Co-Encapsulation of Curcumin and a-Tocopherol in Bicosome Systems: Physicochemical Properties and Biological Activity

Primer Autor
Vergara, Daniela
Co-autores
Lopez, Olga
Sanhueza, Claudia
Chavez-Aravena, Catalina
Villagra, Jose
Bustamante, Mariela
Acevedo, Francisca
Título
Co-Encapsulation of Curcumin and a-Tocopherol in Bicosome Systems: Physicochemical Properties and Biological Activity
Editorial
MDPI
Revista
PHARMACEUTICS
Lenguaje
en
Resumen
A novel co-encapsulation system called bicosomes (bicelles within liposomes) has been developed to overcome the limitations associated with the topical application of curcumin (cur) and a-tocopherol (a-toc). The physicochemical properties and biological activity in vitro of bicosome systems were evaluated. Bicelles were prepared with DPPC, DHPC, cur, and a-toc (cur/a-toc-bicelles). Liposomal vesicles loading cur/a-toc-bicelles were prepared with Lipoid P-100 and cholesterol-forming cur/a-toc-bicosomes. Three cur/a-toc-bicosomes were evaluated using different total lipid percent-ages (12, 16, and 20% w/v). The results indicated that formulations manage to solubilize cur and oc-toc in homogeneous bicelles < 20 nm, while the bicosomes reaches 303-420 nm depending on the total lipid percentage in the systems. Bicosomes demonstrated high-encapsulation efficiency (EE) for cur (56-77%) and a-toc (51-65%). The loading capacity (LC) for both antioxidant com-pounds was 52-67%. In addition, cur/a-toc-bicosomes decreased the lipid oxidation by 52% and increased the antioxidant activity by 60% compared to unloaded bicosomes. The cell viability of these cur/a-toc-bicosomes was >85% in fibroblasts (3T3L1/CL-173 (TM)) and =65% in keratinocytes (Ha-CaT) and proved to be hematologically compatible. The cur/a-toc-bicelles and cur/a-toc-bicosomes inhibited the growth of C. albicans in a range between 33 and 76%. Our results propose bicosome systems as a novel carrier able to co-encapsulate, solubilize, protect, and improve the delivery performance of antioxidant molecules. The relevance of these findings is based on the synergistic antioxidant effect of its components, its biocompatibility, and its efficacy for dermal tissue treatment damaged by oxidative stress or by the presence of C. albicans. However, further studies are needed to assess the efficacy and safety of cur/a-toc bicosomes in vitro and in vivo.
Fecha Publicación
2023
Tipo de Recurso
artículo original
doi
10.3390/pharmaceutics15071912
Formato Recurso
PDF
Palabras Claves
curcumin
& alpha
-tocopherol
bicosomes
delivery system
skin
oxidative stress
candidiasis
Ubicación del archivo
Categoría OCDE
Farmacología y farmacia
Materias
curcumina
?-tocoferol
bicosomas
sistema de entrega
piel
estrés oxidativo
candidiasis
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
versión publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:001039667000001
Tipo de ruta
verde# dorado
Categoría WOS
Farmacología y farmacia
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID-FONDECYT 3210533
ANID FONDECYT 3210533
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