Role of long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic, in the regulation of gene expression during the development of obesity: a systematic review
| Primer Autor |
Sandoval, Cristian
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| Co-autores |
Nahuelqueo, Karen
Mella, Luciana
Recabarren, Blanca
Souza-Mello, Vanessa
Farias, Jorge
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| Título |
Role of long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic, in the regulation of gene expression during the development of obesity: a systematic review
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| Editorial |
FRONTIERS MEDIA SA
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| Revista |
FRONTIERS IN NUTRITION
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| Lenguaje |
en
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| Resumen |
Introduction: There exists a correlation between obesity and the consumption of an excessive amount of calories, with a particular association between the intake of saturated and trans fats and an elevated body mass index. Omega-3 fatty acids, specifically eicosapentaenoic and docosahexaenoic acids, have been identified as potential preventive nutrients against the cardiometabolic hazards that are commonly associated with obesity. The objective of this comprehensive review was to elucidate the involvement of long-chain polyunsaturated fatty acids, specifically eicosapentaenoic acid and docosahexaenoic acid, in the modulation of gene expression during the progression of obesity. Methods: The present analysis focused on primary studies that investigated the association between long-chain polyunsaturated fatty acids, gene expression, and obesity in individuals aged 18 to 65 years. Furthermore, a comprehensive search was conducted on many databases until August 2023 to identify English-language scholarly articles utilizing MeSH terms and textual content pertaining to long-chain polyunsaturated fatty acids, gene expression, obesity, and omega-3. The protocol has been registered on PROSPERO under the registration number CRD42022298395. A comprehensive analysis was conducted on a total of nine primary research articles. All research collected and presented quantitative data. Results and Discussion: The findings of our study indicate that the incorporation of eicosapentaenoic and docosahexaenoic acid may have potential advantages and efficacy in addressing noncommunicable diseases, including obesity. This can be attributed to their anti-inflammatory properties and their ability to regulate genes associated with obesity, such as PPAR gamma and those within the ALOX family.
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| Fecha Publicación |
2023
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| Tipo de Recurso |
artículo de revisión
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| doi |
10.3389/fnut.2023.1288804
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| Formato Recurso |
PDF
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| Palabras Claves |
gene expression
nutrigenomics
omega-3
epigenetics
molecular biology
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| Ubicación del archivo | |
| Categoría OCDE |
Nutrición y Dietética
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| Materias |
expresion genica
nutrigenómica
Omega 3
epigenética
Biología Molecular
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| Identificador del recurso (Mandatado-único) |
artículo de revisión
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| Versión del recurso (Recomendado-único) |
versión publicada
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| License |
CC BY 4.0
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| Condición de la licencia (Recomendado-repetible) |
CC BY 4.0
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| Derechos de acceso |
acceso abierto
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| Access Rights |
acceso abierto
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| Id de Web of Science |
WOS:001106862600001
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| ISSN |
2296-861X
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| Tipo de ruta |
verde# dorado
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| Categoría WOS |
Nutrición y Dietética
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| Referencia del Financiador (Mandatado si es aplicable-repetible) |
ANID CCSS210005
UFRO PDT22- 0001
UFRO DI22-0007
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