Lipidomic analysis identified potential predictive biomarkers of statin response in subjects with Familial hypercholesterolemia
| Primer Autor |
Hirata, Mario Hiroyuki
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| Co-autores |
Cerda, Alvaro
Bortolin, Raul Hernandes
Yoshinaga, Marcos Yukio
de Freitas, Renata Caroline Costa
Dagli-Hernandez, Carolina
Borges, Jessica Bassani
de Oliveira, Victor Fernandes
Goncalves, Rodrigo Marques
Faludi, Andre Arpad
Bastos, Gisele Medeiros
Hirata, Rosario Dominguez Crespo
|
| Título |
Lipidomic analysis identified potential predictive biomarkers of statin response in subjects with Familial hypercholesterolemia
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| Editorial |
ELSEVIER IRELAND LTD
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| Revista |
CHEMISTRY AND PHYSICS OF LIPIDS
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| Lenguaje |
en
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| Resumen |
Familial hypercholesterolemia (FH) is a disorder of lipid metabolism that causes elevated low-density lipoprotein cholesterol (LDL-c) and increased premature atherosclerosis risk. Statins inhibit endogenous cholesterol biosynthesis, which reduces LDL-c plasma levels and prevent from cardiovascular events. This study aimed to explore the effects of statin treatment on serum lipidomic profile and to identify biomarkers of response in subjects with FH. Seventeen adult FH patients underwent a 6-week washout followed by 4-week treatment with atorvastatin (80 mg/day) or rosuvastatin (40 mg/day). LDL-c response was considered good (40-70 % reduction, n = 9) or poor (3-33 % reduction, n = 8). Serum lipidomic profile was analyzed by ultra-high-performance liquid chromatography combined with electrospray ionization tandem time-of-flight mass spectrometry, and data were analyzed using MetaboAnalyst v5.0. Lipidomic analysis identified 353 lipids grouped into 16 classes. Statin treatment reduced drastically 8 of 13 lipid classes, generating a characteristic lipidomic profile with a significant contribution of phosphatidylinositols (PI) 16:0/18:2, 18:0/18:1 and 18:0/18:2, and triacylglycerols (TAG) 18:2x2/18:3, 18:1/18:2/18:3, 16:1/18:2x2, 16:1/18:2/18:3 and 16:1/18:2/Arachidonic acid (p-adjusted <0.05). Biomarker analysis implemented in MetaboAnalyst subsequently identified PI 16:1/18:0, 16:0/18:2 and 18:0/18:2 as predictors of statin response with and receiver operating characteristic (ROC) areas under the curve of 0.98, 0.94 and 0.91, respectively. In conclusion, statins extensively modulate the overall serum lipid composition of FH individuals and these findings suggest that phosphatidyl-inositol molecules are potential predictive biomarkers of statin response.
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| Fecha Publicación |
2023
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| Tipo de Recurso |
artículo original
|
| doi |
10.1016/j.chemphyslip.2023.105348
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| Formato Recurso |
PDF
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| Palabras Claves |
Familial hypercholesterolemia
Lipid-lowering drugs
Statin
Lipidomics
Phosphatidyl-inositol
Biomarkers
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| Ubicación del archivo | |
| Categoría OCDE |
Bioquímica y biología molecular
Biofísica
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| Materias |
Hipercolesterolemia familiar
Medicamentos hipolipemiantes
Estatina
Lipidómica
Fosfatidil-inositol
Biomarcadores
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| Identificador del recurso (Mandatado-único) |
artículo original
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| Versión del recurso (Recomendado-único) |
versión publicada
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| Derechos de acceso |
metadata
|
| Access Rights |
metadata
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| Id de Web of Science |
WOS:001099908900001
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| ISSN |
0009-3084
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| Tipo de ruta |
hibrida
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| Categoría WOS |
Bioquímica y biología molecular
Biofísica
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
FAPESP 13/07937-8
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