The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment

Primer Autor
Paz, Cristian
Co-autores
Marin, Victor
Burgos, Viviana
Perez, Rebeca
Maria, Durvanei Augusto
Pardi, Paulo
Título
The Potential Role of Epigallocatechin-3-Gallate (EGCG) in Breast Cancer Treatment
Editorial
MDPI
Revista
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje
en
Resumen
Breast cancer is one of the most diagnosed cancers worldwide, with an incidence of 47.8%. Its treatment includes surgery, radiotherapy, chemotherapy, and antibodies giving a mortality of 13.6%. Breast tumor development is driven by a variety of signaling pathways with high heterogeneity of surface receptors, which makes treatment difficult. Epigallocatechin-3-gallate (EGCG) is a natural polyphenol isolated as the main component in green tea, it has shown multiple beneficial effects in breast cancer, controlling proliferation, invasion, apoptosis, inflammation, and demethylation of DNA. These properties were proved in vitro and in vivo together with synergistic effects in combination with traditional chemotherapy, increasing the effectiveness of the treatment. This review focuses on the effects of EGCG on the functional capabilities acquired by breast tumor cells during its multistep development, the molecular and signal pathways involved, the synergistic effects in combination with current drugs, and how nanomaterials can improve its bioavailability on breast cancer treatment.
Fecha Publicación
2023
Tipo de Recurso
artículo de revisión
doi
10.3390/ijms241310737
Formato Recurso
PDF
Palabras Claves
epigallocatechin-3-gallate
breast cancer
synergistic chemotherapy
metabolism
drug delivery
Ubicación del archivo
http://dx.doi.org/10.3390/ijms241310737
Categoría OCDE
Bioquímica y biología molecular
Química
Materias
epigalocatequina-3-galato
cáncer de mama
quimioterapia sinérgica
metabolismo
entrega de drogas
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
versión publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:001028186200001
ISSN
1661-6596
Tipo de ruta
verde# dorado
Categoría WOS
Bioquímica y biología molecular
Química
Colecciones
Colección Publicaciones Científicas
Colección ANID
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