Can We Predict Prostate Cancer Metastasis Based on Biomarkers? Where Are We Now?
Primer Autor |
San Francisco, Ignacio F.
|
Co-autores |
Rojas, Pablo A.
Bravo, Juan C.
Diaz, Jorge
Ebel, Luis
Urrutia, Sebastian
Prieto, Benjamin
Cerda-Infante, Javier
|
Título |
Can We Predict Prostate Cancer Metastasis Based on Biomarkers? Where Are We Now?
|
Editorial |
MDPI
|
Revista |
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
|
Lenguaje |
en
|
Resumen |
The incidence of prostate cancer (PC) has risen annually. PC mortality is explained by the metastatic disease (mPC). There is an intermediate scenario in which patients have non-mPC but have initiated a metastatic cascade through epithelial-mesenchymal transition. There is indeed a need for more and better tools to predict which patients will progress in the future to non-localized clinical disease or already have micrometastatic disease and, therefore, will clinically progress after primary treatment. Biomarkers for the prediction of mPC are still under development, there are few studies and not much evidence of their usefulness. This review is focused on tissue-based genomic biomarkers (TBGB) for the prediction of metastatic disease. We develop four main research questions that we attempt to answer according to the current evidence. Why is it important to predict metastatic disease? Which tests are available to predict metastatic disease? What impact should there be on clinical guidelines and clinical practice in predicting metastatic disease? What are the current prostate cancer treatments? The importance of predicting metastasis is fundamental given that, once metastasis is diagnosed, quality of life (QoL) and survival drop dramatically. There is still a need and space for more cost-effective TBGB tests that predict mPC disease.
|
Fecha Publicación |
2023
|
Tipo de Recurso |
artículo de revisión
|
doi |
10.3390/ijms241512508
|
Formato Recurso |
PDF
|
Palabras Claves |
prostate cancer
metastasis
tissue-based genomic biomarkers
|
Ubicación del archivo | |
Categoría OCDE |
Bioquímica y biología molecular
Química
|
Materias |
Cancer de prostata
metástasis
biomarcadores genómicos basados ??en tejidos
|
Identificador del recurso (Mandatado-único) |
artículo de revisión
|
Versión del recurso (Recomendado-único) |
versión publicada
|
License |
CC BY 4.0
|
Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
Derechos de acceso |
acceso abierto
|
Access Rights |
acceso abierto
|
Id de Web of Science |
WOS:001045530800001
|
ISSN |
1661-6596
|
Tipo de ruta |
verde# dorado
|
Categoría WOS |
Bioquímica y biología molecular
Química
|
Referencia del Financiador (Mandatado si es aplicable-repetible) |
CORFO 20IAT 130292
|