Repositorio UFRO · Omeka S

Alcohol Intake as a Risk Factor for Acute Stroke: The INTERSTROKE Study

Primer Autor	Smyth, Andrew
Co-autores	O'Donnell, Martin Rangarajan, Sumathy Hankey, Graeme J. Oveisgharan, Shahram Canavan, Michelle McDermott, Clodagh Xavier, Denis Zhang, Hongye Damasceno, Albertino Avezum, Alvaro Pogosova, Nana Oguz, Aytekin Ryglewicz, Danuta Iversen, Helle Klingenberg Lanas, Fernando Rosengren, Annika Yusuf, Salim Langhorne, Peter
Título	Alcohol Intake as a Risk Factor for Acute Stroke: The INTERSTROKE Study
Editorial	LIPPINCOTT WILLIAMS & WILKINS
Revista	NEUROLOGY
Lenguaje	en
Resumen	Background and ObjectivesThere is uncertainty about the association between alcohol consumption and stroke, particularly for low-moderate intake. We explored these associations in a large international study. MethodsINTERSTROKE, a case-control study, is the largest international study of risk factors for acute stroke. Alcohol consumption was self-reported and categorized by drinks/week as low (1-7), moderate (7-14 for females and 7-21 for males), or high (>14 for females and >21 for males). Heavy episodic drinking (HED) was defined as >5 drinks on >= 1 day per month. Multivariable conditional logistic regression was used to determine associations. ResultsWe included 12,913 cases and 12,935 controls, 25.0% (n = 6,449) were current drinkers, 16.7% (n = 4,318) former drinkers, and 58.3% (n = 15,076) never drinkers. Current drinkers were younger, male, smokers, active, and with higher-paid occupations. Current drinking was associated with all stroke (OR 1.14, 95% CI 1.04-1.26) and intracerebral hemorrhage (ICH) (OR 1.50, 95% CI 1.21-1.84) but not ischemic stroke (OR 1.06, 95% CI 0.95-1.19). HED pattern was associated with all stroke (OR 1.39, 95% CI 1.21-1.59), ischemic stroke (OR 1.29, 95% CI 1.10-1.51), and ICH (OR 1.76, 95% CI 1.31-2.36). High level of alcohol intake was consistently associated with all stroke, ischemic stroke, and ICH. Moderate intake was associated with all stroke and ICH but not ischemic stroke. Low alcohol intake was not associated with stroke overall, but there were regional differences, low intake was associated with reduced odds of stroke in Western Europe/North America (OR 0.66, 95% CI 0.45-0.96) and increased odds in India (OR 2.18, 95% CI 1.42-3.36) (p-interaction 0.037). Wine consumption was associated with reduced odds of all stroke and ischemic stroke but not ICH. The magnitudes of association were greatest in those without hypertension and current smokers. DiscussionHigh and moderate intake were associated with increased odds of stroke, whereas low intake was not associated with stroke. However, there were important regional variations, which may relate to differences in population characteristics of alcohol consumers, types or patterns of consumption.
Fecha Publicación	2023
Tipo de Recurso	artículo original
doi	10.1212/WNL.0000000000201388
Formato Recurso	PDF
Palabras Claves	Alcohol Drinking / adverse effects Alcohol Drinking / epidemiology Case-Control Studies Cerebral Hemorrhage / complications Cerebral Hemorrhage / epidemiology Female Humans Ischemic Stroke / complications Male Risk Factors Stroke / epidemiology Stroke / etiology
Ubicación del archivo	http://dx.doi.org/10.1212/WNL.0000000000201388
Categoría OCDE	Neurociencias y Neurología
Materias	Consumo de alcohol/efectos adversos Consumo de alcohol / epidemiología Estudios de casos y controles Hemorragia Cerebral/complicaciones Hemorragia Cerebral/epidemiología Femenino Humanos Accidente cerebrovascular isquémico/complicaciones Masculino Factores de riesgo Ictus/epidemiología Accidente cerebrovascular / etiología
Página final (Recomendado-único)	E153
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000928460700016
ISSN	0028-3878
Tipo de ruta	verde# hibrido
Categoría WOS	Neurociencias y Neurología