Repositorio UFRO · Omeka S

Potential of Oral Cavity Stem Cells for Bone Regeneration: A Scoping Review

Primer Autor	Fuentes, Ramon
Co-autores	Alarcon-Apablaza, Josefa Prieto, Ruth Rojas, Mariana
Título	Potential of Oral Cavity Stem Cells for Bone Regeneration: A Scoping Review
Editorial	MDPI
Revista	CELLS
Lenguaje	en
Resumen	Bone loss is a common problem that ranges from small defects to large defects after trauma, surgery, or congenital malformations. The oral cavity is a rich source of mesenchymal stromal cells (MSCs). Researchers have documented their isolation and studied their osteogenic potential. Therefore, the objective of this review was to analyze and compare the potential of MSCs from the oral cavity for use in bone regeneration. Methods: A scoping review was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. The databases reviewed were PubMed, SCOPUS, Scientific Electronic Library Online (SciELO), and Web of Science. Studies using stem cells from the oral cavity to promote bone regeneration were included. Results: A total of 726 studies were found, of which 27 were selected. The MSCs used to repair bone defects were (I) dental pulp stem cells of permanent teeth, (II) stem cells derived from inflamed dental pulp, (III) stem cells from exfoliated deciduous teeth, (IV) periodontal ligament stem cells, (V) cultured autogenous periosteal cells, (VI) buccal fat pad-derived cells, and (VII) autologous bone-derived mesenchymal stem cells. Stem cells associate with scaffolds to facilitate insertion into the bone defect and to enhance bone regeneration. The biological risk and morbidity of the MSC-grafted site were minimal. Successful bone formation after MSC grafting has been shown for small defects with stem cells from the periodontal ligament and dental pulp as well as larger defects with stem cells from the periosteum, bone, and buccal fat pad. Conclusions: Stem cells of maxillofacial origin are a promising alternative to treat small and large craniofacial bone defects, however, an additional scaffold complement is required for stem cell delivery.
Fecha Publicación	2023
Tipo de Recurso	artículo de revisión
doi	10.3390/cells12101392
Formato Recurso	PDF
Palabras Claves	stem cells stomatognathic system tissue engineering bone regeneration
Ubicación del archivo	http://dx.doi.org/10.3390/cells12101392
Categoría OCDE	Biología Celular
Materias	Células madre sistema estomatognático Ingeniería de tejidos regeneración ósea
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:000996540400001
Tipo de ruta	verde# dorado
Categoría WOS	Biología Celular