Extraction of bioactive compounds from Leptocarpha rivularis stems by three-stage sequential supercritical extraction in fixed bed extractor using CO2 and ethanol-modified CO2

Primer Autor
Uquiche, Edgar
Co-autores
Marillan, Claudia
Título
Extraction of bioactive compounds from Leptocarpha rivularis stems by three-stage sequential supercritical extraction in fixed bed extractor using CO2 and ethanol-modified CO2
Editorial
ELSEVIER
Revista
JOURNAL OF SUPERCRITICAL FLUIDS
Lenguaje
en
Resumen
Sequential supercritical extraction experiments were carried out in three stages each using CO2 and ethanol-modified-CO2, to improve the extraction yield of bioactive compounds from L. rivularis stems. Four experiments were carried out, each in three stages, combining different levels of temperature (40 or 60 degrees C) and pressure (20-50 MPa). The increase in pressure and use of a cosolvent increased the total yield of extract and target compounds compared to one-stage extraction. The highest extraction yields of extract (6.29 g/kg d.s.), terpenes (699.9 mg/kg d.s.), flavonoids (741.9 mg/kg d.s.), and alkaloids (6.22 mg/kg d.s.) were obtained in Experiment 4. Sequential extraction of compounds was superior to one-stage extraction using CO2, but inferior when using ethanol-modified CO2. Both sequential and one-stage cumulative extraction curves were modeled, and the effective diffusivity coefficients ranged between 1.51 and 63.3 x 10-13 m2/s, being highest in Stage 3 where the extraction yield was greatest.
Fecha Publicación
2023
Tipo de Recurso
artículo original
doi
10.1016/j.supflu.2023.105903
Formato Recurso
PDF
Palabras Claves
Sequential supercritical extraction
Fixed bed extractor
Diffusion model
Bioactive compounds
Ethanol cosolvent
Ubicación del archivo
http://dx.doi.org/10.1016/j.supflu.2023.105903
Categoría OCDE
Ingeniería química
Materias
Extracción supercrítica secuencial
Extractor de cama fija
Modelo de difusión
Compuestos bioactivos
Cosolvente de etanol
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
versión publicada
Derechos de acceso
metadata
Access Rights
metadata
Id de Web of Science
WOS:000955304200001
ISSN
0896-8446
Categoría WOS
Ingeniería química
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID-FONDECYT 21201441
ANID-FONDECYT 1170841
UFRO DI21-0107
Universidad de La Frontera (UFRO) DI21-0107
Colecciones
Colección Publicaciones Científicas
Colección ANID
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