Repositorio UFRO · Omeka S

Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities

Primer Autor	Paz, Cristian
Co-autores	Perez, Rebeca Burgos, Viviana Marin, Victor Camins, Antoni Olloquequi, Jordi Gonzalez-Chavarria, Ivan Ulrich, Henning Wyneke, Ursula Luarte, Alejandro Ortiz, Leandro
Título	Caffeic Acid Phenethyl Ester (CAPE): Biosynthesis, Derivatives and Formulations with Neuroprotective Activities
Editorial	MDPI
Revista	ANTIOXIDANTS
Lenguaje	en
Resumen	Neurodegenerative disorders are characterized by a progressive process of degeneration and neuronal death, where oxidative stress and neuroinflammation are key factors that contribute to the progression of these diseases. Therefore, two major pathways involved in these pathologies have been proposed as relevant therapeutic targets: The nuclear transcription factor erythroid 2 (Nrf2), which responds to oxidative stress with cytoprotecting activity, and the nuclear factor NF-kappa B pathway, which is highly related to the neuroinflammatory process by promoting cytokine expression. Caffeic acid phenethyl ester (CAPE) is a phenylpropanoid naturally found in propolis that shows important biological activities, including neuroprotective activity by modulating the Nrf2 and NF-kappa B pathways, promoting antioxidant enzyme expression and inhibition of proinflammatory cytokine expression. Its simple chemical structure has inspired the synthesis of many derivatives, with aliphatic and/or aromatic moieties, some of which have improved the biological properties. Moreover, new drug delivery systems increase the bioavailability of these compounds in vivo, allowing its transcytosis through the blood-brain barrier, thus protecting brain cells from the increased inflammatory status associated to neurodegenerative and psychiatric disorders. This review summarizes the biosynthesis and chemical synthesis of CAPE derivatives, their miscellaneous activities, and relevant studies (from 2010 to 2023), addressing their neuroprotective activity in vitro and in vivo.
Fecha Publicación	2023
Tipo de Recurso	artículo de revisión
doi	10.3390/antiox12081500
Formato Recurso	PDF
Palabras Claves	caffeic acid phenethyl ester CAPE derivatives anti-inflammatory NF-kappa B antioxidant Nrf2 neuroprotection
Ubicación del archivo	http://dx.doi.org/10.3390/antiox12081500
Categoría OCDE	Bioquímica y biología molecular Farmacología y farmacia Ciencia y tecnología de los alimentos
Materias	éster fenetílico del ácido cafeico derivados CAPE antiinflamatorio NF-kappa B antioxidante Nrf2 neuroprotección
Identificador del recurso (Mandatado-único)	artículo de revisión
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:001055855900001
Tipo de ruta	verde# dorado
Categoría WOS	Bioquímica y biología molecular Farmacología y farmacia Ciencia y tecnología de los alimentos
Referencia del Financiador (Mandatado si es aplicable-repetible)	ANID-FONDECYT 1220831 FAPESP 2018/07366-4 ANID FONDECYT 1220831