Repositorio
Institucional

Sans-Serramitjana, Eulalia

Obreque, Macarena

Munoz, Fernanda

Zaror, Carlos

Mora, Maria de La Luz

Vinas, Miguel

Betancourt, Pablo

Antimicrobial Activity of Selenium Nanoparticles (SeNPs) against Potentially Pathogenic Oral Microorganisms: A Scoping Review

MDPI

PHARMACEUTICS

en

Biofilms are responsible for the most prevalent oral infections such as caries, periodontal disease, and pulp and periapical lesions, which affect the quality of life of people. Antibiotics have been widely used to treat these conditions as therapeutic and prophylactic compounds. However, due to the emergence of microbial resistance to antibiotics, there is an urgent need to develop and evaluate new antimicrobial agents. This scoping review offers an extensive and detailed synthesis of the potential role of selenium nanoparticles (SeNPs) in combating oral pathogens responsible for causing infectious diseases. A systematic search was conducted up until May 2022, encompassing the MEDLINE, Embase, Scopus, and Lilacs databases. We included studies focused on evaluating the antimicrobial efficacy of SeNPs on planktonic and biofilm forms and their side effects in in vitro studies. The selection process and data extraction were carried out by two researchers independently. A qualitative synthesis of the results was performed. A total of twenty-two articles were considered eligible for this scoping review. Most of the studies reported relevant antimicrobial efficacy against C. albicans, S. mutans, E. faecalis, and P. gingivalis, as well as effective antioxidant activity and limited toxicity. Further research is mandatory to critically assess the effectiveness of this alternative treatment in ex vivo and in vivo settings, with detailed information about SeNPs concentrations employed, their physicochemical properties, and the experimental conditions to provide enough evidence to address the construction and development of well-designed and safe protocols.

2023

artículo de revisión

10.3390/pharmaceutics15092253

PDF

selenium nanoparticles

antimicrobial activity

biofilm

planktonic state

oral pathogens

Farmacología y farmacia

nanopartículas de selenio

actividad antimicrobiana

biopelícula

estado planctónico

patógenos orales

artículo de revisión

versión publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

WOS:001077757800001

verde# dorado

Farmacología y farmacia

ANID-FONDECYT 3210302

UFRO DIUFRO DI21-0060.

ANID FONDECYT 3210302

UFRO DI21-0060