Repositorio UFRO · Omeka S

Small molecule anion carriers facilitate lactate transport in model liposomes and cells

Primer Autor	Quesada, Roberto
Co-autores	Carrillo, Daniel Alonso- Arias-Betancur, Alain Carreira-Barral, Israel Fontova, Pere Soto-Cerrato, Vanessa Garcia-Valverde, Maria Perez-Tomas, Ricardo
Título	Small molecule anion carriers facilitate lactate transport in model liposomes and cells
Editorial	CELL PRESS
Revista	ISCIENCE
Lenguaje	en
Resumen	An excessive production of lactate by cancer cells fosters tumor growth and metastasis. Therefore, targeting lactate metabolism and transport offers a new therapeutic strategy against cancer, based on dependency of some cancer cells for lactate as energy fuel or as oncogenic signal. Herein we present a family of anionophores based on the structure of click-tambjamines that have proved to be extremely active lactate carriers across phospholipid membranes. Compound 1, the most potent lactate transmembrane carrier, was studied in HeLa cells. The use of a monocarboxylate transporters (MCTs) inhibitor proved that 1 is an active lactate transporter in living cells, confirming the results obtained in phospholipid vesicles. Moreover, an additive effect of compound 1 with cisplatin was observed in HeLa cells. Identification of active lactate anionophores working in living cells opens up ways to exploit this class of compounds as molecular tools and drugs addressing dysregulated lactate metabolism.
Fecha Publicación	2023
Tipo de Recurso	artículo original
doi	10.1016/j.isci.2023.107898
Formato Recurso	PDF
Palabras Claves	Biochemistry Biological sciences Molecular biology Natural sciences
Ubicación del archivo	http://dx.doi.org/10.1016/j.isci.2023.107898
Categoría OCDE	Ciencia y tecnología: otros temas
Materias	Bioquímica Ciencias Biologicas Biología Molecular Ciencias Naturales
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY-NC-ND 4.0
Condición de la licencia (Recomendado-repetible)	CC BY-NC-ND 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:001085862700001
Tipo de ruta	verde# dorado
Categoría WOS	Ciencia y tecnología: otros temas
Referencia del Financiador (Mandatado si es aplicable-repetible)	EducaCyL BU067P20 MICINN PID2020-117610RB-I00 ANID 72200156