Repositorio UFRO · Omeka S

Can We Predict Prostate Cancer Metastasis Based on Biomarkers? Where Are We Now?

Primer Autor	San Francisco, Ignacio F.
Co-autores	Rojas, Pablo A. Bravo, Juan C. Diaz, Jorge Ebel, Luis Urrutia, Sebastian Prieto, Benjamin Cerda-Infante, Javier
Título	Can We Predict Prostate Cancer Metastasis Based on Biomarkers? Where Are We Now?
Editorial	MDPI
Revista	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje	en
Resumen	The incidence of prostate cancer (PC) has risen annually. PC mortality is explained by the metastatic disease (mPC). There is an intermediate scenario in which patients have non-mPC but have initiated a metastatic cascade through epithelial-mesenchymal transition. There is indeed a need for more and better tools to predict which patients will progress in the future to non-localized clinical disease or already have micrometastatic disease and, therefore, will clinically progress after primary treatment. Biomarkers for the prediction of mPC are still under development, there are few studies and not much evidence of their usefulness. This review is focused on tissue-based genomic biomarkers (TBGB) for the prediction of metastatic disease. We develop four main research questions that we attempt to answer according to the current evidence. Why is it important to predict metastatic disease? Which tests are available to predict metastatic disease? What impact should there be on clinical guidelines and clinical practice in predicting metastatic disease? What are the current prostate cancer treatments? The importance of predicting metastasis is fundamental given that, once metastasis is diagnosed, quality of life (QoL) and survival drop dramatically. There is still a need and space for more cost-effective TBGB tests that predict mPC disease.
Fecha Publicación	2023
Tipo de Recurso	artículo de revisión
doi	10.3390/ijms241512508
Formato Recurso	PDF
Palabras Claves	prostate cancer metastasis tissue-based genomic biomarkers
Ubicación del archivo	http://dx.doi.org/10.3390/ijms241512508
Categoría OCDE	Bioquímica y biología molecular Química
Materias	Cancer de prostata metástasis biomarcadores genómicos basados ??en tejidos
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:001045530800001
ISSN	1661-6596
Tipo de ruta	verde# dorado
Categoría WOS	Bioquímica y biología molecular Química
Referencia del Financiador (Mandatado si es aplicable-repetible)	CORFO 20IAT 130292