Repositorio UFRO · Omeka S

Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma

Primer Autor	Riquelme, Ismael
Co-autores	Perez-Moreno, Pablo Mora-Lagos, Barbara Ili, Carmen Brebi, Priscilla Roa, Juan Carlos
Título	Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma
Editorial	MDPI
Revista	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje	en
Resumen	Gastric cancer (GC) represents similar to 10% of the global cancer-related deaths, increasingly affecting the younger population in active stages of life. The high mortality of GC is due to late diagnosis, the presence of metastasis and drug resistance development. Additionally, current clinical markers do not guide the patient management adequately, thereby new and more reliable biomarkers and therapeutic targets are still needed for this disease. RNA-seq technology has allowed the discovery of new types of RNA transcripts including long non-coding RNAs (lncRNAs), which are able to regulate the gene/protein expression of many signaling pathways (e.g., the PI3K/AKT/mTOR pathway) in cancer cells by diverse molecular mechanisms. In addition, these lncRNAs might also be proposed as promising diagnostic or prognostic biomarkers or as potential therapeutic targets in GC. This review describes important topics about some lncRNAs that have been described as regulators of the PI3K/AKT/mTOR signaling pathway, and hence, their potential oncogenic role in the development of this malignancy.
Fecha Publicación	2023
Tipo de Recurso	artículo de revisión
doi	10.3390/ijms24076294
Formato Recurso	PDF
Palabras Claves	gastric cancer (GC) long non-coding RNAs (lncRNAs) PI3K/AKT/mTOR signaling pathway
Ubicación del archivo	http://dx.doi.org/10.3390/ijms24076294
Categoría OCDE	Bioquímica y biología molecular Química
Materias	cáncer gástrico (CG) ARN largos no codificantes (lncRNA) Vía de señalización PI3K/AKT/mTOR
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000969968300001
ISSN	1661-6596
Tipo de ruta	verde# dorado
Categoría WOS	Bioquímica y biología molecular Química
Referencia del Financiador (Mandatado si es aplicable-repetible)	ANID-FONDECYT 3210237 ANID-FONDECYT 3210629 ANID-FONDECYT 1210440 ANID-FONDECYT 1221345 UA 03-2022 UFRO DI20-0128 UFRO DI20-0160 ANID-FONDEF ID21I10027 IMII ICN2021_045 UE H2020 825510 ANID-FONDAP 152220002 ANID FONDECYT 3210237 ANID FONDECYT 3210629 ANID FONDECYT 1210440 ANID FONDECYT 1221345 ANID FONDEF ID21I10027 ERC H2020 825510 ANID FONDAP 152220002