miR-6805-5p as a biomarker of cisplatin-induced nephrotoxicity in patients with head and neck cancer

Primer Autor
Moriel, Patricia
Co-autores
Torso, Nadine De Godoy
Quintanilha, Julia Coelho Franca
Cursino, Maria Aparecida
Pincinato, Eder De Carvalho
Loren, Pia
Salazar, Luis A.
Lima, Carmen Silvia Passos
Título
miR-6805-5p as a biomarker of cisplatin-induced nephrotoxicity in patients with head and neck cancer
Editorial
FRONTIERS MEDIA SA
Revista
FRONTIERS IN PHARMACOLOGY
Lenguaje
en
Resumen
Introduction: The standard treatment for head and neck squamous cell carcinoma (HNSCC) is cisplatin chemoradiotherapy. One of the main treatment adverse reactions is nephrotoxicity, for which there is currently no adequate specific and sensitive biomarker. Thus, this study aimed to evaluate the use of microRNAs (miRNAs) as renal biomarker candidates.Methods: This was a retrospective cohort study. Nephrotoxicity was assessed through blood samples collected before and 5 days (D5) after chemotherapy. MiRNAs were extracted from urine samples collected at baseline and D5, and RNA sequencing identified miRNAs differentially expressed between participants with and without cisplatin-induced nephrotoxicity.Results: A total of 49 participants were included (n = 49). A significant difference was seen between the two groups for traditional renal markers (serum creatinine and creatinine clearance) and for the acute kidney injury (AKI) categories. Among the six miRNAs evaluated as biomarkers, four were upregulated (hsa-miR-6729-5p, hsa-miR-1238-5p, hsa-miR-4706, and hsa-miR-4322) and two were downregulated (hsa-miR-6805-5p and hsa-miR-21-5p), but only hsa-miR-6805-5p had a significant difference (p < 0.0001). Its receiver operating characteristic curve revealed excellent specificity (0.920) for its expression fluctuation assessment, while its absolute expression in D5 showed greater sensitivity (0.792).Conclusion: So, the integrated use of these two parameters seems to be an interesting approach for AKI.
Fecha Publicación
2023
Tipo de Recurso
artículo original
doi
10.3389/fphar.2023.1275238
Formato Recurso
PDF
Palabras Claves
cisplatin
nephrotoxicity
acute kidney injury
biomarker
microRNA
miRNA
Ubicación del archivo
http://dx.doi.org/10.3389/fphar.2023.1275238
Categoría OCDE
Farmacología y farmacia
Materias
cisplatino
nefrotoxicidad
Lesión renal aguda
biomarcador
microARN
miARN
Identificador del recurso (Mandatado-único)
artículo original
Versión del recurso (Recomendado-único)
versión publicada
License
CC BY 4.0
Condición de la licencia (Recomendado-repetible)
CC BY 4.0
Derechos de acceso
acceso abierto
Access Rights
acceso abierto
Id de Web of Science
WOS:001122682900001
Tipo de ruta
verde# dorado
Categoría WOS
Farmacología y farmacia
Referencia del Financiador (Mandatado si es aplicable-repetible)
FAPESP 10.13039/501100001807
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Colección ANID
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