High prevalence of lupin allergy among patients with peanut allergy Identification of-y -conglutin as major allergen
| Primer Autor |
Wandersleben, Traudy
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| Co-autores |
Aguilera-Insunza, Raquel
Iturriaga, Carolina
Marinanco, Angelica
Venegas, Luis
Aravena, Gabriela
Perez-Mateluna, Guillermo
Baptista-Dias, Nathalia
Borzutzky, Arturo
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| Título |
High prevalence of lupin allergy among patients with peanut allergy Identification of-y -conglutin as major allergen
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| Editorial |
ELSEVIER SCIENCE INC
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| Revista |
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
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| Lenguaje |
en
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| Resumen |
Background: Lupin is a protein-rich legume with a growing presence in the food market worldwide. With increased consumption, lupin allergy (LA) reports are also rising. Uncertainties exist on the cross-reactivity between peanut , lupin, the allergenic potential of different lupin species , sensitization patterns among different populations. Objective: To evaluate the molecular basis of LA and to determine lupin allergens from 3 different species that may be involved in peanut allergy (PA) cross-reactivity.Methods: A total of 43 subjects with PA, those with LA, or controls without food allergy were evaluated with skin prick tests (SPTs) and specific IgEs (sIgEs). Lupin-sensitized subjects were offered a lupin oral food challenge (OFC). Immunoblots and enzyme-linked immunosorbent assays were performed on sera from lupin-sensitized subjects.Results: In this study, 44% of the PA subjects were confirmed to have LA by OFC. Anaphylaxis was the most fre-quent manifestation after lupin consumption, with a minimal eliciting dosage of 1 g lupin flour. There was no dif-ference in lupin sIgE or SPT wheal size between lupin-sensitized and confirmed LA subjects or in the severity of symptoms among confirmed LA subjects. Sera from lupin-sensitized subjects uniformly reacted to all 3 different lupin species. Immunoblotting and enzyme-linked immunosorbent assays revealed immunoglobulin E binding to a- and-y-conglutin in all analyzed sera, whereas a- and 0-conglutin recognition was variable.Conclusion: Our findings reveal a high prevalence of LA among PA subjects, emphasizing lupin must be labeled as an allergen in foods. Owing to high variability in lupin-sIgE and lupin-SPT results, LA diagnosis may require OFC. In our population,-y-conglutin is the major allergen of lupin.(c) 2022 American College of Allergy, Asthma , Immunology. Published by Elsevier Inc. All rights reserved.
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| Fecha Publicación |
2023
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| Tipo de Recurso |
artículo original
|
| doi |
10.1016/j.anai.2022.09.036
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| Formato Recurso |
PDF
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| Palabras Claves |
Allergens
Arachis
Food Hypersensitivity
Humans
Immunoglobulin E
Lupinus / adverse effects
Peanut Hypersensitivity / diagnosis
Peanut Hypersensitivity / epidemiology
Prevalence
Skin Tests / methods
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| Ubicación del archivo | |
| Categoría OCDE |
Alergia
Inmunología
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| Materias |
Alérgenos
Arachis
Hipersensibilidad Alimentaria
Humanos
Inmunoglobulina E
Lupinus / efectos adversos
Hipersensibilidad al maní / diagnóstico
Hipersensibilidad al maní / epidemiología
Predominio
Pruebas/métodos cutáneos
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| Página de inicio (Recomendado-único) |
225.0
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| Página final (Recomendado-único) |
232
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| Identificador del recurso (Mandatado-único) |
artículo original
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| Versión del recurso (Recomendado-único) |
versión publicada
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| Derechos de acceso |
metadata
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| Access Rights |
metadata
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| Id de Web of Science |
WOS:000992401900001
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| ISSN |
1081-1206
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| Categoría WOS |
Alergia
Inmunología
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID-FONDECYT 11160283
ANID-FONDECYT 11161102
ANID FONDECYT 11160283
ANID FONDECYT 11161102
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