Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness

Primer Autor
Marzuca-Nassr, Gabriel Nasri
Co-autores
Silva-Gutierrez, Alexis
Artigas-Arias, Macarena
Alegria-Molina, Andrea
Guerra-Vega, Pablo
Navarrete, Pablo
Venegas, Angela
Montecinos, Carlos
Vasquez, Lorena
Moraga, Karen
Rubilar, Cesar
Villagran, German
Parada, Rodrigo
Vitzel, Kaio Fernando
Título
Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness
Editorial
FRONTIERS MEDIA SA
Revista
FRONTIERS IN PHYSIOLOGY
Lenguaje
en
Resumen
Objective: Quantify and categorize by sex, age, and time spent on mechanical ventilation (MV), the decline in skeletal muscle mass, strength and mobility in critically ill patients infected with SARS-CoV-2 and requiring mechanical ventilation while at intensive care unit (ICU).Design: Prospective observational study including participants recruited between June 2020 and February 2021 at Hospital Clinico Herminda Martin (HCHM), Chillan, Chile. The thickness of the quadriceps muscle was evaluated by ultrasonography (US) at intensive care unit admission and awakening. Muscle strength and mobility were assessed, respectively, through the Medical Research Council Sum Score (MRC-SS) and the Functional Status Score for the Intensive Care Unit Scale (FSS-ICU) both at awakening and at ICU discharge. Results were categorized by sex (female or male), age (< 60 years old or & GE,60 years old) and time spent on MV (& LE,10 days or > 10 days).Setting: Intensive care unit in a public hospital.Participants: 132 participants aged 18 years old or above (women n = 49, 60 & PLUSMN, 13 years, men n = 85, 59 & PLUSMN, 12 years) admitted to intensive care unit with a confirmed diagnosis of severe SARS-CoV-2 and requiring MV for more than 48 h were included in the study. Patients with previous physical and or cognitive disorders were excluded.Interventions: Not applicable.Results: Muscle thickness have significantly decreased during intensive care unit stay, vastus intermedius (-11%, p = 0.025), rectus femoris (-20%, p < 0.001) and total quadriceps (-16%, p < 0.001). Muscle strength and mobility were improved at intensive care unit discharge when compared with measurements at awakening in intensive care unit (time effect, p < 0.001). Patients & GE,60 years old or on MV for > 10 days presented greater muscle loss, alongside with lower muscle strength and mobility.Conclusion: Critically ill patients infected with SARS-CoV-2 and requiring MV presented decreased muscle mass, strength, and mobility during their intensive care unit stay. Factors associated with muscle mass, such as age > 60 years and > 10 days of MV, exacerbated the critical condition and impaired recovery.
Fecha Publicación
2023
Tipo de Recurso
artículo original
doi
10.3389/fphys.2023.1095228
Formato Recurso
PDF
Palabras Claves
COVID-19
muscle weakness
critical care
muscular atrophy
functional status
Ubicación del archivo
Categoría OCDE
Fisiología
Materias
COVID-19
debilidad muscular
Cuidado crítico
atrofia muscular
estado funcional
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
versión publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000937841700001
Tipo de ruta
verde# dorado
Categoría WOS
Fisiología
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID-FONDECYT 11180949
UFRO DFP20-0034
UFRO DI21-0076
ANID FONDECYT 11180949
Universidad de La Frontera (UFRO) DFP20-0034
Universidad de La Frontera (UFRO) DI21-0076
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