Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies

Primer Autor
Fratantonio, Deborah.
Co-autores
Butnariu, Monica.
Herrera-Bravo, Jesus.
Sukreet, Sonal.
Martorell, Miquel.
Robertovna, Garsiya Ekaterina.
Les, Francisco.
Lopez, Victor.
Kumar, Manoj.
Pentea, Marius.
Sarac, Ioan.
Becherescu, Alexandra.
Cruz-Martins, Natalia.
Setzer, William N.
Iriti, Marcello
Suleria, Hafiz Ansar Rasul
Sharifi-Rad, Javad
Título
Plant-food-derived Bioactives in Managing Hypertension: From Current Findings to Upcoming Effective Pharmacotherapies
Editorial
BENTHAM SCIENCE PUBL LTD
Revista
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Lenguaje
en
Resumen
A sedentary lifestyle has evoked a high risk of cardiovascular (CV) disease, diabetes, and obesity, all of them with high morbimortality rates and with a common denominator, hypertension. Numerous pharmacological drugs have been used for the treatment of hypertension. However, the side effects associated with the use of existing pharmacological therapies have triggered a demand for plant-based medications. In this connection, the aim of this review was to provide an in-depth analysis of the use of plant-derived bioactives for the effective management of hypertension. Phytoconstituents from leaves, bark, stem, roots, seeds, and fruits of medicinal plants grown in our different regions of the globe have been highly searched. Among them, polyphenols (e.g., flavonoids as quercetin, anthocyanins as cyanidin, tannins as ellagic acid, stilbenes as resveratrol, lignans as honokiol and others as hydroxytyrosol or curcumin), organosulfur compounds (e.g. s-allyl cysteine and allicin), fatty acids (e.g. & alpha,-lipoic acid, DHA and oleic acid), alkaloids (e.g. berberine or tetrandrine) and some terpenes have been intensively investigated for the management of hypertension, with effective ability being stated in controlling high blood pressure and related health problems both in vivo and in vitro studies. Some of the activities presented by these bioactive compounds are reducing oxidative stress, renin-angiotensin system control, SIRT1 activation, regulating platelet aggregation and COX activity, anti-atherogenic effects, anti-inflammatory properties, vasorelaxation and other results that translate into the prevention or control of hypertension. The knowledge of these bioactive compounds is important in developing countries where traditional medicine is the majority, but it can also give rise to new approaches in hypertension therapy.
Fecha Publicación
2023
Tipo de Recurso
artículo original
doi
10.2174/1568026623666230106144509
Formato Recurso
PDF
Palabras Claves
Hypertension
Phytoconstituents
Phenolic compounds
Organosulfur compounds
Fatty acids
Traditional medicine
Pharmacological therapies
Nutraceuticals
Functional foods
Ubicación del archivo
Categoría OCDE
Farmacología y farmacia
Materias
Hipertensión
Fitoconstituyentes
Compuestos fenólicos
Compuestos organosulfurados
Ácidos grasos
Medicina tradicional
Terapias farmacológicas
nutracéuticos
Alimentos funcionales
Página de inicio (Recomendado-único)
589.0
Página final (Recomendado-único)
617
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
versión publicada
Derechos de acceso
metadata
Access Rights
metadata
Id de Web of Science
WOS:001025440900001
ISSN
1568-0266
Categoría WOS
Farmacología y farmacia
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