Repositorio UFRO · Omeka S

Lipidomic analysis identified potential predictive biomarkers of statin response in subjects with Familial hypercholesterolemia

Primer Autor	Hirata, Mario Hiroyuki
Co-autores	Cerda, Alvaro Bortolin, Raul Hernandes Yoshinaga, Marcos Yukio de Freitas, Renata Caroline Costa Dagli-Hernandez, Carolina Borges, Jessica Bassani de Oliveira, Victor Fernandes Goncalves, Rodrigo Marques Faludi, Andre Arpad Bastos, Gisele Medeiros Hirata, Rosario Dominguez Crespo
Título	Lipidomic analysis identified potential predictive biomarkers of statin response in subjects with Familial hypercholesterolemia
Editorial	ELSEVIER IRELAND LTD
Revista	CHEMISTRY AND PHYSICS OF LIPIDS
Lenguaje	en
Resumen	Familial hypercholesterolemia (FH) is a disorder of lipid metabolism that causes elevated low-density lipoprotein cholesterol (LDL-c) and increased premature atherosclerosis risk. Statins inhibit endogenous cholesterol biosynthesis, which reduces LDL-c plasma levels and prevent from cardiovascular events. This study aimed to explore the effects of statin treatment on serum lipidomic profile and to identify biomarkers of response in subjects with FH. Seventeen adult FH patients underwent a 6-week washout followed by 4-week treatment with atorvastatin (80 mg/day) or rosuvastatin (40 mg/day). LDL-c response was considered good (40-70 % reduction, n = 9) or poor (3-33 % reduction, n = 8). Serum lipidomic profile was analyzed by ultra-high-performance liquid chromatography combined with electrospray ionization tandem time-of-flight mass spectrometry, and data were analyzed using MetaboAnalyst v5.0. Lipidomic analysis identified 353 lipids grouped into 16 classes. Statin treatment reduced drastically 8 of 13 lipid classes, generating a characteristic lipidomic profile with a significant contribution of phosphatidylinositols (PI) 16:0/18:2, 18:0/18:1 and 18:0/18:2, and triacylglycerols (TAG) 18:2x2/18:3, 18:1/18:2/18:3, 16:1/18:2x2, 16:1/18:2/18:3 and 16:1/18:2/Arachidonic acid (p-adjusted <0.05). Biomarker analysis implemented in MetaboAnalyst subsequently identified PI 16:1/18:0, 16:0/18:2 and 18:0/18:2 as predictors of statin response with and receiver operating characteristic (ROC) areas under the curve of 0.98, 0.94 and 0.91, respectively. In conclusion, statins extensively modulate the overall serum lipid composition of FH individuals and these findings suggest that phosphatidyl-inositol molecules are potential predictive biomarkers of statin response.
Fecha Publicación	2023
Tipo de Recurso	artículo original
doi	10.1016/j.chemphyslip.2023.105348
Formato Recurso	PDF
Palabras Claves	Familial hypercholesterolemia Lipid-lowering drugs Statin Lipidomics Phosphatidyl-inositol Biomarkers
Ubicación del archivo	http://dx.doi.org/10.1016/j.chemphyslip.2023.105348
Categoría OCDE	Bioquímica y biología molecular Biofísica
Materias	Hipercolesterolemia familiar Medicamentos hipolipemiantes Estatina Lipidómica Fosfatidil-inositol Biomarcadores
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	versión publicada
Derechos de acceso	metadata
Access Rights	metadata
Id de Web of Science	WOS:001099908900001
ISSN	0009-3084
Tipo de ruta	hibrida
Categoría WOS	Bioquímica y biología molecular Biofísica
Referencia del Financiador (Mandatado si es aplicable-repetible)	FAPESP 13/07937-8