Repositorio
Institucional

Dehghan, Mahshid

Mente, Andrew

Rangarajan, Sumathy

Mohan, Viswanathan

Swaminathan, Sumathi

Avezum, Alvaro

Lear, Scott A.

Rosengren, Annika

Poirier, Paul

Lanas, Fernando

Lopez-Jaramillo, Patricio

Soman, Biju

Wang, Chuangshi

Orlandini, Andres

Mohammadifard, Noushin

AlHabib, Khalid F.

Chifamba, Jephat

Yusufali, Afzal Hussein

Iqbal, Romaina

Khatib, Rasha

Yeates, Karen

Puoane, Thandi

Altuntas, Yuksel

Co, Homer Uy

Li, Sidong

Liu, Weida

Zatonska, Katarzyna

Yusuf, Rita

Ismail, Noorhassim

Miller, Victoria

Yusuf, Salim

Ultra-processed foods and mortality: analysis from the Prospective Urban and Rural Epidemiology study

ELSEVIER SCIENCE INC

AMERICAN JOURNAL OF CLINICAL NUTRITION

en

Background: Higher intake of ultra-processed foods (UPFs) has been associated with increased risk of CVD and mortality in observational studies from Western countries but data from non-Western countries are limited. Objectives: We aimed to assess the association between consumption of UPFs and risk of mortality and major CVD in a cohort from multiple world regions. Design: This analysis includes 138,076 participants without a history of CVD between the ages of 35 and 70 y living on 5 continents, with a median follow-up of 10.2 y. We used country-specific validated food-frequency questionnaires to determine individuals' food intake. We classified foods and beverages based on the NOVA classification into UPFs. The primary outcome was total mortality (CV and non-CV mortality) and secondary outcomes were incident major cardiovascular events. We calculated hazard ratios using multivariable Cox frailty models and evaluated the association of UPFs with total mortality, CV mortality, non-CV mortality, and major CVD events. Results: In this study, 9227 deaths and 7934 major cardiovascular events were recorded during the follow-up period. We found a diet high in UPFs (>= 2 servings/d compared with 0 intake) was associated with higher risk of mortality (HR: 1.28, 95% CI: 1.15, 1.42, P-trend < 0.001), CV mortality (HR:1.17, 95% CI: 0.98, 1.41, P-trend = 0.04), and non-CV mortality (HR: 1.32, 95% CI 1.17, 1.50, P-trend < 0.001). We did not find a significant as-sociation between UPF intake and risk of major CVD. Conclusions: A diet with a high intake of UPFs was associated with a higher risk of mortality in a diverse multinational study. Globally, limiting the consumption of UPFs should be encouraged.

2023

artículo original

10.1016/j.ajcnut.2022.10.014

PDF

major cardiovascular disease

minimally processed foods

mortality

NOVA classification

ultra-processed foods

Nutrición y Dietética

enfermedad cardiovascular importante

alimentos mínimamente procesados

mortalidad

clasificación NOVA

alimentos ultraprocesados

versión publicada

hibrida

verde

acceso abierto

acceso abierto

WOS:000966252300001

55.0

63

artículo original

0002-9165

Nutrición y Dietética