Repositorio
Institucional

Paz, Cristian

Marin, Victor

Burgos, Viviana

Perez, Rebeca

Maria, Durvanei Augusto

Pardi, Paulo

The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment

MDPI

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

en

Breast cancer is one of the most diagnosed cancers worldwide, with an incidence of 47.8%. Its treatment includes surgery, radiotherapy, chemotherapy, and antibodies giving a mortality of 13.6%. Breast tumor development is driven by a variety of signaling pathways with high heterogeneity of surface receptors, which makes treatment difficult. Epigallocatechin-3-gallate (EGCG) is a natural polyphenol isolated as the main component in green tea, it has shown multiple beneficial effects in breast cancer, controlling proliferation, invasion, apoptosis, inflammation, and demethylation of DNA. These properties were proved in vitro and in vivo together with synergistic effects in combination with traditional chemotherapy, increasing the effectiveness of the treatment. This review focuses on the effects of EGCG on the functional capabilities acquired by breast tumor cells during its multistep development, the molecular and signal pathways involved, the synergistic effects in combination with current drugs, and how nanomaterials can improve its bioavailability on breast cancer treatment.

2023

artículo de revisión

10.3390/ijms241310737

PDF

epigallocatechin-3-gallate

breast cancer

synergistic chemotherapy

metabolism

drug delivery

Bioquímica y biología molecular

Química

epigalocatequina-3-galato

cáncer de mama

quimioterapia sinérgica

metabolismo

entrega de drogas

artículo de revisión

versión publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

WOS:001028186200001

1661-6596

verde# dorado

Bioquímica y biología molecular

Química