Repositorio
Institucional

Aguirre, Pedro

Letelier, K.

Parra-Melipan, S.

Negrete-Vergara, C.

Lopez, V.

Valdebenito, G.

Artigas, V.

Aranda, B.

Vega, A.

Moya, S. A.

High activities of nickel (II) complexes containing phosphorus-nitrogen ligands in hydrogen transfer reaction of imines using formic acid as a renewable hydrogen source

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MOLECULAR CATALYSIS

en

The catalytic reduction of imines to obtain secondary amines is an important route in the synthesis of molecules of biological or pharmaceutical interest. A series of new nickel (II) complexes bearing phosphorous-nitrogen (P, N) or phosphorous-nitrogen-phosphorous (P,N,P) ligands were characterized and studied as catalysts in hydrogen transfer reaction of imines, using formic acid as a hydrogen source, while avoiding the use of molecular hydrogen (H2). The complexes, of general formula NiCl2(L), [Ni(L)2](CF3SO3)2 (in which L is a P,N ligand) and [NiCl(L)]Cl (in the case of a tridentate PNP ligand), were active catalysts in the imine hydrogen, with turnover frequencies (TOF) up to 373 h-1 with NiCl2L1 complex (L1 = 2-(diphenylphosphinoamino) pyridine) and Nbenzylideneaniline as substrate, while a [Ni(L)2](CF3SO3)2 complex bearing the same P,N ligand achieved a slightly lower activity (TOF = 320 h-1). Catalyst recyclability was also studied, achieving near full conversion after four cycles, with a total substrate/catalyst ratio of 1000:1.

2023

artículo original

10.1016/j.mcat.2023.113262

PDF

Phosphorous -nitrogen ligands

Nickel(II) catalysts

Imine hydrogenation

Formic acid as a hydrogen source

Química

Ligandos fósforo-nitrógeno

Catalizadores de níquel (II)

Hidrogenación de iminas

El ácido fórmico como fuente de hidrógeno.

artículo original

versión publicada

metadata

metadata

WOS:001013219500001

2468-8231

Química

UCH VID ENL 06/20

CNRS IRP 2022-2026

ANID-FONDECYT 3220321

ANID AFB220001

ANID FONDECYT 3220321