Modulation of the Cardiovascular Effects of Polycyclic Aromatic Hydrocarbons: Physical Exercise as a Protective Strategy
| Primer Autor |
Salazar, Luis A.
|
| Co-autores |
Rojas, Gabriel A.
Saavedra, Nicolas
Morales, Cristian
Saavedra, Kathleen
Lanas, Fernando
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| Título |
Modulation of the Cardiovascular Effects of Polycyclic Aromatic Hydrocarbons: Physical Exercise as a Protective Strategy
|
| Editorial |
MDPI
|
| Revista |
TOXICS
|
| Lenguaje |
en
|
| Resumen |
Exposure to polycyclic aromatic hydrocarbons (PAHs) present in air pollution increases cardiovascular risk. On the contrary, physical exercise is a widely used therapeutic approach to mitigate cardiovascular risk, but its efficacy in an environment of air pollution, particularly with PAHs, remains unclear. This study investigates the effects of exercise on inflammation, endothelial dysfunction, and REDOX imbalance due to PAH exposure using a mouse model. Twenty male BALB/c mice were subjected to a mixture of PAHs (phenanthrene, fluoranthene, pyrene) in conjunction with aerobic exercise. The investigation evaluated serum levels of inflammatory cytokines, gene expression linked to inflammatory markers, endothelial dysfunction, and REDOX imbalance in aortic tissues. Furthermore, the study evaluated the expression of the ICAM-1 and VCAM-1 proteins. Exercise led to notable changes in serum inflammatory cytokines, as well as the modulation of genes associated with endothelial dysfunction and REDOX imbalance in aortic tissue. In turn, exercise produced a modulation in the protein expression of ICAM-1 and VCAM-1. The findings implicate the potential of exercise to counter PAH-induced damage, as demonstrated by changes in markers. In conclusion, exercise could mitigate the adverse effects related to exposure to PAHs present in air pollution, as evidenced by changes in inflammatory markers, endothelial dysfunction, and REDOX imbalance.
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| Fecha Publicación |
2023
|
| Tipo de Recurso |
artículo original
|
| doi |
10.3390/toxics11100844
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| Formato Recurso |
PDF
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| Palabras Claves |
polycyclic aromatic hydrocarbons
cardiovascular risk
aerobic exercise
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| Ubicación del archivo | |
| Categoría OCDE |
Ciencias ambientales y ecología
Toxicología
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| Materias |
hidrocarburos aromáticos policíclicos
riesgo cardiovascular
ejercicio aerobico
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| Identificador del recurso (Mandatado-único) |
artículo original
|
| Versión del recurso (Recomendado-único) |
versión publicada
|
| License |
CC BY 4.0
|
| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
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| Access Rights |
acceso abierto
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| Id de Web of Science |
WOS:001089528200001
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| Tipo de ruta |
verde# dorado
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| Categoría WOS |
Ciencias ambientales y ecología
Toxicología
|
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