Repositorio UFRO · Omeka S

Clinical and histopathological features of follicular thyroid cancer in Chile

Primer Autor	Sapunar, Jorge
Co-autores	Diaz, Rene Dominguez, Jose Miguel Tala, Hernan Olmos, Roberto Pineda, Pedro Olivari, Daniela Jimenez, Marcela Mimica, Ximena Lanas, Alejandra Ocares, Gerson
Título	Clinical and histopathological features of follicular thyroid cancer in Chile
Editorial	SBEM-SOC BRASIL ENDOCRINOLOGIA & METABOLOGIA
Revista	ARCHIVES OF ENDOCRINOLOGY METABOLISM
Lenguaje	en
Resumen	Objective: Follicular thyroid carcinoma (FTC) is less frequent but has a worse prognosis than papillary carcinoma. The available evidence on pre-operative characteristics of FTC is controversial. Our objective was to characterize the clinical, ultrasound and histopathological presentation of FTC patients treated Chile. Subjects and methods: Retrospective analysis of 97 patients treated for FTC in 6 large centers in Chile. We analyzed their ultrasonographic features and classified the nodules according to ATA risk of malignancy and TI-RADS score, as well as the cytological findings according to the Bethesda system. We described their clinical and histopathological findings at diagnosis and classified their risk of recurrence and mortality according to ATA 2015 recurrence risk category and the eighth edition of the AJCC/UICC staging system, respectively. Results: Median age was 48 years and 73.2% were females. The median diameter was 38.8 mm, only 9.5% of them were microtumors. According to ATA risk of malignancy, 86% of the nodules were low or intermediate suspicious, while 78% were category 3 or 4A nodules according to the TI-RADS. Regarding the Bethesda system, 65.9% had indeterminate cytology (20.6% category III and 45.3% category IV). At histological examination, most were minimally-invasive and angio-invasive tumors with less than 4 foci (54.7% and 28.4% respectively). More than 90% of FTC were unifocal and there was no lymphovascular or extrathyroidal invasion or lymph node involvement. Four patients (4.1%) had distant metastases at diagnosis. Most patients (95%) had stage I or II disease according to the AJCC/UICC staging system, while the risk of recurrence was low at 51.5% when using the ATA risk of recurrence scale. Conclusions: At diagnosis, most FTCs were nodules of low or intermediate suspicion at ultrasound, nearly two thirds had indeterminate cytology according to the Bethesda system, and nearly 50% of them were of low risk of recurrence.
Fecha Publicación	2023
Tipo de Recurso	artículo original
doi	10.20945/2359-3997000000580
Formato Recurso	PDF
Palabras Claves	Thyroid cancer follicular diagnosis prognosis
Ubicación del archivo	http://dx.doi.org/10.20945/2359-3997000000580
Categoría OCDE	Endocrinología y Metabolismo
Materias	Cáncer de tiroides folicular diagnóstico pronóstico
Página de inicio (Recomendado-único)	348.0
Página final (Recomendado-único)	354
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000973573400008
ISSN	2359-3997
Tipo de ruta	verde# dorado
Categoría WOS	Endocrinología y Metabolismo