Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma
| Primer Autor |
Riquelme, Ismael
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| Co-autores |
Perez-Moreno, Pablo
Mora-Lagos, Barbara
Ili, Carmen
Brebi, Priscilla
Roa, Juan Carlos
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| Título |
Long Non-Coding RNAs (lncRNAs) as Regulators of the PI3K/AKT/mTOR Pathway in Gastric Carcinoma
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| Editorial |
MDPI
|
| Revista |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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| Lenguaje |
en
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| Resumen |
Gastric cancer (GC) represents similar to 10% of the global cancer-related deaths, increasingly affecting the younger population in active stages of life. The high mortality of GC is due to late diagnosis, the presence of metastasis and drug resistance development. Additionally, current clinical markers do not guide the patient management adequately, thereby new and more reliable biomarkers and therapeutic targets are still needed for this disease. RNA-seq technology has allowed the discovery of new types of RNA transcripts including long non-coding RNAs (lncRNAs), which are able to regulate the gene/protein expression of many signaling pathways (e.g., the PI3K/AKT/mTOR pathway) in cancer cells by diverse molecular mechanisms. In addition, these lncRNAs might also be proposed as promising diagnostic or prognostic biomarkers or as potential therapeutic targets in GC. This review describes important topics about some lncRNAs that have been described as regulators of the PI3K/AKT/mTOR signaling pathway, and hence, their potential oncogenic role in the development of this malignancy.
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| Fecha Publicación |
2023
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| Tipo de Recurso |
artículo de revisión
|
| doi |
10.3390/ijms24076294
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| Formato Recurso |
PDF
|
| Palabras Claves |
gastric cancer (GC)
long non-coding RNAs (lncRNAs)
PI3K/AKT/mTOR signaling pathway
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| Ubicación del archivo | |
| Categoría OCDE |
Bioquímica y biología molecular
Química
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| Materias |
cáncer gástrico (CG)
ARN largos no codificantes (lncRNA)
Vía de señalización PI3K/AKT/mTOR
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| Identificador del recurso (Mandatado-único) |
artículo de revisión
|
| Versión del recurso (Recomendado-único) |
versión publicada
|
| License |
CC BY 4.0
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| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
|
| Access Rights |
acceso abierto
|
| Id de Web of Science |
WOS:000969968300001
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| ISSN |
1661-6596
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| Tipo de ruta |
verde# dorado
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| Categoría WOS |
Bioquímica y biología molecular
Química
|
| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID-FONDECYT 3210237
ANID-FONDECYT 3210629
ANID-FONDECYT 1210440
ANID-FONDECYT 1221345
UA 03-2022
UFRO DI20-0128
UFRO DI20-0160
ANID-FONDEF ID21I10027
IMII ICN2021_045
UE H2020 825510
ANID-FONDAP 152220002
ANID FONDECYT 3210237
ANID FONDECYT 3210629
ANID FONDECYT 1210440
ANID FONDECYT 1221345
ANID FONDEF ID21I10027
ERC H2020 825510
ANID FONDAP 152220002
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