Clinical and histopathological features of follicular thyroid cancer in Chile

Primer Autor
Sapunar, Jorge
Co-autores
Diaz, Rene
Dominguez, Jose Miguel
Tala, Hernan
Olmos, Roberto
Pineda, Pedro
Olivari, Daniela
Jimenez, Marcela
Mimica, Ximena
Lanas, Alejandra
Ocares, Gerson
Título
Clinical and histopathological features of follicular thyroid cancer in Chile
Editorial
SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
Revista
ARCHIVES OF ENDOCRINOLOGY METABOLISM
Lenguaje
en
Resumen
Objective: Follicular thyroid carcinoma (FTC) is less frequent but has a worse prognosis than papillary carcinoma. The available evidence on pre-operative characteristics of FTC is controversial. Our objective was to characterize the clinical, ultrasound and histopathological presentation of FTC patients treated Chile. Subjects and methods: Retrospective analysis of 97 patients treated for FTC in 6 large centers in Chile. We analyzed their ultrasonographic features and classified the nodules according to ATA risk of malignancy and TI-RADS score, as well as the cytological findings according to the Bethesda system. We described their clinical and histopathological findings at diagnosis and classified their risk of recurrence and mortality according to ATA 2015 recurrence risk category and the eighth edition of the AJCC/UICC staging system, respectively. Results: Median age was 48 years and 73.2% were females. The median diameter was 38.8 mm, only 9.5% of them were microtumors. According to ATA risk of malignancy, 86% of the nodules were low or intermediate suspicious, while 78% were category 3 or 4A nodules according to the TI-RADS. Regarding the Bethesda system, 65.9% had indeterminate cytology (20.6% category III and 45.3% category IV). At histological examination, most were minimally-invasive and angio-invasive tumors with less than 4 foci (54.7% and 28.4% respectively). More than 90% of FTC were unifocal and there was no lymphovascular or extrathyroidal invasion or lymph node involvement. Four patients (4.1%) had distant metastases at diagnosis. Most patients (95%) had stage I or II disease according to the AJCC/UICC staging system, while the risk of recurrence was low at 51.5% when using the ATA risk of recurrence scale. Conclusions: At diagnosis, most FTCs were nodules of low or intermediate suspicion at ultrasound, nearly two thirds had indeterminate cytology according to the Bethesda system, and nearly 50% of them were of low risk of recurrence.
Fecha Publicación
2023
Tipo de Recurso
artículo original
doi
10.20945/2359-3997000000580
Formato Recurso
PDF
Palabras Claves
Thyroid cancer
follicular
diagnosis
prognosis
Ubicación del archivo
Categoría OCDE
Endocrinología y Metabolismo
Materias
Cáncer de tiroides
folicular
diagnóstico
pronóstico
Página de inicio (Recomendado-único)
348.0
Página final (Recomendado-único)
354
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
versión publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:000973573400008
ISSN
2359-3997
Tipo de ruta
verde# dorado
Categoría WOS
Endocrinología y Metabolismo
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