Repositorio UFRO · Omeka S

miR-6805-5p as a biomarker of cisplatin-induced nephrotoxicity in patients with head and neck cancer

Primer Autor	Moriel, Patricia
Co-autores	Torso, Nadine De Godoy Quintanilha, Julia Coelho Franca Cursino, Maria Aparecida Pincinato, Eder De Carvalho Loren, Pia Salazar, Luis A. Lima, Carmen Silvia Passos
Título	miR-6805-5p as a biomarker of cisplatin-induced nephrotoxicity in patients with head and neck cancer
Editorial	FRONTIERS MEDIA SA
Revista	FRONTIERS IN PHARMACOLOGY
Lenguaje	en
Resumen	Introduction: The standard treatment for head and neck squamous cell carcinoma (HNSCC) is cisplatin chemoradiotherapy. One of the main treatment adverse reactions is nephrotoxicity, for which there is currently no adequate specific and sensitive biomarker. Thus, this study aimed to evaluate the use of microRNAs (miRNAs) as renal biomarker candidates.Methods: This was a retrospective cohort study. Nephrotoxicity was assessed through blood samples collected before and 5 days (D5) after chemotherapy. MiRNAs were extracted from urine samples collected at baseline and D5, and RNA sequencing identified miRNAs differentially expressed between participants with and without cisplatin-induced nephrotoxicity.Results: A total of 49 participants were included (n = 49). A significant difference was seen between the two groups for traditional renal markers (serum creatinine and creatinine clearance) and for the acute kidney injury (AKI) categories. Among the six miRNAs evaluated as biomarkers, four were upregulated (hsa-miR-6729-5p, hsa-miR-1238-5p, hsa-miR-4706, and hsa-miR-4322) and two were downregulated (hsa-miR-6805-5p and hsa-miR-21-5p), but only hsa-miR-6805-5p had a significant difference (p < 0.0001). Its receiver operating characteristic curve revealed excellent specificity (0.920) for its expression fluctuation assessment, while its absolute expression in D5 showed greater sensitivity (0.792).Conclusion: So, the integrated use of these two parameters seems to be an interesting approach for AKI.
Fecha Publicación	2023
Tipo de Recurso	artículo original
doi	10.3389/fphar.2023.1275238
Formato Recurso	PDF
Palabras Claves	cisplatin nephrotoxicity acute kidney injury biomarker microRNA miRNA
Ubicación del archivo	http://dx.doi.org/10.3389/fphar.2023.1275238
Categoría OCDE	Farmacología y farmacia
Materias	cisplatino nefrotoxicidad Lesión renal aguda biomarcador microARN miARN
Identificador del recurso (Mandatado-único)	artículo original
Versión del recurso (Recomendado-único)	versión publicada
License	CC BY 4.0
Condición de la licencia (Recomendado-repetible)	CC BY 4.0
Derechos de acceso	acceso abierto
Access Rights	acceso abierto
Id de Web of Science	WOS:001122682900001
Tipo de ruta	verde# dorado
Categoría WOS	Farmacología y farmacia
Referencia del Financiador (Mandatado si es aplicable-repetible)	FAPESP 10.13039/501100001807