l-Asparaginase as the gold standard in the treatment of acute lymphoblastic leukemia: a comprehensive review

Primer Autor
Farias, Jorge G.
Co-autores
Tosta Perez, Maria
Herrera Belen, Lisandra
Letelier, Pablo
Calle, Yolanda
Pessoa, Adalberto
Título
l-Asparaginase as the gold standard in the treatment of acute lymphoblastic leukemia: a comprehensive review
Editorial
HUMANA PRESS INC
Revista
MEDICAL ONCOLOGY
Lenguaje
en
Resumen
l-Asparaginase is an antileukemic drug long approved for clinical use to treat childhood acute lymphoblastic leukemia, the most common cancer in this population worldwide. However, the efficacy and its use as a drug have been subject to debate due to the variety of adverse effects that patients treated with it present, as well as the prompt elimination in plasma, the need for multiple administrations, and high rates of allergic reactions. For this reason, the search for new, less immunogenic variants has long been the subject of study. This review presents the main aspects of the l-asparaginase enzyme from a structural, pharmacological, and clinical point of view, from the perspective of its use in chemotherapy protocols in conjunction with other drugs in the different treatment phases.
Fecha Publicación
2023
Tipo de Recurso
artículo de revisión
doi
10.1007/s12032-023-02014-9
Formato Recurso
PDF
Palabras Claves
Acute lymphoblastic leukemia
Asparaginase
Antineoplastic agent
Immunogenicity
Hypersensitivity
Ubicación del archivo
http://dx.doi.org/10.1007/s12032-023-02014-9
Categoría OCDE
Oncología
Materias
Leucemia linfoblástica aguda
asparaginasa
Agente antineoplásico
Inmunogenicidad
Hipersensibilidad
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
versión publicada
Derechos de acceso
restringido
Access Rights
restringido
Id de Web of Science
WOS:000969750300002
ISSN
1357-0560
Tipo de ruta
verde / dorado
Categoría WOS
Oncología
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID 21210710
CNPQ 301832/2017-0
Colecciones
Colección Publicaciones Científicas
Colección ANID
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