Safety Profile of Homologous and Heterologous Booster COVID-19 Vaccines in Physicians in Quito-Ecuador: A Cross-Sectional Study
| Primer Autor |
Rivadeneira-Duenas, Josue
|
| Co-autores |
Flores-Lastra, Nancy
Fuenmayor-Gonzalez, Luis
Guayasamin-Tipanta, Glenda
Jacome-Garcia, Michelle
Otzen, Tamara
Manterola, Carlos
|
| Título |
Safety Profile of Homologous and Heterologous Booster COVID-19 Vaccines in Physicians in Quito-Ecuador: A Cross-Sectional Study
|
| Editorial |
MDPI
|
| Revista |
VACCINES
|
| Lenguaje |
en
|
| Resumen |
More than 600 healthcare workers died due to COVID-19 infection until January 2022 in Ecuador. Even though the COVID-19 vaccines are safe, local and systemic reactions were reported among physicians. This study aims to analyze the adverse events of COVID-19 with an emphasis on comparing the homologous and heterologous booster doses in physicians that received three approved vaccines in Ecuador. An electronic survey was performed in Quito, Ecuador, directed at physicians who were vaccinated with the three doses of COVID-19 vaccines. A total of 210 participants were analyzed after administering any dose of the vaccines. At least one AE was identified in 60.0% (126/210) of the sample after the first dose, 52.40% (110/210) after the second dose, and 75.2% (158/210) after the booster dose. The most frequent AEs were localized pain, myalgia, headache, and fever. At least one drug was used in 44.3% of the population after the first dose, 37.1% after the second dose, and 63.8% in the booster dose. Heterologous booster produces more AEs compared with homologous booster (80.1% vs. 53.8%), and 77.3% of participants reported that interfered with daily activities. Similar studies agree that reactogenicity occurs mainly with heterologous vaccination compared to homologous vaccination. This situation affected physicians' performance in daily activities and led them to use medication for the symptoms. In the future, it is recommended to perform cohort studies, where adverse events that are associated with vaccine boosters in the general population can be analyzed longitudinally, thus improving the level of evidence of the results.
|
| Fecha Publicación |
2023
|
| Tipo de Recurso |
artículo original
|
| doi |
10.3390/vaccines11030676
|
| Formato Recurso |
PDF
|
| Palabras Claves |
COVID-19 vaccines
BNT162 vaccine
ChAdOx1 nCoV-19
side effects and adverse reactions
booster immunizations
COVID-19
SARS-CoV-2
|
| Ubicación del archivo | |
| Categoría OCDE |
Inmunología
Investigación y Medicina Experimental
|
| Materias |
Vacunas para COVID-19
vacuna BNT162
ChAdOx1 nCoV-19
efectos secundarios y reacciones adversas
vacunas de refuerzo
COVID-19
SARS-CoV-2
|
| Identificador del recurso (Mandatado-único) |
artículo original
|
| Versión del recurso (Recomendado-único) |
versión publicada
|
| License |
CC BY 4.0
|
| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
|
| Access Rights |
acceso abierto
|
| Id de Web of Science |
WOS:000968342500001
|
| Tipo de ruta |
verde# dorado
|
| Categoría WOS |
Inmunología
Investigación y Medicina Experimental
|
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