Repositorio UFRO · Omeka S

Healing Effect of a Nano-Functionalized Medical-Grade Honey for the Treatment of Infected Wounds

Primer Autor	del Sol, Mariano
Co-autores	Salvo, Jessica Sandoval, Cristian Schencke, Carolina Acevedo, Francisca
Título	Healing Effect of a Nano-Functionalized Medical-Grade Honey for the Treatment of Infected Wounds
Editorial	MDPI
Revista	PHARMACEUTICS
Lenguaje	en
Resumen	Based on the qualities of Ulmo honey (Eucryphia cordifolia), a medical-grade honey (Ulmoplus (R)) has been developed. Relevant to this, the use of copper represents an emerging therapy for the treatment of wounds. Therefore, the aim of this study was to see how this medical-grade honey with copper nanoparticles (CuNPs) helped to heal infected or non-infected wounds. Twenty-four guinea pigs (Cavia porcellus) were divided into four groups for phase 1 (without and with infection, U + F1 and U + F2), and two groups for phase 2 (selected formulation, without and with infection, U + F2NI and U + F2I). Bacteriological and histopathological studies, collagen fibers content evaluation, and stereological analysis were performed. The selected formulation displayed the same antibacterial potency as Ulmoplus (R), indicating that this medical-grade honey by itself can be used as an antibacterial agent. However, the evaluation of collagen content demonstrated a significant increase in fibroblast and type III collagen fibers for infected and uninfected groups, which correlated with the histopathological study. Therefore, it is correct to affirm that adding CuNPs to Ulmoplus (R) improved the maturation of collagen fibers. Finally, polymorphonuclear cells presented similar values between experimental groups, which would indicate that the formulation under study was able to regulate the inflammatory process despite their infectious condition.
Fecha Publicación	2023
Tipo de Recurso	artículo original
doi	10.3390/pharmaceutics15092187
Formato Recurso	PDF
Palabras Claves	angiogenesis burns guinea pig regeneration
Ubicación del archivo	http://dx.doi.org/10.3390/pharmaceutics15092187
Categoría OCDE	Farmacología y farmacia
Materias	angiogénesis quemaduras conejillo de indias regeneración
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:001074558900001
Tipo de ruta	verde# dorado
Categoría WOS	Farmacología y farmacia
Referencia del Financiador (Mandatado si es aplicable-repetible)	UFRO DI22-0063 ANID-PFCHA 2019-21190160 ANID PFCHA 2019-21190160