Small molecule anion carriers facilitate lactate transport in model liposomes and cells
| Primer Autor |
Quesada, Roberto
|
| Co-autores |
Carrillo, Daniel Alonso-
Arias-Betancur, Alain
Carreira-Barral, Israel
Fontova, Pere
Soto-Cerrato, Vanessa
Garcia-Valverde, Maria
Perez-Tomas, Ricardo
|
| Título |
Small molecule anion carriers facilitate lactate transport in model liposomes and cells
|
| Editorial |
CELL PRESS
|
| Revista |
ISCIENCE
|
| Lenguaje |
en
|
| Resumen |
An excessive production of lactate by cancer cells fosters tumor growth and metastasis. Therefore, targeting lactate metabolism and transport offers a new therapeutic strategy against cancer, based on dependency of some cancer cells for lactate as energy fuel or as oncogenic signal. Herein we present a family of anionophores based on the structure of click-tambjamines that have proved to be extremely active lactate carriers across phospholipid membranes. Compound 1, the most potent lactate transmembrane carrier, was studied in HeLa cells. The use of a monocarboxylate transporters (MCTs) inhibitor proved that 1 is an active lactate transporter in living cells, confirming the results obtained in phospholipid vesicles. Moreover, an additive effect of compound 1 with cisplatin was observed in HeLa cells. Identification of active lactate anionophores working in living cells opens up ways to exploit this class of compounds as molecular tools and drugs addressing dysregulated lactate metabolism.
|
| Fecha Publicación |
2023
|
| Tipo de Recurso |
artículo original
|
| doi |
10.1016/j.isci.2023.107898
|
| Formato Recurso |
PDF
|
| Palabras Claves |
Biochemistry
Biological sciences
Molecular biology
Natural sciences
|
| Ubicación del archivo | |
| Categoría OCDE |
Ciencia y tecnología: otros temas
|
| Materias |
Bioquímica
Ciencias Biologicas
Biología Molecular
Ciencias Naturales
|
| Identificador del recurso (Mandatado-único) |
artículo original
|
| Versión del recurso (Recomendado-único) |
versión publicada
|
| License |
CC BY-NC-ND 4.0
|
| Condición de la licencia (Recomendado-repetible) |
CC BY-NC-ND 4.0
|
| Derechos de acceso |
acceso abierto
|
| Access Rights |
acceso abierto
|
| Id de Web of Science |
WOS:001085862700001
|
| Tipo de ruta |
verde# dorado
|
| Categoría WOS |
Ciencia y tecnología: otros temas
|
| Referencia del Financiador (Mandatado si es aplicable-repetible) |
EducaCyL BU067P20
MICINN PID2020-117610RB-I00
ANID 72200156
|
cienciaabierta.ufro.cl
ciencia.abierta@ufrontera.cl