Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities

Primer Autor
Paz, Cristian
Co-autores
Perez, Rebeca
Burgos, Viviana
Marin, Victor
Camins, Antoni
Olloquequi, Jordi
Gonzalez-Chavarria, Ivan
Ulrich, Henning
Wyneke, Ursula
Luarte, Alejandro
Ortiz, Leandro
Título
Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities
Editorial
MDPI
Revista
ANTIOXIDANTS
Lenguaje
en
Resumen
Neurodegenerative disorders are characterized by a progressive process of degeneration and neuronal death, where oxidative stress and neuroinflammation are key factors that contribute to the progression of these diseases. Therefore, two major pathways involved in these pathologies have been proposed as relevant therapeutic targets: The nuclear transcription factor erythroid 2 (Nrf2), which responds to oxidative stress with cytoprotecting activity, and the nuclear factor NF-kappa B pathway, which is highly related to the neuroinflammatory process by promoting cytokine expression. Caffeic acid phenethyl ester (CAPE) is a phenylpropanoid naturally found in propolis that shows important biological activities, including neuroprotective activity by modulating the Nrf2 and NF-kappa B pathways, promoting antioxidant enzyme expression and inhibition of proinflammatory cytokine expression. Its simple chemical structure has inspired the synthesis of many derivatives, with aliphatic and/or aromatic moieties, some of which have improved the biological properties. Moreover, new drug delivery systems increase the bioavailability of these compounds in vivo, allowing its transcytosis through the blood-brain barrier, thus protecting brain cells from the increased inflammatory status associated to neurodegenerative and psychiatric disorders. This review summarizes the biosynthesis and chemical synthesis of CAPE derivatives, their miscellaneous activities, and relevant studies (from 2010 to 2023), addressing their neuroprotective activity in vitro and in vivo.
Fecha Publicación
2023
Tipo de Recurso
artículo de revisión
doi
10.3390/antiox12081500
Formato Recurso
PDF
Palabras Claves
caffeic acid phenethyl ester
CAPE derivatives
anti-inflammatory
NF-kappa B
antioxidant
Nrf2
neuroprotection
Ubicación del archivo
Categoría OCDE
Bioquímica y biología molecular
Farmacología y farmacia
Ciencia y tecnología de los alimentos
Materias
éster fenetílico del ácido cafeico
derivados CAPE
antiinflamatorio
NF-kappa B
antioxidante
Nrf2
neuroprotección
Identificador del recurso (Mandatado-único)
artículo de revisión
Versión del recurso (Recomendado-único)
versión publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:001055855900001
Tipo de ruta
verde# dorado
Categoría WOS
Bioquímica y biología molecular
Farmacología y farmacia
Ciencia y tecnología de los alimentos
Referencia del Financiador (Mandatado si es aplicable-repetible)
ANID-FONDECYT 1220831
FAPESP 2018/07366-4
ANID FONDECYT 1220831
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