Repositorio UFRO · Omeka S

Associations of Antibiotics, Hormonal Therapies, Oral Contraceptives, and Long-Term NSAIDS With Inflammatory Bowel Disease: Results From the Prospective Urban Rural Epidemiology (PURE) Study

Primer Autor	Narula, Neeraj
Co-autores	Wong, Emily C. L. Pray, Cara Marshall, John K. Rangarajan, Sumathy Islam, Shofiqul Bahonar, Ahmad Alhabib, Khalid F. Kontsevaya, Anna Ariffin, Farnaza Co, Homer U. Al Sharief, Wadeia Szuba, Andrzej Wielgosz, Andreas Diaz, Maria Luz Yusuf, Rita Kruger, Lanthe Soman, Biju Li, Yang Wang, Chuangshi Yin, Lu Mirrakhimov, Erkin Lanas, Fernando Davletov, Kairat Rosengren, Annika Lopez-Jaramillo, Patricio Khatib, Rasha Oguz, Aytekin Iqbal, Romaina Yeates, Karen Avezum, Alvaro Reinisch, Walter Moayyedi, Paul Yusuf, Salim
Título	Associations of Antibiotics, Hormonal Therapies, Oral Contraceptives, and Long-Term NSAIDS With Inflammatory Bowel Disease: Results From the Prospective Urban Rural Epidemiology (PURE) Study
Editorial	ELSEVIER SCIENCE INC
Revista	CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
Lenguaje	en
Resumen	BACKGROUND & AIMS: Several medications have been suspected to contribute to the etiology of inflammatory bowel disease (IBD). This study assessed the association between medication use and the risk of developing IBD using the Prospective Urban Rural Epidemiology cohort.METHODS: This was a prospective cohort study of 133,137 individuals between the ages of 20 and 80 from 24 countries. Country-specific validated questionnaires documented baseline and follow-up medication use. Participants were followed up prospectively at least every 3 years. The main outcome was the development of IBD, including Crohn's disease (CD) and ulcerative colitis (UC). Short-term (baseline but not follow-up use) and long-term use (baseline and subsequent followup use) were evaluated. Results are presented as adjusted odds ratios (aORs) with 95% CIs. RESULTS: During a median follow-up period of 11.0 years (interquartile range, 9.2-12.2 y), there were 571 incident IBD cases (143 CD and 428 UC). Incident IBD was associated significantly with baseline antibiotic (aOR, 2.81, 95% CI, 1.67-4.73, P = .0001) and hormonal medication use (aOR, 4.43, 95% CI, 1.78-11.01, P = .001). Among females, previous or current oral contraceptive use also was associated with IBD development (aOR, 2.17, 95% CI, 1.70-2.77, P < .001). Nonsteroidal anti-inflammatory drug users also were observed to have increased odds of IBD (aOR, 1.80, 95% CI, 1.23-2.64, P = .002), which was driven by long-term use (aOR, 5.58, 95% CI, 2.26-13.80, P < .001). All significant results were consistent in direction for CD and UC with low heterogeneity.CONCLUSIONS: Antibiotics, hormonal medications, oral contraceptives, and long-term nonsteroidal antiinflammatory drug use were associated with increased odds of incident IBD after adjustment for covariates.
Fecha Publicación	2023
Tipo de Recurso	artículo original
doi	10.1016/j.cgh.2022.11.037
Formato Recurso	PDF
Palabras Claves	Crohn's Disease NSAIDS Ulcerative Colitis Oral Contraceptive Estrogen Hormone IBD Antibiotics
Ubicación del archivo	http://dx.doi.org/10.1016/j.cgh.2022.11.037
Categoría OCDE	Gastroenterología y Hepatología
Materias	Enfermedad de Crohn AINE Colitis ulcerosa Anticonceptivo oral Estrógeno Hormona EII antibióticos
Página de inicio (Recomendado-único)	2649.0
Página final (Recomendado-único)	+
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	versión publicada
Derechos de acceso	metadata
Access Rights	metadata
Id de Web of Science	WOS:001070331900001
ISSN	1542-3565
Categoría WOS	Gastroenterología y Hepatología