Repositorio UFRO · Omeka S

Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation: Role of HIF-1α and Th17 Cells

Primer Autor	Salazar, Luis A.
Co-autores	Arias, Consuelo Sepulveda, Paulina Castillo, Rodrigo L.
Título	Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation: Role of HIF-1α and Th17 Cells
Editorial	MDPI
Revista	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje	en
Resumen	Neuroinflammation is a common event in degenerative diseases of the central and peripheral nervous system, triggered by alterations in the immune system or inflammatory cascade. The pathophysiology of these disorders is multifactorial, whereby the therapy available has low clinical efficacy. This review propounds the relationship between the deregulation of T helper cells and hypoxia, mainly Th17 and HIF-1 alpha molecular pathways, events that are involved in the occurrence of the neuroinflammation. The clinical expression of neuroinflammation is included in prevalent pathologies such as multiple sclerosis, Guillain-Barre syndrome, and Alzheimer's disease, among others. In addition, therapeutic targets are analyzed in relation to the pathways that induced neuroinflammation.
Fecha Publicación	2023
Tipo de Recurso	artículo de revisión
doi	10.3390/ijms24043073
Formato Recurso	PDF
Palabras Claves	neuroinflammation hypoxia Th17 HIF-1 alpha autoimmune diseases
Ubicación del archivo	http://dx.doi.org/10.3390/ijms24043073
Categoría OCDE	Bioquímica y biología molecular Química
Materias	neuroinflamación hipoxia Th17 HIF-1 alfa Enfermedades autoinmunes
Versión del recurso (Recomendado-único)	versión publicada
Tipo de ruta	dorada verde
Access Rights	acceso abierto
Derechos de acceso	acceso abierto
Id de Web of Science	WOS:000945527500001
Identificador del recurso (Mandatado-único)	artículo de revisión
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Categoría WOS	Bioquímica y biología molecular Química