Repositorio
Institucional

Marzuca-Nassr, Gabriel Nasri

Silva-Gutierrez, Alexis

Artigas-Arias, Macarena

Alegria-Molina, Andrea

Guerra-Vega, Pablo

Navarrete, Pablo

Venegas, Angela

Montecinos, Carlos

Vasquez, Lorena

Moraga, Karen

Rubilar, Cesar

Villagran, German

Parada, Rodrigo

Vitzel, Kaio Fernando

Characterization of muscle mass, strength and mobility of critically ill patients with SARS-CoV-2 pneumonia: Distribution by sex, age, days on mechanical ventilation, and muscle weakness

FRONTIERS MEDIA SA

FRONTIERS IN PHYSIOLOGY

en

Objective: Quantify and categorize by sex, age, and time spent on mechanical ventilation (MV), the decline in skeletal muscle mass, strength and mobility in critically ill patients infected with SARS-CoV-2 and requiring mechanical ventilation while at intensive care unit (ICU).Design: Prospective observational study including participants recruited between June 2020 and February 2021 at Hospital Clinico Herminda Martin (HCHM), Chillan, Chile. The thickness of the quadriceps muscle was evaluated by ultrasonography (US) at intensive care unit admission and awakening. Muscle strength and mobility were assessed, respectively, through the Medical Research Council Sum Score (MRC-SS) and the Functional Status Score for the Intensive Care Unit Scale (FSS-ICU) both at awakening and at ICU discharge. Results were categorized by sex (female or male), age (< 60 years old or & GE,60 years old) and time spent on MV (& LE,10 days or > 10 days).Setting: Intensive care unit in a public hospital.Participants: 132 participants aged 18 years old or above (women n = 49, 60 & PLUSMN, 13 years, men n = 85, 59 & PLUSMN, 12 years) admitted to intensive care unit with a confirmed diagnosis of severe SARS-CoV-2 and requiring MV for more than 48 h were included in the study. Patients with previous physical and or cognitive disorders were excluded.Interventions: Not applicable.Results: Muscle thickness have significantly decreased during intensive care unit stay, vastus intermedius (-11%, p = 0.025), rectus femoris (-20%, p < 0.001) and total quadriceps (-16%, p < 0.001). Muscle strength and mobility were improved at intensive care unit discharge when compared with measurements at awakening in intensive care unit (time effect, p < 0.001). Patients & GE,60 years old or on MV for > 10 days presented greater muscle loss, alongside with lower muscle strength and mobility.Conclusion: Critically ill patients infected with SARS-CoV-2 and requiring MV presented decreased muscle mass, strength, and mobility during their intensive care unit stay. Factors associated with muscle mass, such as age > 60 years and > 10 days of MV, exacerbated the critical condition and impaired recovery.

2023

artículo original

10.3389/fphys.2023.1095228

PDF

COVID-19

muscle weakness

critical care

muscular atrophy

functional status

Fisiología

COVID-19

debilidad muscular

Cuidado crítico

atrofia muscular

estado funcional

artículo original

versión publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

WOS:000937841700001

verde# dorado

Fisiología

ANID-FONDECYT 11180949

UFRO DFP20-0034

UFRO DI21-0076

ANID FONDECYT 11180949

Universidad de La Frontera (UFRO) DFP20-0034

Universidad de La Frontera (UFRO) DI21-0076