The emergence, impact, and evolution of human metapneumovirus variants from 2014 to 2021 in Spain
| Primer Autor |
Pumarola, Tomas
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| Co-autores |
Pinana, Maria
Gonzalez-Sanchez, Alejandra
Andres, Cristina
Abanto, Michel
Vila, Jorgina
Esperalba, Juliana
Moral, Noelia
Espartosa, Elena
Saubi, Narcis
Creus, Anna
Codina, Maria Gema
Folgueira, Dolores
Martinez-Urtaza, Jaime
Anton, Andres
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| Título |
The emergence, impact, and evolution of human metapneumovirus variants from 2014 to 2021 in Spain
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| Editorial |
W B SAUNDERS CO LTD
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| Revista |
JOURNAL OF INFECTION
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| Lenguaje |
en
|
| Resumen |
Background: Human metapneumovirus (HMPV) is an important aetiologic agent of respiratory tract infection (RTI). This study aimed to describe the prevalence, genetic diversity, and evolutionary dynamics of HMPV. Methods: Laboratory-confirmed HMPV were characterised based on partial-coding G gene sequences with MEGA.v6.0. WGS was performed with Illumina, and evolutionary analyses with Datamonkey and Nextstrain. Results: HMPV prevalence was 2.5%, peaking in February-April and with an alternation in the predominance of HMPV-A and -B until the emergence of SARS-CoV-2, not circulating until summer and autumn-winter 2021, with a higher prevalence and with the almost only circulation of A2c111dup. G and SH proteins were the most variable, and 70% of F protein was under negative selection. Mutation rate of HMPV genome was 6.95 x 10-4 substitutions/site/year. Conclusion: HMPV showed a significant morbidity until the emergence of SARS-CoV-2 pandemic in 2020, not circulating again until summer and autumn 2021, with a higher prevalence and with almost the only circulation of A2c111dup, probably due to a more efficient immune evasion mechanism. The F protein showed a very conserved nature, supporting the need for steric shielding. The tMRCA showed a recent emergence of the A2c variants carrying duplications, supporting the importance of virological surveillance. & COPY, 2023 The Author(s). Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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| Fecha Publicación |
2023
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| Tipo de Recurso |
artículo original
|
| doi |
10.1016/j.jinf.2023.05.004
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| Formato Recurso |
PDF
|
| Palabras Claves |
Human metapneumovirus
Duplication
Epidemiology
Evolution
Whole-genome sequencing
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| Ubicación del archivo | |
| Categoría OCDE |
Enfermedades infecciosas
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| Materias |
metaneumovirus humano
Duplicación
Epidemiología
Evolución
Secuenciación del genoma completo
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| Página de inicio (Recomendado-único) |
103.0
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| Página final (Recomendado-único) |
110
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| Identificador del recurso (Mandatado-único) |
artículo original
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| Versión del recurso (Recomendado-único) |
versión publicada
|
| License |
CC BY-NC-ND 4.0
|
| Condición de la licencia (Recomendado-repetible) |
CC BY-NC-ND 4.0
|
| Derechos de acceso |
acceso abierto
|
| Access Rights |
acceso abierto
|
| Id de Web of Science |
WOS:001040222200001
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| ISSN |
0163-4453
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| Tipo de ruta |
Verde# hibrida
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| Categoría WOS |
Enfermedades infecciosas
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
MINECO FISPI18/00685
REIPI RD16/0016/0003
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