Brainstem Modulates Parkinsonism-Induced Orofacial Sensorimotor Dysfunctions

Primer Autor
Del-Bel, Elaine
Co-autores
Nascimento, Glauce Crivelaro
Jacob, Gabrielle
Milan, Bruna Araujo
Leal-Luiz, Gabrielli
Malzone, Bruno Lima
Vivanco-Estela, Airam Nicole
Escobar-Espinal, Daniela
Dias, Fernando Jose
Título
Brainstem Modulates Parkinsonism-Induced Orofacial Sensorimotor Dysfunctions
Editorial
MDPI
Revista
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje
en
Resumen
Parkinson's Disease (PD), treated with the dopamine precursor l-3,4-dihydroxyphenylalanine (L-DOPA), displays motor and non-motor orofacial manifestations. We investigated the pathophysiologic mechanisms of the lateral pterygoid muscles (LPMs) and the trigeminal system related to PD-induced orofacial manifestations. A PD rat model was produced by unilateral injection of 6-hydroxydopamine into the medial forebrain bundle. Abnormal involuntary movements (dyskinesia) and nociceptive responses were determined. We analyzed the immunodetection of Fos-B and microglia/astrocytes in trigeminal and facial nuclei and morphological markers in the LPMs. Hyperalgesia response was increased in hemiparkinsonian and dyskinetic rats. Hemiparkinsonism increased slow skeletal myosin fibers in the LPMs, while in the dyskinetic ones, these fibers decreased in the contralateral side of the lesion. Bilateral increased glycolytic metabolism and an inflammatory muscle profile were detected in dyskinetic rats. There was increased Fos-B expression in the spinal nucleus of lesioned rats and in the motor and facial nucleus in L-DOPA-induced dyskinetic rats in the contralateral side of the lesion. Glial cells were increased in the facial nucleus on the contralateral side of the lesion. Overall, spinal trigeminal nucleus activation may be associated with orofacial sensorial impairment in Parkinsonian rats, while a fatigue profile on LPMs is suggested in L-DOPA-induced dyskinesia when the motor and facial nucleus are activated.
Fecha Publicación
2023
Tipo de Recurso
artículo original
doi
10.3390/ijms241512270
Formato Recurso
PDF
Palabras Claves
brain function
pain
neuroscience
neurobiology
neurotoxicity
muscle biology
Ubicación del archivo
Categoría OCDE
Bioquímica y biología molecular
Química
Materias
función del cerebro
dolor
neurociencia
neurobiología
neurotoxicidad
biología muscular
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
versión publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:001045522900001
ISSN
1661-6596
Tipo de ruta
verde# dorado
Categoría WOS
Bioquímica y biología molecular
Química
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