Repositorio UFRO · Omeka S

Modulation of the Cardiovascular Effects of Polycyclic Aromatic Hydrocarbons: Physical Exercise as a Protective Strategy

Primer Autor	Salazar, Luis A.
Co-autores	Rojas, Gabriel A. Saavedra, Nicolas Morales, Cristian Saavedra, Kathleen Lanas, Fernando
Título	Modulation of the Cardiovascular Effects of Polycyclic Aromatic Hydrocarbons: Physical Exercise as a Protective Strategy
Editorial	MDPI
Revista	TOXICS
Lenguaje	en
Resumen	Exposure to polycyclic aromatic hydrocarbons (PAHs) present in air pollution increases cardiovascular risk. On the contrary, physical exercise is a widely used therapeutic approach to mitigate cardiovascular risk, but its efficacy in an environment of air pollution, particularly with PAHs, remains unclear. This study investigates the effects of exercise on inflammation, endothelial dysfunction, and REDOX imbalance due to PAH exposure using a mouse model. Twenty male BALB/c mice were subjected to a mixture of PAHs (phenanthrene, fluoranthene, pyrene) in conjunction with aerobic exercise. The investigation evaluated serum levels of inflammatory cytokines, gene expression linked to inflammatory markers, endothelial dysfunction, and REDOX imbalance in aortic tissues. Furthermore, the study evaluated the expression of the ICAM-1 and VCAM-1 proteins. Exercise led to notable changes in serum inflammatory cytokines, as well as the modulation of genes associated with endothelial dysfunction and REDOX imbalance in aortic tissue. In turn, exercise produced a modulation in the protein expression of ICAM-1 and VCAM-1. The findings implicate the potential of exercise to counter PAH-induced damage, as demonstrated by changes in markers. In conclusion, exercise could mitigate the adverse effects related to exposure to PAHs present in air pollution, as evidenced by changes in inflammatory markers, endothelial dysfunction, and REDOX imbalance.
Fecha Publicación	2023
Tipo de Recurso	artículo original
doi	10.3390/toxics11100844
Formato Recurso	PDF
Palabras Claves	polycyclic aromatic hydrocarbons cardiovascular risk aerobic exercise
Ubicación del archivo	http://dx.doi.org/10.3390/toxics11100844
Categoría OCDE	Ciencias ambientales y ecología Toxicología
Materias	hidrocarburos aromáticos policíclicos riesgo cardiovascular ejercicio aerobico
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:001089528200001
Tipo de ruta	verde# dorado
Categoría WOS	Ciencias ambientales y ecología Toxicología