Repositorio UFRO · Omeka S

Brainstem Modulates Parkinsonism-Induced Orofacial Sensorimotor Dysfunctions

Primer Autor	Del-Bel, Elaine
Co-autores	Nascimento, Glauce Crivelaro Jacob, Gabrielle Milan, Bruna Araujo Leal-Luiz, Gabrielli Malzone, Bruno Lima Vivanco-Estela, Airam Nicole Escobar-Espinal, Daniela Dias, Fernando Jose
Título	Brainstem Modulates Parkinsonism-Induced Orofacial Sensorimotor Dysfunctions
Editorial	MDPI
Revista	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Lenguaje	en
Resumen	Parkinson's Disease (PD), treated with the dopamine precursor l-3,4-dihydroxyphenylalanine (L-DOPA), displays motor and non-motor orofacial manifestations. We investigated the pathophysiologic mechanisms of the lateral pterygoid muscles (LPMs) and the trigeminal system related to PD-induced orofacial manifestations. A PD rat model was produced by unilateral injection of 6-hydroxydopamine into the medial forebrain bundle. Abnormal involuntary movements (dyskinesia) and nociceptive responses were determined. We analyzed the immunodetection of Fos-B and microglia/astrocytes in trigeminal and facial nuclei and morphological markers in the LPMs. Hyperalgesia response was increased in hemiparkinsonian and dyskinetic rats. Hemiparkinsonism increased slow skeletal myosin fibers in the LPMs, while in the dyskinetic ones, these fibers decreased in the contralateral side of the lesion. Bilateral increased glycolytic metabolism and an inflammatory muscle profile were detected in dyskinetic rats. There was increased Fos-B expression in the spinal nucleus of lesioned rats and in the motor and facial nucleus in L-DOPA-induced dyskinetic rats in the contralateral side of the lesion. Glial cells were increased in the facial nucleus on the contralateral side of the lesion. Overall, spinal trigeminal nucleus activation may be associated with orofacial sensorial impairment in Parkinsonian rats, while a fatigue profile on LPMs is suggested in L-DOPA-induced dyskinesia when the motor and facial nucleus are activated.
Fecha Publicación	2023
Tipo de Recurso	artículo original
doi	10.3390/ijms241512270
Formato Recurso	PDF
Palabras Claves	brain function pain neuroscience neurobiology neurotoxicity muscle biology
Ubicación del archivo	http://dx.doi.org/10.3390/ijms241512270
Categoría OCDE	Bioquímica y biología molecular Química
Materias	función del cerebro dolor neurociencia neurobiología neurotoxicidad biología muscular
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:001045522900001
ISSN	1661-6596
Tipo de ruta	verde# dorado
Categoría WOS	Bioquímica y biología molecular Química