Insights into Co-Cultivation of Photosynthetic Microorganisms for Novel Molecule Discovery and Enhanced Production of Specialized Metabolites
| Primer Autor |
Rojas-Villalta, Dorian
|
| Co-autores |
Gomez-Espinoza, Olman
Murillo-Vega, Francinie
Villalta-Romero, Fabian
Guerrero, Maritza
Guillen-Watson, Rossy
Nunez-Montero, Kattia
|
| Título |
Insights into Co-Cultivation of Photosynthetic Microorganisms for Novel Molecule Discovery and Enhanced Production of Specialized Metabolites
|
| Editorial |
MDPI
|
| Revista |
FERMENTATION-BASEL
|
| Lenguaje |
en
|
| Resumen |
Meso- and extremophilic microalgae and cyanobacteria have a wide range of biotechnological applications. However, the industrial demand for bioactive molecules and the redundancy of these molecules has resulted in a need for new methodologies for enhanced production and the discovery of specialized metabolites. Co-cultivation has been established as a promising approach to addressing these challenges. In this context, this work aimed to describe the state of the art of the co-cultivation method involving meso- and extremophilic photosynthetic microorganisms, as well as discuss the advantages, challenges, and limitations of this approach. Co-culture is defined as an ecology-driven method in which various symbiotic interactions involving cyanobacteria and microalgae can be used to explore new compounds and enhanced production. Promising results regarding new bioactive metabolite expression and increased production through co-cultivation-based research support that idea. Also, the metabolic diversity and evolutionary adaptations of photosynthetic microorganisms to thrive in extreme environments could improve the efficiency of co-cultivation by allowing the implementation of these microorganisms. However, the complexity of ecological interactions and lack of standardization for co-cultivation protocols are obstacles to its success and scientific validation. Further research in symbiotic interplays using -omics and genetic engineering, and predictive experimental designs for co-cultures are needed to overcome these limitations.
|
| Fecha Publicación |
2023
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| Tipo de Recurso |
artículo de revisión
|
| doi |
10.3390/fermentation9110941
|
| Formato Recurso |
PDF
|
| Palabras Claves |
bioactive metabolites
ecological interactions
co-culture
new bioprospecting
algae
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| Ubicación del archivo | |
| Categoría OCDE |
Biotecnología y microbiología aplicada
Ciencia y tecnología de los alimentos
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| Materias |
metabolitos bioactivos
interacciones ecológicas
cocultura
nueva bioprospección
algas
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| Identificador del recurso (Mandatado-único) |
artículo de revisión
|
| Versión del recurso (Recomendado-único) |
versión publicada
|
| License |
CC BY 4.0
|
| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
|
| Derechos de acceso |
acceso abierto
|
| Access Rights |
acceso abierto
|
| Id de Web of Science |
WOS:001119834200001
|
| Tipo de ruta |
verde# dorado
|
| Categoría WOS |
Biotecnología y microbiología aplicada
Ciencia y tecnología de los alimentos
|
| Referencia del Financiador (Mandatado si es aplicable-repetible) |
TEC
|
cienciaabierta.ufro.cl
ciencia.abierta@ufrontera.cl