Evaluation of trefoil factor 3 as a non-invasive biomarker of gastric intestinal metaplasia and gastric cancer in a high-risk population
| Primer Autor |
Riquelme, Arnoldo
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| Co-autores |
Latorre, Gonzalo
Pizarro, Margarita
Ford, James Stephen
Gandara, Vicente
Munoz, Gonzalo
Araya, Juan Carlos
Bellolio, Enrique
Villaseca, Miguel
Fuentes-Lopez, Eduardo
Cortes, Pablo
Rollan, Antonio
Bufadel, Maria Ester
Araya, Raul
Vargas, Jose Ignacio
Espino, Alberto
Sharp, Allan
Aguero, Carlos
Donoso, Andres
Bresky, Gustavo
Pedrero, Pamela
Rueda, Carlos
Calvo, Alfonso
Odagaki, Tomoyuki
Moriyama, Tomohiko
Ishida, Tsukasa
Parra-Blanco, Adolfo
Camargo, M. Constanza
Gonzalez, Robinson
Corvalan, Alejandro H.
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| Título |
Evaluation of trefoil factor 3 as a non-invasive biomarker of gastric intestinal metaplasia and gastric cancer in a high-risk population
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| Editorial |
ELSEVIER ESPANA SLU
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| Revista |
GASTROENTEROLOGIA Y HEPATOLOGIA
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| Lenguaje |
en
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| Resumen |
Background: Adenocarcinoma is preceded by chronic atrophic gastritis, gastric intestinal meta-plasia and dysplasia. Trefoil factor 3 (TFF3) is a peptide secreted by goblet cells, which is abundantly present in intestinal metaplasia. Aim: To evaluate the utility of serum TFF3 as a non-invasive biomarker for the diagnosis of intestinal metaplasia and gastric cancer. Methods: Single-center, cross-sectional study of 274 patients who consecutively underwent upper gastrointestinal endoscopy with gastric biopsies (updated Sydney system). TFF3 levels were measured in serum by a commercial ELISA kit. Patients with normal histology or chronic atrophic gastritis without intestinal metaplasia comprised the control group. In addition, 14 patients with invasive gastric cancer were included as a reference group. The association between TFF3 levels and intestinal metaplasia was assessed by logistic regression. Results: Patients with intestinal metaplasia (n = 110) had a higher median TFF3 level as com-pared to controls (n = 164), 13.1 vs. 11.9 ng/mL, respectively (p = 0.024). Multivariable logistic regression showed a no significant association between TFF3 levels and intestinal metaplasia (OR = 1.20, 95%CI: 0.87-1.65, p-trend = 0.273). The gastric cancer group had a median TFF3 level of 20.5 ng/mL, and a significant association was found (OR = 3.26, 95%CI: 1.29-8.27, p-trend = 0.013). Conclusion: Serum levels of TFF3 do not discriminate intestinal metaplasia in this high-risk Latin American population. Nevertheless, we confirmed an association between TFF3 levels and invasive gastric cancer. (c) 2022 Elsevier Espan similar to a, S.L.U. All rights reserved.
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| Fecha Publicación |
2023
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| Tipo de Recurso |
artículo original
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| doi |
10.1016/j.gastrohep.2022.04.004
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| Formato Recurso |
PDF
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| Palabras Claves |
Trefoil factor 3
Gastric cancer
Precancerous conditions
Intestinal metaplasia
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| Ubicación del archivo | |
| Categoría OCDE |
Gastroenterología y Hepatología
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| Materias |
factor de trébol 3
Cáncer gástrico
Condiciones precancerosas
Metaplasia intestinal
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| Página de inicio (Recomendado-único) |
411.0
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| Página final (Recomendado-único) |
418
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| Identificador del recurso (Mandatado-único) |
artículo original
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| Versión del recurso (Recomendado-único) |
versión publicada
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| Derechos de acceso |
metadata
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| Access Rights |
metadata
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| Id de Web of Science |
WOS:001005226100001
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| ISSN |
0210-5705
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| Tipo de ruta |
hibrida
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| Categoría WOS |
Gastroenterología y Hepatología
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
CONICYT-FONDAP 15130011
ANID-FONDECYT 1151411
ANID CONICYT-FONDAP 15130011
ANID FONDECYT 1151411
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