Repositorio
Institucional

Smyth, Andrew

O'Donnell, Martin

Rangarajan, Sumathy

Hankey, Graeme J.

Oveisgharan, Shahram

Canavan, Michelle

McDermott, Clodagh

Xavier, Denis

Zhang, Hongye

Damasceno, Albertino

Avezum, Alvaro

Pogosova, Nana

Oguz, Aytekin

Ryglewicz, Danuta

Iversen, Helle Klingenberg

Lanas, Fernando

Rosengren, Annika

Yusuf, Salim

Langhorne, Peter

Alcohol Intake as a Risk Factor for Acute Stroke: The INTERSTROKE Study

LIPPINCOTT WILLIAMS & WILKINS

NEUROLOGY

en

Background and ObjectivesThere is uncertainty about the association between alcohol consumption and stroke, particularly for low-moderate intake. We explored these associations in a large international study. MethodsINTERSTROKE, a case-control study, is the largest international study of risk factors for acute stroke. Alcohol consumption was self-reported and categorized by drinks/week as low (1-7), moderate (7-14 for females and 7-21 for males), or high (>14 for females and >21 for males). Heavy episodic drinking (HED) was defined as >5 drinks on >= 1 day per month. Multivariable conditional logistic regression was used to determine associations. ResultsWe included 12,913 cases and 12,935 controls, 25.0% (n = 6,449) were current drinkers, 16.7% (n = 4,318) former drinkers, and 58.3% (n = 15,076) never drinkers. Current drinkers were younger, male, smokers, active, and with higher-paid occupations. Current drinking was associated with all stroke (OR 1.14, 95% CI 1.04-1.26) and intracerebral hemorrhage (ICH) (OR 1.50, 95% CI 1.21-1.84) but not ischemic stroke (OR 1.06, 95% CI 0.95-1.19). HED pattern was associated with all stroke (OR 1.39, 95% CI 1.21-1.59), ischemic stroke (OR 1.29, 95% CI 1.10-1.51), and ICH (OR 1.76, 95% CI 1.31-2.36). High level of alcohol intake was consistently associated with all stroke, ischemic stroke, and ICH. Moderate intake was associated with all stroke and ICH but not ischemic stroke. Low alcohol intake was not associated with stroke overall, but there were regional differences, low intake was associated with reduced odds of stroke in Western Europe/North America (OR 0.66, 95% CI 0.45-0.96) and increased odds in India (OR 2.18, 95% CI 1.42-3.36) (p-interaction 0.037). Wine consumption was associated with reduced odds of all stroke and ischemic stroke but not ICH. The magnitudes of association were greatest in those without hypertension and current smokers. DiscussionHigh and moderate intake were associated with increased odds of stroke, whereas low intake was not associated with stroke. However, there were important regional variations, which may relate to differences in population characteristics of alcohol consumers, types or patterns of consumption.

2023

artículo original

10.1212/WNL.0000000000201388

PDF

Alcohol Drinking / adverse effects

Alcohol Drinking / epidemiology

Case-Control Studies

Cerebral Hemorrhage / complications

Cerebral Hemorrhage / epidemiology

Female

Humans

Ischemic Stroke / complications

Male

Risk Factors

Stroke / epidemiology

Stroke / etiology

Neurociencias y Neurología

Consumo de alcohol/efectos adversos

Consumo de alcohol / epidemiología

Estudios de casos y controles

Hemorragia Cerebral/complicaciones

Hemorragia Cerebral/epidemiología

Femenino

Humanos

Accidente cerebrovascular isquémico/complicaciones

Masculino

Factores de riesgo

Ictus/epidemiología

Accidente cerebrovascular / etiología

E153

artículo original

versión publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

WOS:000928460700016

0028-3878

verde# hibrido

Neurociencias y Neurología