Repositorio
Institucional

Fratantonio, Deborah.

Butnariu, Monica.

Herrera-Bravo, Jesus.

Sukreet, Sonal.

Martorell, Miquel.

Robertovna, Garsiya Ekaterina.

Les, Francisco.

Lopez, Victor.

Kumar, Manoj.

Pentea, Marius.

Sarac, Ioan.

Becherescu, Alexandra.

Cruz-Martins, Natalia.

Setzer, William N.

Iriti, Marcello

Suleria, Hafiz Ansar Rasul

Sharifi-Rad, Javad

Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies

BENTHAM SCIENCE PUBL LTD

CURRENT TOPICS IN MEDICINAL CHEMISTRY

en

A sedentary lifestyle has evoked a high risk of cardiovascular (CV) disease, diabetes, and obesity, all of them with high morbimortality rates and with a common denominator, hypertension. Numerous pharmacological drugs have been used for the treatment of hypertension. However, the side effects associated with the use of existing pharmacological therapies have triggered a demand for plant-based medications. In this connection, the aim of this review was to provide an in-depth analysis of the use of plant-derived bioactives for the effective management of hypertension. Phytoconstituents from leaves, bark, stem, roots, seeds, and fruits of medicinal plants grown in our different regions of the globe have been highly searched. Among them, polyphenols (e.g., flavonoids as quercetin, anthocyanins as cyanidin, tannins as ellagic acid, stilbenes as resveratrol, lignans as honokiol and others as hydroxytyrosol or curcumin), organosulfur compounds (e.g. s-allyl cysteine and allicin), fatty acids (e.g. & alpha,-lipoic acid, DHA and oleic acid), alkaloids (e.g. berberine or tetrandrine) and some terpenes have been intensively investigated for the management of hypertension, with effective ability being stated in controlling high blood pressure and related health problems both in vivo and in vitro studies. Some of the activities presented by these bioactive compounds are reducing oxidative stress, renin-angiotensin system control, SIRT1 activation, regulating platelet aggregation and COX activity, anti-atherogenic effects, anti-inflammatory properties, vasorelaxation and other results that translate into the prevention or control of hypertension. The knowledge of these bioactive compounds is important in developing countries where traditional medicine is the majority, but it can also give rise to new approaches in hypertension therapy.

2023

artículo original

10.2174/1568026623666230106144509

PDF

Hypertension

Phytoconstituents

Phenolic compounds

Organosulfur compounds

Fatty acids

Traditional medicine

Pharmacological therapies

Nutraceuticals

Functional foods

Farmacología y farmacia

Hipertensión

Fitoconstituyentes

Compuestos fenólicos

Compuestos organosulfurados

Ácidos grasos

Medicina tradicional

Terapias farmacológicas

nutracéuticos

Alimentos funcionales

589.0

617

artículo original

versión publicada

metadata

metadata

WOS:001025440900001

1568-0266

Farmacología y farmacia