Repositorio UFRO · Omeka S

Therapeutic Targets of Monoclonal Antibodies Used in the Treatment of Cancer: Current and Emerging

Primer Autor	Effer, Brian
Co-autores	Perez, Isabela Ulloa, Daniel Mayer, Carolyn Munoz, Francisca Bustos, Diego Rojas, Claudio Manterola, Carlos Vergara-Gomez, Luis Dappolonnio, Camila Weber, Helga Leal, Pamela
Título	Therapeutic Targets of Monoclonal Antibodies Used in the Treatment of Cancer: Current and Emerging
Editorial	MDPI
Revista	BIOMEDICINES
Lenguaje	en
Resumen	Cancer is one of the leading global causes of death and disease, and treatment options are constantly evolving. In this sense, the use of monoclonal antibodies (mAbs) in immunotherapy has been considered a fundamental aspect of modern cancer therapy. In order to avoid collateral damage, it is indispensable to identify specific molecular targets or biomarkers of therapy and/or diagnosis (theragnostic) when designing an appropriate immunotherapeutic regimen for any type of cancer. Furthermore, it is important to understand the currently employed mAbs in immunotherapy and their mechanisms of action in combating cancer. To achieve this, a comprehensive understanding of the biology of cancer cell antigens, domains, and functions is necessary, including both those presently utilized and those emerging as potential targets for the design of new mAbs in cancer treatment. This review aims to provide a description of the therapeutic targets utilized in cancer immunotherapy over the past 5 years, as well as emerging targets that hold promise as potential therapeutic options in the application of mAbs for immunotherapy. Additionally, the review explores the mechanisms of actin of the currently employed mAbs in immunotherapy.
Fecha Publicación	2023
Tipo de Recurso	artículo de revisión
doi	10.3390/biomedicines11072086
Formato Recurso	PDF
Palabras Claves	cancer immunotherapy monoclonal antibody therapeutic targets
Ubicación del archivo	http://dx.doi.org/10.3390/biomedicines11072086
Categoría OCDE	Bioquímica y biología molecular Investigación y medicina experimental Farmacología y farmacia
Materias	cáncer inmunoterapia anticuerpo monoclonal dianas terapéuticas
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:001037956800001
Tipo de ruta	verde# dorado
Categoría WOS	Bioquímica y biología molecular Investigación y medicina experimental Farmacología y farmacia
Referencia del Financiador (Mandatado si es aplicable-repetible)	ANID-FONDECYT 3210142 ANID-FONDECYT 11180987 ANID-FONDECYT 1201734.