and motor recovery and increased axon quantity and diameter. More specifically, the application of low-frequency TENS resulted in a continuous basal lamina, a higher density of fibers with normal diameters, indicating normal myelination, showed signs of deterioration and delayed nerve regeneration. In contrast, the high-frequency TENS application stimulated motor regeneration and increased the diameter of the regenerated axons but revealed a small number of axons, demyelination, dark axoplasm, and an increase in the predisposition of neuropathic pain. Conclusions: Although there is some heterogeneous evidence in animal research, TENS seems to be a promising treatment for nerve injury that should be better explored. It is still necessary to improve the analysis of its application parameters, which can lead to the most satisfactory regeneration results and improve the understanding of its mechanisms on peripheral nerve
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| Fecha Publicación |
2022
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| Tipo de Recurso |
artículo de revisión
|
| doi |
10.1016/j.neurom.2021.12.009
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| Formato Recurso |
PDF
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| Palabras Claves |
Electrical stimulation
nerve regeneration
physical therapy
rehabilitation
TENS
|
| Ubicación del archivo | |
| Categoría OCDE |
Investigación y Medicina Experimental
Neurociencias y Neurología
|
| Materias |
Estimulación eléctrica
regeneración nerviosa
terapia física
rehabilitación
TENS
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| Página de inicio (Recomendado-único) |
1248.0
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| Página final (Recomendado-único) |
1258
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| Identificador del recurso (Mandatado-único) |
artículo de revisión
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| Versión del recurso (Recomendado-único) |
versión publicada
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| Derechos de acceso |
metadata
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| Access Rights |
metadata
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| Id de Web of Science |
WOS:000904207800020
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| ISSN |
1094-7159
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| Categoría WOS |
Investigación y Medicina Experimental
Neurociencias y Neurología
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID FONDECYT 11190300
UFRO 19-0065
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cienciaabierta.ufro.cl
ciencia.abierta@ufrontera.cl