Identification of Antarctic Soil Bacteria Exhibiting Antiproliferative Activity Against a Colon Cancer Cell Line
| Primer Autor |
Salazar, Lorena
|
| Co-autores |
Pavon, Alequis
Corsini, Gino
Orellana, Paz
Calisto, Nancy
Navarro, Laura
Wiese, Guillermo
Cortes-Cortes, Piedad
Gidekel, Manuel
Gutierrez-Moraga, Ana
|
| Título |
Identification of Antarctic Soil Bacteria Exhibiting Antiproliferative Activity Against a Colon Cancer Cell Line
|
| Editorial |
SOC CHILENA ANATOMIA
|
| Revista |
INTERNATIONAL JOURNAL OF MORPHOLOGY
|
| Lenguaje |
en
|
| Resumen |
Cancer is the second leading cause of death in the world and colorectal cancer is the only cancer that has shown a sustained increase in mortality in the last decade. In the search for new chemotherapeutic agents against cancer, extremophilic microorganisms have shown to be a potential source to obtain molecules of natural origin and with selective cytotoxic action towards cancer cells. In this work we analyzed the ability of a collection of Antarctic soil bacteria, isolated on Collins Glacier from the rhizosphere ofDeschampsia antarctica Desv plant, to secrete molecules capable of inhibiting cell proliferation of a colorectal cancer tumor line. Our results demonstrated that culture supernatants from the Antarctic bacteria K2I17 and MI12 decreased the viability of LoVo cells, a colorectal adenocarcinoma cell line. Phenotypic and genotypic characterization of the Antarctic bacteria showed that they were taxonomically related and nucleotide identity analysis based on the 16S rRNA gene sequence identified the bacterium K2I17 as a species belonging to the genus Bacillus.
|
| Fecha Publicación |
2023
|
| Tipo de Recurso |
artículo original
|
| doi |
10.4067/S0717-95022023000100286
|
| Formato Recurso |
PDF
|
| Palabras Claves |
Antarctic bacteria
Antiproliferative activity
Colorectal cancer
|
| Ubicación del archivo | |
| Categoría OCDE |
Anatomía y Morfología
|
| Materias |
bacterias antárticas
Actividad antiproliferativa
Cáncer colonrectal
|
| Página de inicio (Recomendado-único) |
286.0
|
| Página final (Recomendado-único) |
296
|
| Identificador del recurso (Mandatado-único) |
artículo original
|
| Versión del recurso (Recomendado-único) |
versión publicada
|
| Derechos de acceso |
acceso abierto
|
| Access Rights |
acceso abierto
|
| Id de Web of Science |
WOS:000961353900039
|
| ISSN |
0717-9502
|
| Tipo de ruta |
verde# dorado
|
| Categoría WOS |
Anatomía y Morfología
|
| Referencia del Financiador (Mandatado si es aplicable-repetible) |
UA GENERA-UA 2019-017
|
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