Repositorio
Institucional

Sandoval, Cristian

Nahuelqueo, Karen

Mella, Luciana

Recabarren, Blanca

Souza-Mello, Vanessa

Farias, Jorge

Role of long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic, in the regulation of gene expression during the development of obesity: a systematic review

FRONTIERS MEDIA SA

FRONTIERS IN NUTRITION

en

Introduction: There exists a correlation between obesity and the consumption of an excessive amount of calories, with a particular association between the intake of saturated and trans fats and an elevated body mass index. Omega-3 fatty acids, specifically eicosapentaenoic and docosahexaenoic acids, have been identified as potential preventive nutrients against the cardiometabolic hazards that are commonly associated with obesity. The objective of this comprehensive review was to elucidate the involvement of long-chain polyunsaturated fatty acids, specifically eicosapentaenoic acid and docosahexaenoic acid, in the modulation of gene expression during the progression of obesity. Methods: The present analysis focused on primary studies that investigated the association between long-chain polyunsaturated fatty acids, gene expression, and obesity in individuals aged 18 to 65 years. Furthermore, a comprehensive search was conducted on many databases until August 2023 to identify English-language scholarly articles utilizing MeSH terms and textual content pertaining to long-chain polyunsaturated fatty acids, gene expression, obesity, and omega-3. The protocol has been registered on PROSPERO under the registration number CRD42022298395. A comprehensive analysis was conducted on a total of nine primary research articles. All research collected and presented quantitative data. Results and Discussion: The findings of our study indicate that the incorporation of eicosapentaenoic and docosahexaenoic acid may have potential advantages and efficacy in addressing noncommunicable diseases, including obesity. This can be attributed to their anti-inflammatory properties and their ability to regulate genes associated with obesity, such as PPAR gamma and those within the ALOX family.

2023

artículo de revisión

10.3389/fnut.2023.1288804

PDF

gene expression

nutrigenomics

omega-3

epigenetics

molecular biology

Nutrición y Dietética

expresion genica

nutrigenómica

Omega 3

epigenética

Biología Molecular

artículo de revisión

versión publicada

CC BY 4.0

CC BY 4.0

acceso abierto

acceso abierto

WOS:001106862600001

2296-861X

verde# dorado

Nutrición y Dietética

ANID CCSS210005

UFRO PDT22- 0001

UFRO DI22-0007