Repositorio
Institucional

Salazar, Lorena

Pavon, Alequis

Corsini, Gino

Orellana, Paz

Calisto, Nancy

Navarro, Laura

Wiese, Guillermo

Cortes-Cortes, Piedad

Gidekel, Manuel

Gutierrez-Moraga, Ana

Identification of Antarctic Soil Bacteria Exhibiting Antiproliferative Activity Against a Colon Cancer Cell Line

SOC CHILENA ANATOMIA

INTERNATIONAL JOURNAL OF MORPHOLOGY

en

Cancer is the second leading cause of death in the world and colorectal cancer is the only cancer that has shown a sustained increase in mortality in the last decade. In the search for new chemotherapeutic agents against cancer, extremophilic microorganisms have shown to be a potential source to obtain molecules of natural origin and with selective cytotoxic action towards cancer cells. In this work we analyzed the ability of a collection of Antarctic soil bacteria, isolated on Collins Glacier from the rhizosphere ofDeschampsia antarctica Desv plant, to secrete molecules capable of inhibiting cell proliferation of a colorectal cancer tumor line. Our results demonstrated that culture supernatants from the Antarctic bacteria K2I17 and MI12 decreased the viability of LoVo cells, a colorectal adenocarcinoma cell line. Phenotypic and genotypic characterization of the Antarctic bacteria showed that they were taxonomically related and nucleotide identity analysis based on the 16S rRNA gene sequence identified the bacterium K2I17 as a species belonging to the genus Bacillus.

2023

artículo original

10.4067/S0717-95022023000100286

PDF

Antarctic bacteria

Antiproliferative activity

Colorectal cancer

Anatomía y Morfología

bacterias antárticas

Actividad antiproliferativa

Cáncer colonrectal

286.0

296

artículo original

versión publicada

acceso abierto

acceso abierto

WOS:000961353900039

0717-9502

verde# dorado

Anatomía y Morfología

UA GENERA-UA 2019-017