Associations of Antibiotics, Hormonal Therapies, Oral Contraceptives, and Long-Term NSAIDS With Inflammatory Bowel Disease: Results From the Prospective Urban Rural Epidemiology (PURE) Study

Primer Autor
Narula, Neeraj
Co-autores
Wong, Emily C. L.
Pray, Cara
Marshall, John K.
Rangarajan, Sumathy
Islam, Shofiqul
Bahonar, Ahmad
Alhabib, Khalid F.
Kontsevaya, Anna
Ariffin, Farnaza
Co, Homer U.
Al Sharief, Wadeia
Szuba, Andrzej
Wielgosz, Andreas
Diaz, Maria Luz
Yusuf, Rita
Kruger, Lanthe
Soman, Biju
Li, Yang
Wang, Chuangshi
Yin, Lu
Mirrakhimov, Erkin
Lanas, Fernando
Davletov, Kairat
Rosengren, Annika
Lopez-Jaramillo, Patricio
Khatib, Rasha
Oguz, Aytekin
Iqbal, Romaina
Yeates, Karen
Avezum, Alvaro
Reinisch, Walter
Moayyedi, Paul
Yusuf, Salim
Título
Associations of Antibiotics, Hormonal Therapies, Oral Contraceptives, and Long-Term NSAIDS With Inflammatory Bowel Disease: Results From the Prospective Urban Rural Epidemiology (PURE) Study
Editorial
ELSEVIER SCIENCE INC
Revista
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
Lenguaje
en
Resumen
BACKGROUND & AIMS: Several medications have been suspected to contribute to the etiology of inflammatory bowel disease (IBD). This study assessed the association between medication use and the risk of developing IBD using the Prospective Urban Rural Epidemiology cohort.METHODS: This was a prospective cohort study of 133,137 individuals between the ages of 20 and 80 from 24 countries. Country-specific validated questionnaires documented baseline and follow-up medication use. Participants were followed up prospectively at least every 3 years. The main outcome was the development of IBD, including Crohn's disease (CD) and ulcerative colitis (UC). Short-term (baseline but not follow-up use) and long-term use (baseline and subsequent followup use) were evaluated. Results are presented as adjusted odds ratios (aORs) with 95% CIs. RESULTS: During a median follow-up period of 11.0 years (interquartile range, 9.2-12.2 y), there were 571 incident IBD cases (143 CD and 428 UC). Incident IBD was associated significantly with baseline antibiotic (aOR, 2.81, 95% CI, 1.67-4.73, P = .0001) and hormonal medication use (aOR, 4.43, 95% CI, 1.78-11.01, P = .001). Among females, previous or current oral contraceptive use also was associated with IBD development (aOR, 2.17, 95% CI, 1.70-2.77, P < .001). Nonsteroidal anti-inflammatory drug users also were observed to have increased odds of IBD (aOR, 1.80, 95% CI, 1.23-2.64, P = .002), which was driven by long-term use (aOR, 5.58, 95% CI, 2.26-13.80, P < .001). All significant results were consistent in direction for CD and UC with low heterogeneity.CONCLUSIONS: Antibiotics, hormonal medications, oral contraceptives, and long-term nonsteroidal antiinflammatory drug use were associated with increased odds of incident IBD after adjustment for covariates.
Fecha Publicación
2023
Tipo de Recurso
artículo original
doi
10.1016/j.cgh.2022.11.037
Formato Recurso
PDF
Palabras Claves
Crohn's Disease
NSAIDS
Ulcerative Colitis
Oral Contraceptive
Estrogen
Hormone
IBD
Antibiotics
Ubicación del archivo
Categoría OCDE
Gastroenterología y Hepatología
Materias
Enfermedad de Crohn
AINE
Colitis ulcerosa
Anticonceptivo oral
Estrógeno
Hormona
EII
antibióticos
Página de inicio (Recomendado-único)
2649.0
Página final (Recomendado-único)
+
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
versión publicada
Derechos de acceso
metadata
Access Rights
metadata
Id de Web of Science
WOS:001070331900001
ISSN
1542-3565
Categoría WOS
Gastroenterología y Hepatología
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