Repositorio
Institucional

Uquiche, Edgar

Aviles, Jorge

Marillan, Claudia

Quevedo-Leon, Roberto

Three-stage sequential supercritical extraction in fixed bed extractor to obtain bioactive compounds from Leptocarpha rivularis leaves

ELSEVIER

JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS

en

This work studied sequential supercritical extraction to obtain extracts from L. rivularis leaves. Extraction assays were carried out in three stages at 40 or 70?, with stage 1: 20 MPa with CO2, stage 2: 40 MPa with CO2, and stage 3: 40 MPa with ethanol-modified CO2 (5% wt.). The total extraction yield was higher at 70 ? (41.77 g/kg d.s.) than at 40?(32.57 g/kg d.s.). The total content of terpenes and flavonoids and the ability of the extracts to inhibit the a-amylase and a-glucosidase enzymes were measured. At 40 C the stage 1 extract had a greater inhibition effect on a-glucosidase and the stage 2 extract a greater inhibition effect on a-amylase. Sequential supercritical extraction was properly modeled using a diffusion model based on Fick's second law, and an effective diffusion coefficient was determined for each stage. Sequential supercritical extraction can be a method to increase the extraction of bioactive compounds.

2023

artículo original

10.1016/j.jarmap.2023.100460

PDF

Supercritical extraction

Leptocarpha rivularis

Sequential extraction

alpha-amylase

alpha-glucosidase

Diffusion model

Ciencias de las plantas

Extracción supercrítica

Leptocarpha rivularis

Extracción secuencial

alfa-amilasa

alfa-glucosidasa

Modelo de difusión

artículo original

versión publicada

metadata

metadata

WOS:000995584200001

hibrida

Ciencias de las plantas

ANID-FONDECYT 1170841

ANID 22182141

ANID 21201441

ANID FONDECYT 1170841